[1]胡杰*①,陈胜阳,王更富,等.舒芬太尼替代芬太尼应用于分娩镇痛的安全性分析[J].中国微创外科杂志,2017,17(07):650-652.
　Hu Jie,Chen Shengyang*,Wang Gengfu*,et al.Safety Analysis of Labour Analgesia with Sufentanil Instead of Fentanyl[J].Chinese Journal of Minimally Invasive Surgery,2017,17(07):650-652.
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舒芬太尼替代芬太尼应用于分娩镇痛的安全性分析()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
17
期数:
2017年07期
页码:
650-652
栏目:
新技术新方法
出版日期:
2017-07-20

文章信息/Info

Title:
Safety Analysis of Labour Analgesia with Sufentanil Instead of Fentanyl
作者:
胡杰*①; 陈胜阳; 王更富; 张永强
新乡医学院第一附属医院麻醉科，卫辉453000
Author(s):
Hu Jie;  Chen Shengyang*;  Wang Gengfu*;  et al.
*Department of Anesthesiology, First Affiliated Hospital of Xinxiang Medical College, Weihui 453000, China
关键词:
舒芬太尼; 无痛分娩; 芬太尼
Keywords:
Sufentanil;  Painless labour;  Fentanyl
文献标志码:
A
摘要:
目的探讨舒芬太尼替代芬太尼在无痛分娩应用的安全性和可行性。方法将2014年8月-2016年2月在我院接受自然生产的初产妇300例，按患者入院的先后顺序及意愿选择分娩方式分为芬太尼组、舒芬太尼组和对照组3组，每组100例。对照组自然生产，芬太尼组、舒芬太尼组分别采用芬太尼和舒芬太尼无痛分娩，产程若出现宫缩乏力加滴缩宫素。观察总产程时间，视觉模拟评分（visual analogue scale, VAS）进行疼痛评分，并发症，新生儿Apgar 1、10 min评分。结果总产程时间对照组明显短于芬太尼组［（402.8±81.9）min vs. (476.5±84.8）min，q=9.185,P<0.05］；疼痛VAS评分舒芬太尼组、芬太尼组明显低于对照组［(3.0±0.7) 分vs.（7.1±0.7）分，q=58.571, P<0.05；(3.3±0.7)分vs.（7.1±0.7）分，q=54.286,P<0.05］。3组产后并发症发生率无统计学差异（χ2=0.150，P=0.928）。3组新生儿Apgar 1、10 min评分有统计学差异（P＜0.05），但都在8分以上，差异无实际临床意义。结论舒芬太尼应用于无痛分娩时联合缩宫素能获得满意的镇痛效果，安全有效。
Abstract:
ObjectiveTo study the effect of sufentanil instead of fentanyl applied in painless labour in pregnant women.MethodsA total of 300 primiparas in our hospital were selected as subjects, and randomly assigned to a control group (C) or two treatment groups (F or S groups), with 100 in each group. The C group had natural delivery. The S and F groups were treated with sufentanil and fentanyl in painless labour,respectively. The labour time, VAS scores, complications, and Apgar scores at 1 and 10 min were recorded. ResultsThe labour time was significantly shorter in the C group than the F group ［(402.8±81.9) min vs. (4765±84.8) min, q=9.185, P<0.05］. The VAS scores were significantly lower in the S and F groups than that in the C group ［(3.0±0.7) points vs. (7.1±0.7) points, q=58.571, P<0.05; (3.3±0.7) points vs. (7.1±0.7) points , q=54.286, P<0.05］. There was no significant difference among the three groups in postoperative complications (χ2=0.150, P=0.928). The neonatal Apgar scores among the three groups at 1 min and 10 min had significant differences (P<0.05), all of which were above 8 points, without clinical significance. ConclusionSufentanil applied in painless labour in pregnant women is safe and effective.

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备注/Memo

备注/Memo:
*通讯作者，E-mail：13721624858@163.com①（郑州大学附属洛阳中心医院麻醉科，洛阳471000）
更新日期/Last Update: 2017-09-21