[1]刘原照　 范虹　 褚德发.X线立体定向治疗脑转移瘤疗效分析[J].中国微创外科杂志,2003,03(2):143-144.
　Liu Yuanzhao,FanHong,ChuDefa..Stereotactic radiotherapy in the treatment of brain metastases[J].Chinese Journal of Minimally Invasive Surgery,2003,03(2):143-144.
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X线立体定向治疗脑转移瘤疗效分析()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
03
期数:
2003年2期
页码:
143-144
栏目:
出版日期:
2003-02-28

文章信息/Info

Title:
Stereotactic radiotherapy in the treatment of brain metastases
作者:
刘原照　 范虹　 褚德发
北京医院放疗科,北京,100730
Author(s):
Liu Yuanzhao;  FanHong;  ChuDefa.
Department ofRadiotherapy, Bei- jingHospital, Beijing100730, China
关键词:
脑转移瘤 立体定向治疗
Keywords:
Brain metastasis　Stereotactic radiotherapy
分类号:
R739.41
文献标志码:
A
摘要:
目的探讨影响X线立体定向治疗(Stereotactic radiotherapy,SRT)脑转移瘤疗效及并发症的相关因素. 方法对77例(156个脑转移灶)进行回顾性分析.142个脑转移灶采用X线立体定向治疗联合常规全脑放疗,14个脑转移灶单纯采用X线立体定向治疗. 结果多因素分析脑转移瘤X线立体定向治疗有效率和并发症率与转移灶体积及周边剂量有关.转移灶体积≤4ml的有效率为81.0%(85/105),明显高于转移灶体积＞4ml有效率的45.1%(23/51)(χ2=20.7,P＜0.001),并发症率由3.8%(4/105)上升至29.4%(15/51)(χ2=21,P＜0.001).靶周剂量(ED2Gy)＞68Gy的有效率为81.3%(65/80),显著高于ED2Gy≤68Gy的56.6%(43/76)(χ2=11.1,P＜0.001),并发症率由18.8%(15/80)下降至5.3%(4/76)(χ2=6.6,P＜0.05). 结论脑转移瘤体积及靶周剂量是影响SRT疗效和并发症的两个最重要因素.
Abstract:
Objective　To evaluate correlative factors of efficacy and complications of stereotactic radiosurgery for brain metastases.　 Methods　A total of 77 cases, involving 156 brain metastases, were analyzed retrospectively. Out of the 156 lesions, 142 metastatic brain tu- mors were dealt with by stereotactic radiotherapy combined with whole-brain irradiation and 14 metastatic brain tumors by stereotactic radio- therapy alone.　Results　Multiple factor analyses suggested that the effective rate and complication rate of stereotactic radiotherapy for brain metastaseswere correlative to tumor volumes and radiation doses. The effective rate of group with tumor volume≤4 ml was 81.0% (85 of 105), markedly higher than that of group>4 ml, which was 45·1% (23 of 51)(χ2=20·7, P<0·001). And the rates of complication of group≤4 ml and group>4 mlwere 3·8% (4 of 105) and 29·4% (15 of 51) respectively, with statistically significant difference between the two groups (χ2=21, P<0·001). The effective rate of group with radiation dose (ED2Gy)>68Gy was 81·3% (65 of 80), and group≤ 68Gy 56·6% (43 of 76)(χ2=11·1, P<0·001), while the rate of complication of the former group was 5·3% (4 of 76) and the latter 18·8% (15 of 80)(χ2=6·6, P<0·05).　Conclusions　Tumor volume and radiation dose are closely correlated with curative effect and complications of stereotactic radiotherapy.

参考文献/References:

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更新日期/Last Update: 2014-06-10