[1]赵海涛　 芮静安　 赵屹①　 王少斌　 陈曙光　 王瑜①　 冷希圣②　 陈慰峰①.MAGE-10基因在肝细胞肝癌中的表达及临床意义[J].中国微创外科杂志,2002,02(6):419-421.
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MAGE-10基因在肝细胞肝癌中的表达及临床意义()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
02
期数:
2002年6期
页码:
419-421
栏目:
基础研究
出版日期:
2002-12-31

文章信息/Info

Title:
Expression of MAGE-10 genes in human hepatocellular carcinoma and its clinical significance
作者:
赵海涛　 芮静安　 赵屹①　 王少斌　 陈曙光　 王瑜①　 冷希圣②　 陈慰峰①
北京协和医院基本外科,北京,100032
关键词:
MAGE-10基因 肝细胞肝癌
分类号:
R735.7;R730.3
文献标志码:
A
摘要:
目的探讨 MAGE-10基因与肝细胞肝癌(HCC)患者临床指标及转移复发的关系. 方法用RT-PCR的方法测定31例HCC癌组织及相应癌旁组织和10例肝硬化组织MAGE-10基因表达,对全部RT-PCR扩增产物中目的基因片段进行DNA测序以证实其为 MAGE-10基因,31例HCC测定AFP、岩藻糖苷酶(AFU)、抗HCV、HBsAg、AFPmRNA、肿瘤直径等临床指标. 结果 31例HCC组织中MAGE-10基因表达的阳性率为51.6% (16/31),明显高于癌旁组织0% (0/31),(χ2=18.95,P＜0.01).HCC组织中MAGE-10基因表达的阳性率与血清AFP、AFU、抗HCV、HBsAg、AFPmRNA水平及肿瘤大小无关(P>0.05).10例肝硬化组织中未见MAGE-10基因的表达. 结论 MAGE-10基因在HCC组织中特异高表达,其阳性率与HCC患者肿瘤标志物无关.

参考文献/References:

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备注/Memo

备注/Memo:
①（北京大学基础医学院免疫学系）②（北京大学人民医院外科）
更新日期/Last Update: 2014-07-31