[1]刘鹏①　 陈训如　 罗丁　 毛静熙　 吴辉　 王跃力.CO2气腹对肝硬变大鼠门脉血流影响的实验研究[J].中国微创外科杂志,2002,02(1):56-57.
　LiuPeng,ChenXunru,Luo Ding,et al.Experimental Study on Influence of CO2 Pneumoperitoneum on portal venous flow in rats with cirrhosis[J].Chinese Journal of Minimally Invasive Surgery,2002,02(1):56-57.
点击复制

CO2气腹对肝硬变大鼠门脉血流影响的实验研究()
分享到：

《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
02
期数:
2002年1期
页码:
56-57
栏目:
基础研究
出版日期:
2002-02-28

文章信息/Info

Title:
Experimental Study on Influence of CO2 Pneumoperitoneum on portal venous flow in rats with cirrhosis
作者:
刘鹏①　 陈训如　 罗丁　 毛静熙　 吴辉　 王跃力
成都军区昆明总医院肝胆外科,昆明,650032
Author(s):
LiuPeng; ChenXunru; Luo Ding; et al.
Department ofHepatobiliary Surgery,Kunming GeneralHospital,Chengdu MilitaryArea,Kunming650032,China.
关键词:
气腹; 肝硬变; 门静脉血流
Keywords:
Pneumoperitoneum　　Cirrhosis　　Portal venous flow
分类号:
R-332
文献标志码:
A
摘要:
目的探讨CO2气腹对肝硬变大鼠门脉血流量的影响. 方法制作肝硬变大鼠模型,施加不同压力的气腹,分别测平均动脉压、门静脉压力、下腔静脉压、门静脉血流,计算门静脉阻力. 结果平均动脉压、下腔静脉压在不同气腹压力下无明显变化,两组大鼠门静脉压力在10mmHg时出现显著差异,随着压力的升高而升高.正常大鼠的门静脉血流量在20mmHg下与0mmHg下比较有显著差异,而肝硬变大鼠的门静脉血流量在10mmHg下与0mmHg下比较已有显著差异.正常大鼠门静脉阻力随着压力的升高在10mmHg时出现显著差异,以后继续升高,肝硬化大鼠门静脉阻力随着压力的升高持续升高. 结论 CO2气腹致肝硬化大鼠门静脉血流减少,且减少程度重于正常大鼠.
Abstract:
Objective　To elucidate the effects of CO2pneumoperitoneum on the flowof portal vein in the ratswith cirrhosis.　Meth- ods　We replicated cirrhosis rat model and established CO2pneumoperitoneum of different pressures. The mean arterial pressure(MAP), por- tal pressure(PP), inferior vena cava pressure(IVCP), portal venous flow(PVF) were determined differently. The portal vascular resistance (PVR) was calculated.　Results　(1)MAP and IVCP did not change significantly at different pressures. PP changed significant at 10mmHg and increasedwiththe rise of pressure in both groups. (2) The blood flowof portal vein in the control group decreased significantly at 20mmHg of pressure compared with the flow at 0mmHg of pressure, but in the cirrhosis group it decreased remarkably at 10 mmHg compared with the flow at 0mmHg. (3) The PVR in the control group showed the a significant differencte. At the same time, the PVR in the cirrhosis group in- creased continuously with the increasing pressure.　Conclusions　CO2pneumoperitoneum led to the decrease of PVF in the cirrhosis rats and the level of decrease was more significant than that in the control group.

参考文献/References:

［1］吴孟超,杨广顺. 大鼠肝硬变模型复制的研究. 中华实验外科杂志,1984,1( 4):145-146
［2］张剑,周怀文. 一氧化氮在肝硬变门静脉高压症形成中的作用及其对血流动力学的影响. 中华外科杂志,1998,36:317-319.
［3］Lee FA, Colombato LA, Albillos A, et al. Administration of Nω-nitrol-l -arginine ameliorates portal-systemic shunting in portal-hypertensive rats. G astroenterology, 1993, 105:1464-1470.
［4］Lawrence N, Diebel MD, Robert F, et al. Effects of increased intra-abdomina l pressure on hepatic arterial, portal venous and hepatic microcirculation blood flow. J Trauma, 1992, 33:279-283.
［5］Dexter SP, Vucevic M, Gibson J, et al. Hemodynamic consequences of high-and low-pressure capnoperitoneum curing laparoscopic cholecystectomy. Surg Endosc, 1999, 13:376-381.
［6］Wittgen CM, Andrus CH, Fitzgerald SD, et al. Analysis of the hemodynamic and ventilatory effects lf laparoscopic cholecystectomy. Arch Surg 1991, 126:997-1 000.
［7］Tsugawa K, Hashizume M, Migou S, et al. The effect of carbon dioxide pneumop eritomeum on the portal hemodynamics in a portal-hypertensive rat model. Surg L aparosc Endosc & Percut Tech. 1999, 9:338.
［8］Angelo L, Isabel C, et al. Hemodynamic effects of acute changes in intra-ab dominal pressure in patients with cirrhosis. Gastroenterology 1993, 104:222-227 .
［9］Hamilton BD, Chow Ck, Jnman SR, et al. Increased imtra-abdominal pressure d uring pneumoperitoneum stimulates endothelin release in a canine model. J Eneour ol, 1998, 12:193-7.
［10］M.J. Tunon, P.Gonzalez, F.Jorquera, et al. Liver blood flow changes during laparoscopic surgery in pigs. Surg Endosc 1999, 13:668-672.

备注/Memo

备注/Memo:
①（第三军医大学硕士研究生）
更新日期/Last Update: 2014-07-18