[1]刘冰川 孙川 侯国进 杨钟玮 刘忠军 田耘 周方**.3D打印技术的临床应用：基于“精准骨科”的四肢骨缺损重建[J].中国微创外科杂志,2021,01(4):303-308.
　Liu Bingchuan,Sun Chuan,Hou Guojin,et al.Clinical Application of 3D Printing Technology: Bone Defect Reconstruction of Limbs Based on “Precision Orthopaedics”[J].Chinese Journal of Minimally Invasive Surgery,2021,01(4):303-308.
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3D打印技术的临床应用：基于“精准骨科”的四肢骨缺损重建()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
01
期数:
2021年4期
页码:
303-308
栏目:
临床研究
出版日期:
2021-04-25

文章信息/Info

Title:
Clinical Application of 3D Printing Technology: Bone Defect Reconstruction of Limbs Based on “Precision Orthopaedics”
作者:
刘冰川 孙川 侯国进 杨钟玮 刘忠军 田耘 周方**
（北京大学第三医院骨科骨与关节精准医学教育部工程研究中心，北京100191）
Author(s):
Liu Bingchuan;  Sun Chuan;  Hou Guojin;  et al.
Department of Orthopaedics, Peking University Third Hospital, Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China
关键词:
3D打印技术; 骨缺损; 临床应用; 精准医疗
Keywords:
3D printing technology; Bone defect; Clinical application; Precision medicine
文献标志码:
A
摘要:
目的探讨3D打印技术在四肢骨缺损治疗中的可行性及有效性。方法选择2018年1月~2019年10月15例骨缺损。骨髓炎12例，无菌性骨不愈合3例。骨缺损部位包括股骨合并胫骨1例，股骨7例，胫骨6例，肱骨1例。骨缺损长6~31.2 cm，中位数12.7 cm。在彻底清创及控制感染的前提下，应用3D打印钛合金假体重建骨缺损。常规复查X线及CT，定量评价指标包括疼痛视觉模拟量表（Visual Analogue Scale，VAS）、日常生活能力量表(Activity of Daily Living Scale，ADL)、上肢功能量表（Disability of Arm, Shoulder and Hand，DASH）、下肢功能量表（Lower Extremity Functional Scale，LEFS）及患者满意度评分。结果2例骨髓炎感染复发。余13例无感染复发、内固定及假体松动断裂，平均随访18.0月（12~26个月），末次随访日常生活肢体疼痛VAS评分平均2.4分（2~4分），ADL评分94.2分（90~95分），1例肱骨缺损患者DASH评分31.7分，12例下肢骨缺损患者LEFS评分42.0分（38~47分），满意度9.3分（9.1~9.5分）。结论3D打印技术治疗四肢骨缺损可实现假体稳定及新骨再生，患者可获得较满意的肢体功能恢复。
Abstract:
ObjectiveTo explore the feasibility and effectiveness of 3D printing technology in the treatment of bone defects of limbs.MethodsA prospective study was made on 15 patients with bone defect from January 2018 to October 2019. There were 12 cases of osteomyelitis and 3 cases of aseptic nonunion. Their bone defect sites included 1 case of femur combined with tibia, 7 cases of femur, 6 cases of tibia, and 1 case of humerus. The length of bone defect ranged from 6 to 31.2 cm, with a median of 12.7 cm. Under the premise of thorough debridement and infection control, we applied 3D printed Ti6Al4V prostheses to repair bone defects. Regular followups included Xray and CT scanning, and quantitative assessment indexes included the Visual Analogue Scale (VAS), Activity of Daily Living Scale (ADL), Disability of Arm, Shoulder and Hand (DASH), Lower Extremity Functional Scale (LEFS) and satisfaction degree. ResultsThere were 2 cases of recurrence of osteomyelitis. The remaining 13 patients had no recurrence of infection, internal fixation or prosthesis loosening or fracture. The average followup period was 18.0 months (range, 12-26 months). At the last followup, the average VAS score of daily life limb pain was 2.4 (2-4), the ADL score was 94.2 (90-95), the DASH score was 31.7 points in 1 case of humeral defect, the LEFS score was 42.0 (38-47) in 12 cases of lower limb bone defect, and the satisfaction score was 9.3 (9.1-9.5).Conclusion3D printing technology has good potential for clinical application for treating bone defects of limbs, which can realize prosthesis stabilization and new bone regeneration, and patients can obtain satisfactory limb function recovery.

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备注/Memo

备注/Memo:
基金项目：国家重点研发计划政府间国际科技创新重点合作专项（SQ2018YFGH000080）；首都临床特色应用研究（Z181100001718195）**通讯作者，Email：zhouf@bjmu.edu.cn
更新日期/Last Update: 2021-06-30