[1]杜毅鹏,葛欣宜,周晨,等.支气管肺泡灌洗在自身免疫特征的间质性肺炎与结缔组织病相关间质性肺疾病中的应用[J].中国微创外科杂志,2018,18(3):220-224.
　Du Yipeng,Ge Xinyi,Zhou Chen,et al.Application of Bronchoalveolar Lavage in Interstitial Pneumonia With Autoimmune Features and Connective Tissue Disease-associated Interstitial Lung Disease[J].Chinese Journal of Minimally Invasive Surgery,2018,18(3):220-224.
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支气管肺泡灌洗在自身免疫特征的间质性肺炎与结缔组织病相关间质性肺疾病中的应用()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
18
期数:
2018年3期
页码:
220-224
栏目:
临床研究
出版日期:
2018-05-01

文章信息/Info

Title:
Application of Bronchoalveolar Lavage in Interstitial Pneumonia With Autoimmune Features and Connective Tissue Disease-associated Interstitial Lung Disease
作者:
杜毅鹏; 葛欣宜; 周晨; 张雪阳; 沈宁**; 贺蓓
北京大学第三医院呼吸科，北京100191
Author(s):
Du Yipeng;  Ge Xinyi;  Zhou Chen;  et al.
Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China
关键词:
支气管肺泡灌洗液; 自身免疫特征的间质性肺炎; 结缔组织病相关间质性肺疾病; 临床特征
Keywords:
Bronchoalveolar lavage fluid; Interstitial pneumonia with autoimmune features; Connective tissue diseaseassociated interstitial lung disease; Clinical characteristics
文献标志码:
A
摘要:
目的探讨自身免疫特征的间质性肺炎（interstitial pneumonia with autoimmune features，IPAF）与结缔组织病相关间质性肺疾病（connective tissue diseaseinterstitial lung disease，CTDILD）中支气管肺泡灌洗液（bronchoalverolar lavage fluid，BALF）细胞分类计数及其他临床特征的异同。方法回顾性分析2014年1月~2017年12月我科行支气管肺泡灌洗检查的间质性肺疾病47例的临床资料，其中CTDILD组28例（干燥综合征12例，类风湿关节炎4例，肌炎/皮肌炎11例，系统性硬化1例），IPAF组19例。比较2组临床表现、BALF特征、肺功能及影像学表观等的差异。结果CTDILD组BALF中性粒细胞计数较IPAF组显著增高［中位数2.27(0.03~18.90)×104/ml vs. 0.60(0.09~5.19)×104/ml, Z=-2.613, P=0009］。CTDILD组比IPAF组更年轻［(56±13)岁vs. (65±10)岁, t=-2.546,P=0.014］，皮肤表现多［46%(13/28) vs. 11%(2/19), χ2=6.714, P=0.010］，干燥症状少［18%(5/28) vs. 53%(10/19), χ2=6.299,P=0.012］。2组性别构成、其他症状、肺功能无显著性差异（P>0.05）。2组血清学自身抗体及影像学表现均无显著性差异（P>0.05）。结论BALF中性粒细胞升高可能是CTDILD区别于IPAF的特异性表现。
Abstract:
ObjectiveTo explore the characteristics of bronchoalverolar lavage fluid (BALF) cytology and clinical features of patients in interstitial pneumonia with autoimmune features (IPAF) and connective tissue diseaseassociated interstitial lung disease (CTDILD).MethodsA retrospective analysis was performed in 47 cases of interstitial lung disease admitted to our hospital and received bronchoalverolar lavage from January 2014 to December 2017, including 28 patients with CTDILD ［12 cases of Sjgren’s syndrome (SS), 4 cases of rheumatoid arthritis(RA), 11 cases of polymyositis/dermatomyositis (PM/DM) and 1 case of systemic sclerosis (SSc)］ and 19 patients with IPAF. Clinical manifestations, BALF cytology, pulmonary function and radiological features were compared between CTDILD and IPAF.ResultsPatients with CTDILD had a significant higher neutrophil counts as compared with patients with IPAF ［median, 2.27 (0.03-18.90)×104/ml vs. 0.60 (0.09-5.19)×104/ml, Z=-2.613, P=0.009］. As compared with patients with IPAF, patients with CTDILD were younger ［(56±13) years old vs. (65±10) years old, t=-2.546, P=0014］, had more skin lesions ［46% (13/28) vs. 11% (2/19), χ2=6.714, P=0.010］ and fewer dry symptoms ［18%(5/28) vs. 53%(10/19), χ2=6.299, P=0.012］. The difference of gender composition,other symptoms, lung function, serum autoantibodies and radiological features between the two groups did not show statistical significance (P>0.05).ConclusionAn increase of neutrophilia counts in BALF may contribute to the early identification of CTDILD as compared to IPAF.

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备注/Memo

备注/Memo:
基金项目：北京大学第三医院种子基金**通讯作者，E-mail:shenning1972@126.com
更新日期/Last Update: 2018-05-10