[1]李欣,修典荣＊,王俊杰①,等.放射介入、姑息手术以及姑息手术联合125Ⅰ粒子植入治疗晚期胰腺癌临床疗效比较[J].中国微创外科杂志,2006,06(4):287-289.
　LiXin*,Xiu Dianrong*,Wang Junjie,et al.Comparisons of curative effects from interventional therapy, palliative operation, and palliative operation combined with 125I seed implantation for advanced pancreatic carcinoma[J].Chinese Journal of Minimally Invasive Surgery,2006,06(4):287-289.
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放射介入、姑息手术以及姑息手术联合125Ⅰ粒子植入治疗晚期胰腺癌临床疗效比较()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
06
期数:
2006年4期
页码:
287-289
栏目:
出版日期:
2006-04-20

文章信息/Info

Title:
Comparisons of curative effects from interventional therapy, palliative operation, and palliative operation combined with 125I seed implantation for advanced pancreatic carcinoma
作者:
李欣; 修典荣＊; 王俊杰①; 冉维强②
北京大学第三医院普通外科,北京,100083
Author(s):
LiXin*;  Xiu Dianrong*;  Wang Junjie;  et al.*
Departmentof General Surgery, Peking University Third Hospital, Beijing 100083, China
关键词:
晚期胰腺癌; 姑息性手术; 125Ⅰ粒子植入
Keywords:
Advanced pancreatic carcinoma; 　Palliative operation; 　125I seed implantation
分类号:
R735.9
文献标志码:
A
摘要:
目的探讨放射介入、姑息手术以及姑息手术联合125Ⅰ粒子植入3种方法治疗晚期胰腺癌的疗效.方法1994年3月～2005年10月,我院对103例无法切除的胰腺癌分别行放射介入(经肝穿刺置管内引流组,15例),胆肠、胃肠吻合术(姑息手术组,60例)及姑息手术同时行超声引导下125Ⅰ粒子植入治疗(姑息手术联合125Ⅰ粒子植入组,28例).结果姑息手术联合125Ⅰ粒子植入组术前的疼痛的21例术后疼痛部分缓解率及完全缓解率分别为14.3%(3/21)及76.2%(16/21),显著高于其他2组(x2=6.305,P=0.012;x2=4.525,P=0.033).姑息手术联合125Ⅰ粒子植入组的中位生存时间(8个月)显著长于姑息手术组(7个月)及经肝穿刺置管内引流组(2个月)(P=0.0005).结论对于不能耐受手术的晚期胰腺癌可行经肝穿刺置管内引流治疗,姑息手术联合125Ⅰ粒子植入治疗在延长生存期的同时可明显缓解患者的疼痛.
Abstract:
Objective　To investigate curative effects of interventional therapy, palliative operation, and palliative operation combined with125I seed implantation for the treatment of advanced pancreatic carcinoma.　M ethods　A total of 103 patients with unresectable pancreatic cancerwere treated with percutaneous transhepatic cholangiography and drainage ( InterventionalGroup, 15 patients), or cholangiojejunostomy and gastroenterostomy (Palliative Group, 60 patients), or palliative operation combined with ultrasound-guided125I seed interstitial implantation (Combination Group, 28 patients), respectively.　Results　Of 21 patientswith preoperative pain in the Combination Group, the rate of partial pain relief and complete pain reliefwere 14. 3% (3/21) and 76. 2% (16/21), respectively, whichwere significantly higher than those in the other two groups (χ2=6.305, P=0.012;χ2=4.525, P= 0. 033). Themedian survival time was significantly longer in the Combination Group (8 months) than in the Palliative Group (7 months) and the InterventionalGroup (2 months) (P=0. 0005).　Conclusions　Percutaneous transhepatic cholangiography and drainage can be applied to patients who cannot tolerate open surgery. Conventional palliative operations combined with125I seed implantation benefits the patients both in survival time and in pain relie.

参考文献/References:

[1]倪泉兴,张群华,傅德良,等.胰头癌治愈性切除水平30年的变化.中华肝胆外科杂志,2000,6(2):92-94.
[2]葛辉玉,冉维强,苗立英,等.术中超声引导下125Ⅰ粒子植入放射治疗胰腺癌17例临床观察.中国微创外科杂志,2005,5(7):542-544.
[3]王雪峰,顾钧,沈定丰,等.金属内支架置入治疗胃十二指肠恶性梗阻.中国微创外科杂志,2005,5(7):532-533.
[4]党彤,钱峰,陈言东,等.经内镜内外引流治疗不同部位胆道梗阻方法探讨(附104例报告).中国微创外科杂志,2004,4(3):201-203.
[5]罗开元,毛文源,李波,等.125Ⅰ粒子组织间永久植入治疗恶性肿瘤的疗效观察.中华外科杂志,2003,41(2):122-124.
[6]Shapiro AM,Bain UG,Sigalet DL,et al.Rapid resolution of chylous ascites after liver transplantation using somatostatin analog and parenteral nutrition.Transplantation,1996,61:1410-1411.
[7]Senyuz OF,Senturk H,Tasci H,et al.Chylous ascites after liver transplantation with mesentero-portal jump graft.J Hepatobiliary Pancreat Surg,2001,8:571-572.
[8]Peretz,T,Nori D,Hilaris B,et al.Treatment of primary carcinoma of the pancreas with Ⅰ-125 implantation.Int J Radiat Oncol Biol Phys,1989,17(5):931 -935.

备注/Memo

备注/Memo:
＊通讯作者，①肿瘤放疗科，②超声诊断科
更新日期/Last Update: 2014-01-27