[1]何文,梁晓宁,张晓蓉,等.超声引导微波联合肝动脉化疗栓塞术治疗大肝癌的疗效评价[J].中国微创外科杂志,2005,05(1):31-33.
　He Wen*,Liang Xiaoning,Zhang Xiaorong*,et al.Evaluation of ultrasound-guided microwave coagulation in combination with transarterial chemoembolization for large hepatic cancers[J].Chinese Journal of Minimally Invasive Surgery,2005,05(1):31-33.
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超声引导微波联合肝动脉化疗栓塞术治疗大肝癌的疗效评价()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年1期
页码:
31-33
栏目:
出版日期:
2005-01-30

文章信息/Info

Title:
Evaluation of ultrasound-guided microwave coagulation in combination with transarterial chemoembolization for large hepatic cancers
作者:
何文; 梁晓宁; 张晓蓉; 姜晓红; 郑永才; 张颖
首都医科大学附属北京天坛医院超声科,北京,100050
Author(s):
He Wen*;  Liang Xiaoning;  Zhang Xiaorong*;  et al.
*Department of Ultrasonography, Beijing Tiantan Hospital of Capital University of Medical Sciences, Beijing 100050, China
关键词:
大肝癌;  微波;  肝动脉化疗栓塞术;  超声
Keywords:
Large hepatic cancer; 　Microwave; 　Transarterial chemoembolization
分类号:
R735.7
文献标志码:
A
摘要:
目的探讨超声引导微波联合肝动脉化疗栓塞术(transarterial chemoembolization,TACE)治疗大肝癌的疗效.方法 35例大肝癌采用超声引导微波联合TACE介入治疗(微波联合TACE组),并选择同期40例大肝癌采用单纯微波治疗(单纯微波治疗组)和31例采用单纯TACE治疗(单纯TACE治疗组)作为对照. 结果微波联合TACE治疗后30例AFP降至正常,3例明显下降;超声检查:80.0%(28/35)肿块缩小 ,20.0%(7/35)无变化, 肿块中心回声增强 , 周边呈低回声, 境界清晰, 其中可见钙化回声, 肿瘤内血流消失或减少.12例超声引导下活检,病理组织学结果显示: 肿瘤完全坏死9例,不完全坏死3例.30例CT检查, 76.7%(23/30)肿块缩小.微波联合TACE组缓解率(CR+PR)88.6%(31/35),1、2、3、5年生存率分别为88.6%(31/35)、71.4%(25/35)、60.0%(21/35)、42.9%(15/35),均高于单纯微波组及单纯TACE组.无严重并发症发生. 结论超声引导微波联合TACE介入治疗大肝癌安全、有效、实用, 比单纯微波或TACE治疗效果好,为不能手术切除或其它治疗效果不佳的大肝癌提供了一种可行和有效的治疗方法.
Abstract:
Objective　To discuss the effectiveness of ultrasound- guided microwave coagulation combined with transarterial chemoembolization (TACE) in the management of large hepatic cancers.　Methods　Atotal of 35 patientswith large hepatic cancer received ultrasound-guided microwave coagulation combined with TACE (Combination Group), while, served as control groups, 40 patients with the same diagnosis from the same period underwent only ultrasound-guided microwave coagulation (Microwave Group) and 31 patients underwent only TACE (TACE Group).　Results　In the Combination Group the serum AFP level dropped to normal limits in 30 patients and decreased obviously in 3 patients. Ultrasonography showed that lesions had decreased in size in 80.0% of the patients (28/35) and had not changed in 20.0% of the patients (7/35). Hyperechoic status was found in the central part of the lesions, and the outer part of the lesions was hypoechoic, with clear border. Calcification echo, with disappeared or decreased blood flow signals, was detected inside the lesions. Pathological examinations from ultrasound-guided biopsy in 12 patients revealed complete necrosis of lesions in 9 patients and partial necrosis in 3 patients. CT scans in 30 patients showed lesions decreased in size in 76.7% of the patients (23/30) .In the Combination Group, the remission rate (CR+PR) was 88·6% (31/35), and the 1-, 2-, 3-, and 5-year survival rates were 88·6% (31/35), 71·4% (25/ 35), 60·0% (21/35), and 42·9% (15/35), respectively, all of which were higher than those in the Microwave Group or in the TACE Group. In the study no severe complications occurred.　Conclusions　Combination application of ultrasound-guided microwave coagulation and TACE is safe, effective and practical, superiortomicrowave therapy orTACE. It is an effective and practicalway for large hepatic cancers inoperable or unresponsive to other measures.

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备注/Memo

备注/Memo:
①（北京朝阳医院超声科,北京,100020）,②（北京朝阳小庄医院超声科,北京,100020）
更新日期/Last Update: 2014-03-11