[1]蔡丽生 陈秋贤** 方顺勇 连明桥 沈俊涛 洪建明.甲状腺微小乳头状癌手术126例体会[J].中国微创外科杂志,2017,17(09):772-774.
 Cai Lisheng,Chen Qiuxian,Fang Shunyong,et al.Treatment of 126 Cases of Thyroid Microcarcinoma[J].Chinese Journal of Minimally Invasive Surgery,2017,17(09):772-774.
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甲状腺微小乳头状癌手术126例体会()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
17
期数:
2017年09期
页码:
772-774
栏目:
临床论著
出版日期:
2017-09-20

文章信息/Info

Title:
Treatment of 126 Cases of Thyroid Microcarcinoma
作者:
蔡丽生 陈秋贤** 方顺勇 连明桥 沈俊涛 洪建明
福建医科大学附属漳州市医院普外二科,漳州363000
Author(s):
Cai Lisheng Chen Qiuxian Fang Shunyong et al.
Department of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China
关键词:
甲状腺腺叶切除术颈淋巴结清扫术甲状腺微小癌
Keywords:
ThyroidectomyCervical lymph node dissectionThyroid microcarcinoma
文献标志码:
A
摘要:
目的探讨甲状腺微小乳头状癌手术的治疗方法。方法2015年1月~2016年5月,我科收治甲状腺微小癌126例,行患侧加峡部切除或甲状腺全切除术及中央区淋巴结清扫术,中央区淋巴结转移者行同侧选择性区域淋巴结清扫术。统计手术并发症、术后病理及恢复情况。结果发现隐匿性多发癌4例;术中证实中央区转移45例(35.7%),行横行小切口侧颈区选择性区域淋巴结清扫术(清扫Ⅱ、Ⅲ、Ⅳ、部分Ⅴ区),术后病理侧颈区淋巴结转移23例。术后声音嘶哑3例,饮水呛咳2例,短暂性低钙血症15例(均为甲状腺全切除术后),术后乳糜淋巴漏4例(均为侧颈区淋巴结清扫术后)。无术后切口出血导致再次手术。结论甲状腺微小癌具有较高的中央区淋巴结转移率,中央区淋巴结转移者侧颈区淋巴结转移率高,建议对甲状腺微小癌行常规小切口甲状腺全切除及选择性区域淋巴结清扫术。
Abstract:
ObjectiveTo explore the optimal surgical treatment of thyroid microcarcinoma.MethodsClinical data of 126 patients with thyroid microcarcinoma underwent total thyroidectomy or lobectomy and isthmusectomy in our hospital from January 2015 to May 2016 were analyzed retrospectively. All patients routinely received central compartment lymph node dissection, and an additional prophylactic lateral cervical lymph node dissection was performed for tumor side in patients with central compartment lymph node metastasis. Surgical complications, postoperative pathologic results and postoperative recovery were evaluated.ResultsMultiple occult carcinoma was found in 4 cases. Central compartment lymph node metastasis occurred in 35.7% (45/126) of patients confirmed during operation, which were given prophylactic lateral cervical lymph node dissection through a small infestative skin incision (the Ⅱ, Ⅲ, Ⅳ regions and partial Ⅴ region). A total of 23 cases were found with lateral cervical lymph node metastasis. Postoperatively there were 3 cases of hoarseness, 2 cases of cough when drinking water, 15 cases of temporary hypocalcemia (after total thyroidectomy), and 4 cases of lymphatic leakage (after prophylactic lateral cervical lymph node dissection). There was no re-operation due to postoperative hemorrhage.ConclusionsThe incidence of central compartment lymph node metastasis is relatively high in patients with thyroid microcarcinoma, resulting in high rate of the lateral cervical lymph node metastasis. Thus, total thyroidectomy combined with cervical regional lymph node dissection should be recommended for patients with thyroid microcarcinoma.

参考文献/References:

[1]张金庆,顾禾.甲状腺乳头状微小癌的诊断及外科治疗进展.中华肿瘤防治杂志,2014,21(24):2008-2011.
[2]谭石,姚宏伟,贾建文,等.超声引导下细针穿刺在甲状腺小结节诊断中的应用.中国微创外科杂志,2014,14(12):1065-1067.
[3]Wu LS,Milan SA.Management of microcarcinomas (papillary and medullary) of the thyroid. Curr Opin Oncol,2013,25(1):27-32.
[4]He Q,Zhuang D,Zheng L,et al.The surgical management of papillary thyroid microcarcimoma:a 162-month single-center experience of 273 cases.Am Surg,2012,78(11):1215-1218.
[5]尹国锋.甲状腺微小乳头状癌的外科治疗.实用医学杂志,2015,31(5):791-792.
[6]袁华芳,蒋天安,赵齐羽,等.超声引导下细针穿刺细胞学检查对长径≤5 mm甲状腺微小癌的诊断价值.中国微创外科杂志,2016,16(2):151-157.
[7]Glockzin G,Homung M,Kienle K,et al.Completion thyroidectomy: effect of timing on clinical complications and oncologic outcome in patients with differentiated thyroid cancer.World J Surg,2012,36(5):1168-1173.
[8]滕卫平,刘永锋,高明,等.甲状腺结节和分化型甲状腺癌诊治指南.中国肿瘤临床,2012,39(17):1249-1272.
[9]Brown RF,Ducic Y.Aggressive surgical resection of anaplastic thyroid carcinoma may provide long-term survival in selected patients.Otolaryngol Head Neck Surg,2013,148(4):564-571.
[10]Matsuzu K,Sugino K,Masudo K,et al.Thyroid lobectomy for papillary thyroid cancer: long-term follow-up study of 1,088 cases.World J Surg,2014,38(1):68-79.
[11]Nixon IJ,Ganly I,Patel SG,et al.Thyroid lobectomy for treatment of well differentiated intrathyroid malignancy.Surgery,2012,151(4):571-579.
[12]Kim KB,Cabanillas ME,Lazar AJ,et al.Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF (V600E) mutation.Thyroid,2013,23(10):1277-1283.
[13]Cooper DS,Doherty GM,Haugen BR,et al.Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.Thyroid,2009,19(11):1167-1214.
[14]NCCN Clinical Practice Guidelines in Oncology.Thyroid carcinoma.Version 2.2012.http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf

备注/Memo

备注/Memo:
基金项目:福建省卫生厅青年科研课题(编号:2015-2-29)**通讯作者,E-mail:4626033@qq.com
更新日期/Last Update: 2017-11-27