[1]杨飖,朱江帆*,马颖璋,等.腹腔镜胃袖状切除术对肥胖伴亚临床甲状腺功能减退症的影响[J].中国微创外科杂志,2017,17(10):893-896.
　Yang Yao,Zhu Jiangfan,Ma Yingzhang,et al.Influence of Laparoscopic Sleeve Gastrectomy on Obesity with Subclinical Hypothyroidism[J].Chinese Journal of Minimally Invasive Surgery,2017,17(10):893-896.
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腹腔镜胃袖状切除术对肥胖伴亚临床甲状腺功能减退症的影响()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
17
期数:
2017年10期
页码:
893-896
栏目:
临床研究
出版日期:
2017-10-20

文章信息/Info

Title:
Influence of Laparoscopic Sleeve Gastrectomy on Obesity with Subclinical Hypothyroidism
作者:
杨飖; 朱江帆*; 马颖璋; 唐霖; 张启颖; 张亚丽; 李王莺
同济大学附属东方医院糖尿病与减重外科，上海200123
Author(s):
Yang Yao;  Zhu Jiangfan;  Ma Yingzhang;  et al.
Department of Bariatric Surgery, East Hospital Affiliated to Medical School of Tongji University, Shanghai 200123, China
关键词:
亚临床甲状腺功能减退症; 胃袖状切除术; 代谢综合征; 肥胖症
Keywords:
Subclinical hypothyroidism; Sleeve gastrectomy; Metabolic syndrome; Morbid obesity
文献标志码:
A
摘要:
目的探讨腹腔镜胃袖状切除术对肥胖伴亚临床甲状腺功能减退症（subclinical hypothyroidism，SCH）的影响。方法回顾性分析2014年7月~2015年6月69例接受腹腔镜胃袖状切除术的肥胖（体重指数26~45.7）患者的临床资料，14例（20.3%）合并SCH（SCH组），另55例（79.7%）未合并SCH（非SCH组）。比较2组术前促甲状腺激素及相关代谢指标，以及SCH组手术前后促甲状腺激素及相关代谢指标。结果术前SCH组57.1%(8例)合并代谢综合征（metabolic syndrome，MS），非SCH组为291%（16例）；SCH组术前促甲状腺激素（thyroid stimulating hormone，TSH）（6.07±1.68）μIU/ml，术后12个月降至（2.88±0.56）μIU/ml（t=7.113，P=0.000）。结论腹腔镜胃袖状切除术可能促使促甲状腺激素下降，改善肥胖伴SCH。
Abstract:
ObjectiveTo analyze the influence of laparoscopic sleeve gastrectomy on obesity with subclinical hypothyroidism (SCH).MethodsA total of 69 clinical cases of obese patients (BMI, 26-45.7) who underwent laparoscopic sleeve gastrectomy in our hospital from July 2014 to June 2015 were retrospectively analyzed. Among these patients there were 14 cases (20.3%) with SCH (SCH group) and 55 cases (79.7%) without SCH (non-SCH group). The thyroid hormones and related metabolic indexes preoperatively and postoperatively were compared between these two groups.ResultsPreoperative data showed that the SCH group had 8 cases (57.1%) combined with metabolic syndrome and the non-SCH group had 16 cases (29.1%) combined with metabolic syndrome. Twelve months after surgery the average thyroid stimulating hormone(TSH) level was significantly dropped from (6.07±168) μIU/ml preoperatively to (2.88±0.56) μIU/ml (t=7.113, P=0.000) in the SCH group.ConclusionLaparoscopic sleeve gastrectomy may lead to a decrease in thyroid stimulating hormone, which is expected to significantly benefit obese patients with SCH.

参考文献/References:

[1]褚晓秋,刘超.2012 ATA/AACE《成人甲减的诊治指南》解读.中华内分泌代谢杂志,2013,29（6）:增录6a1-6a4.
[2]Ruiz-Tovar J,Boix E,Galindo I,et al.Evolution of subclinical hypothyroidism and its relation with glucose and triglycerides levels in morbidly obese patients after undergoing sleeve gastrectomy as bariatric procedure.Obes Surg,2014,24(5):791-795.
[3]Pearce SH,Brabant G,Duntas LH,et al.2013 ETA Guideline：management of subclinical hypothyroidism.Eur Thyroid J,2013,2(4):215-228.
[4]彭小莲,韩劲松.多囊卵巢综合征与代谢综合征.中国微创外科杂志,2014,14（1）:77-80.
[5]王恺京,忻颖,周小钢,等.腹腔镜胃袖状切除对多囊卵巢综合征生殖内分泌功能改善的作用.中国微创外科杂志,2014,14(10):942-944.
[6]Baumgartner C,Blum MR,Rodondi N.Subclinical hypothyroidism:summary of evidence in 2014.Swiss Med Wkly,2014,144:w14058.
[7]Rotondi M,Leporati P,La Manna A,et al.Raised serum TSH levels in patients with morbid obesity:is it enough to diagnose subclinical hypothyroidism?Eur J Endocrinol,2009,160（3）:403-408．
[8]Moulin de Moraes CM,Manrini MC,de Melo ME,el al.Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass.Obes Surg,2005,15（9）:1287-1291．
[9]Knudsen N,Laurberg P,Rasmussen LB,et al.Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population.J Clin Endocrinol Metab,2015,90(7):4019-4024．
[10]Nyrnes A,Jorde R,Sundsfjord J.Serum TSH is positively associated with BMI.Int J Obes(Land),2006,30(1):100-105．
[11]Ambrosi B,Massefini B,Iorio L,et al.Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects.J Endocrinol Invest,2010,33(9):640-643.
[12]Radetti G,Kleon W,Buzi F,et al.Thyroid function and structure are affected in childhood obesity.J Clin Endocrinol Metab,2008,93(12):4749-4754．
[13]Waring AC,Rodondi N,Harrison S,et al.Thyroid function and prevalent and incident metabolic syndrome in older adults：the Health,Ageing and Body Composition Study.Clin Endocrinol (Oxf),2012,76(6):911-918．
[14]胡颖,时立新,孙雪明,等.血清促甲状腺激素与代谢综合征及其组分的相关性.中华内分泌代谢杂志,2013,29(7):560-562.

备注/Memo

备注/Memo:
*通讯作者，E-mail：zhujiangfan@hotmail.com
更新日期/Last Update: 2018-01-11