[1]张宁,艾斯卡尔,胡晓刚,等.非肌层浸润性膀胱癌2种术式的比较[J].中国微创外科杂志,2017,17(07):599-601.
　Zhang Ning,Aisikaer,Hu Xiaogang,et al.A Comparative Study on the Treatment of Non-muscle Invasive Bladder Cancer by Two Transurethral Resections of Bladder Tumor[J].Chinese Journal of Minimally Invasive Surgery,2017,17(07):599-601.
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非肌层浸润性膀胱癌2种术式的比较()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
17
期数:
2017年07期
页码:
599-601
栏目:
临床论著
出版日期:
2017-07-20

文章信息/Info

Title:
A Comparative Study on the Treatment of Non-muscle Invasive Bladder Cancer by Two Transurethral Resections of Bladder Tumor
作者:
张宁; 艾斯卡尔; 胡晓刚; 李雪青; 巴特巴依尔; 陈文新**
新疆自治区人民医院北院泌尿外科，乌鲁木齐830054
Author(s):
Zhang Ning;  Aisikaer;  Hu Xiaogang;  et al.
Department of Urology, The North Hospital of People’s Hospital of Xinjiang Uigur Autonomous Region, Urumqi 830054,China
关键词:
非肌层浸润性膀胱癌; 钬激光; 经尿道膀胱肿瘤电切术
Keywords:
Non-muscle invasive bladder cancer; Holmium laser; Transurethral resection of bladder tumor
文献标志码:
A
摘要:
目的探讨非肌层浸润性膀胱癌2种术式的安全性和有效性。方法2008年1月~2015年12月100例非肌层浸润性膀胱癌随机分为经尿道钬激光切除术组（HoLRBT组）和经尿道等离子电切术（TURBT组），每组50例，因失访、临床分期和分级变化更改治疗方案、不耐受手术、术后治疗等原因，最终75例进入本研究，其中HoLRBT组37例， TURBT组38例，比较2组手术时间、并发症发生率、术后住院时间及肿瘤复发情况。结果HOLRBT、TURBT组手术时间中位数分别为18 min(10~50 min)和20 min（15~45 min），无统计学差异（Z=-1.557,P=0.119）;膀胱穿孔发生率［0 vs.10.5%(4/38)，Fisher精确检验，P=0.115］、术后低钠血症发生率［0.3%(1/37) vs.18.4%(7/38)， χ2=3.351，P=0.067］、术后住院时间［(3.2±0.6) d vs.(3.1±0.5) d，t=0.785，P=0.435］、术后复发率［5.4%(2/37) vs.7.9%(3/38)， χ2=0.000，P=1.000］均无统计学差异。与TURBT组相比，HoLRBT组闭孔神经反射发生率明显降低［0 vs. 26.3%(10/38)，Fisher精确检验，P=0001］。结论与传统TURBT相比，HoLRBT治疗非肌层浸润性膀胱癌安全、有效，并发症少，值得临床推广。
Abstract:
ObjectiveTo discuss the safety and efficacy of two transurethral resections of bladder tumor in the treatment of non-muscle invasive bladder cancer.Methods A total of 75 patients with non-muscle invasive bladder cancer in our hospital between January 2008 to December 2015 were randomly divided into two groups, transurethral holmium laser resection of bladder tumor group (HoLRBT group, n=37) or transurethral resection of bladder resection (TURBT) group (TURBT group, n=38). The operation time, complication rate, postoperative hospital stay, and tumor recurrence were compared between two groups. ResultsThere was no statistical difference in median operative time ［18 min (10-50 min) min vs. 20 min (15-45) min, Z=-1.557,P=0.119］, bladder perforation ［0 vs. 10.5%(4/38), Fisher’s exact test, P=0.115］, postoperative hyponatremia ［03% (1/37) vs. 18.4% (7/38), χ2=3.351, P=0067］, postoperative hospital stay ［(3.2±0.6) d vs. (3.1±0.5) d, t=0.785, P=0.435］, recurrence rate ［5.4% (2/37) vs. 7.9% (3/38), χ2=0.000, P=1.000］ between the two groups. As compared to TURBT group, there was less obturator nerve reflex (0 vs. 26.3% (10/38), Fisher’s exact test,P=0.001) in HoLRBT group.ConclusionCompared with curative TURBT, HoLRBT has the characteristics of safety, effectiveness and fewer complications in the treatment of non-muscle invasive bladder cancer, warranting an extensive use clinically.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：新疆自治区人民医院院内项目（20120133）**通讯作者，E-mail：879874697@qq.com
更新日期/Last Update: 2017-09-21