[1]刘宝胤,骆成玉,张键,等.乳腺密度与乳腺癌保乳手术后复发风险的关系[J].中国微创外科杂志,2010,10(12):1060-1065.
　Liu Baoyin,Luo Chengyu,Zhang Jian,et al.Relationship between Breast Density and Breast Cancer Recurrence after BreastConserving Surgery[J].Chinese Journal of Minimally Invasive Surgery,2010,10(12):1060-1065.
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乳腺密度与乳腺癌保乳手术后复发风险的关系()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
10
期数:
2010年12期
页码:
1060-1065
栏目:
出版日期:
2010-12-31

文章信息/Info

Title:
Relationship between Breast Density and Breast Cancer Recurrence after BreastConserving Surgery
作者:
刘宝胤; 骆成玉; 张键; 季晓昕
首都医科大学附属复兴医院普外科，北京100038
Author(s):
Liu Baoyin;  Luo Chengyu;  Zhang Jian;  et al.
Department of General Surgery, Fuxing Hospital, Capital Medical University, Beijing 100038, China
关键词:
乳腺密度; 乳腺癌; 局部复发; 保乳手术
Keywords:
Breast density; Breast cancer; Local recurrence; Breastconserving surgery
分类号:
R737.9
文献标志码:
A
摘要:
目的探讨乳腺X密度等级与乳腺癌保乳术后复发风险的关系。方法2002年1月~2005年7月，180例接受保乳手术的乳腺癌在术后5~8年（平均61年）进行随访，对术前X线乳腺钼靶像按照BI-RADS标准，以乳腺百分密度分为<25%、25%~50%、51%~75%、>75% 4个等级，以包含乳腺密度在内的11个相关因素做单因素分析筛选出有意义的影响因素再进行logistic回归多因素分析，评价乳腺密度与乳癌保乳术后复发的关系。结果logistic回归多因素分析显示术后放疗和乳腺密度是术后复发的影响因素（Wald χ2=9.429,P=0.002;Wald χ2=9.346,P=0.002）;4个密度组的复发率依次为6.2%（3/48）、12.0%（6/50）、11.6%(5/43)、28.2%(11/39)，乳腺密度越高，局部复发风险越大。乳腺密度不是术后转移的影响因素（Wald χ2=2.944,P=0.400），各密度组间远处转移率依次为16.7%(8/48)、14.0%(7/50)、70%(3/43)、77%(3/39)，远处转移风险不随乳腺密度增高而加大。术后化疗和腋窝淋巴结转移是术后转移的影响因素（Wald χ2=4334,P=0.037;Wald χ2=4.417，P=0.036）。结论乳腺密度与乳腺癌保乳术后复发有相关性，但不是术后远处转移的危险因素。
Abstract:
ObjectiveTo study the relationship between the qualitative classification of breast density on mammography and the risk of breast cancer recurrence after breastconserving surgery. MethodsTotally 180 patients, who underwent breastconserving surgery for breast cancer from January 2002 to July 2005, were reviewed and followed for 5 to 8 years (mean, 6.1 years). According to the of breast density (in percentage) on mammography, the patients were divided into 4 groups: <25%, 25%-50%, 50%-75%, and >75% groups based on the BIRADS classification. Afterwards, 11 factors including breast density were analyzed by one way ANOVA, and then logistic regression was employed on significant factors.ResultsLogistic regression showed that postoperative radiotherapy and breast density are the influencing factors of recurrent breast cancer (Wald χ2=9.429, P=0.002; Wald χ2=9.346, P=0.002). The recurrence rate in the <25%, 25%-50%, 50%-75%, and >75% groups was 6.2% (3/48), 12.0% (6/50), 11.6% (5/43), and 28.2% (11/39), respectively, which suggested that the recurrence rate increased with breast density. Whereas, postoperative chemotherapy and metastasis to the axillary lymph nodes, but not breast density, were the influence factors of postoperative metastasis (Wald χ2=2.944, P=0.400); the metastasis rate in the four groups was 16.7% (8/48), 14.0% (7/50), 7.0% (3/43), and 7.7% (3/39) respectively, showing no increasing trend with breast density (Wald χ2=4.334, P=0037; Wald χ2=4.417, P=0.036). ConclusionBreast density on mammography is related with breast cancer recurrence after breastconserving surgery, but is not the risk factor of distant metastasis.

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更新日期/Last Update: 2013-08-12