[1]陆京京,丁士刚,张莉,等.细胞周期素D1(cyclin D1)和Ki67蛋白在食管鳞癌组织中的表达及临床意义[J].中国微创外科杂志,2009,09(11):983-991.
　Lu Jingjing,Ding Shigang,Zhang Li,et al.Expressions of Cyclin D1 and Ki67 in Esophageal Squamous Cell Carcinoma and Their Clinical Significance[J].Chinese Journal of Minimally Invasive Surgery,2009,09(11):983-991.
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细胞周期素D1(cyclin D1)和Ki67蛋白在食管鳞癌组织中的表达及临床意义()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
09
期数:
2009年11期
页码:
983-991
栏目:
论著
出版日期:
2009-11-30

文章信息/Info

Title:
Expressions of Cyclin D1 and Ki67 in Esophageal Squamous Cell Carcinoma and Their Clinical Significance
作者:
陆京京; 丁士刚; 张莉; 金珠; 韩亚京
北京大学第三医院消化科，北京100191
Author(s):
Lu Jingjing;  Ding Shigang;  Zhang Li;  et al.
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
关键词:
食管鳞癌; cyclin D1; Ki67; 食管炎
Keywords:
Esophageal squamous cell carcinoma; Cyclin D1; Ki67; Esophagitis
分类号:
R735.1
文献标志码:
A
摘要:
目的探讨细胞周期素D1(cyclin D1)、Ki67蛋白在食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）中的表达及其临床意义。方法应用免疫组化方法检测28例ESCC组织和33例食管炎组织中cyclin D1蛋白、Ki67蛋白的表达。结果在ESCC与食管炎组织中cyclin D1阳性表达率分别为60.7%(17/28)和33.3％(11/33)（χ2=4.573，P=0032），Ki67标记指数(Ki67 LI)分别为（49.21±25.15）%和（11.62±9.87）%(t=7.908，P=0.000)。ESCC组TNM分期中Ⅰ期cyclin D1阳性表达率为14.3%(1/7)，Ⅱ期为５５６%（５/9），Ⅲ期为85.7%(6/7)，Ⅳ期为100％(5/5)，Ⅲ期与Ⅰ期、Ⅳ期与Ⅰ期相比，差异有显著性（P值分别为0.029，0.015)。有淋巴结转移者cyclin D1阳性表达率为90.9%(10/11)，无淋巴结转移者为41.2%(7/17)（P=0.016)。28例ESCC随访6~34个月，（250±42）月，死亡4例（3例为原发病进展，1例脑血管意外），生存19例，失访5例。 结论cyclin D1的表达与进展期肿瘤、淋巴结转移有关。Ki67在肿瘤中高表达，表达强弱与肿瘤分化程度及肿瘤分期无关。
Abstract:
ObjectiveTo estimate the expressions of cyclin D1 and Ki67 in esophageal squamous cell carcinomas and their clinical significance.MethodsThe expressions of cyclin D1 and Ki67 were detected by immunohistochemistry in 28 specimens esophageal squamous cell carcinoma (ESCC) and 33 samples esophagitis tissue. ResultsThe positive expression rate of cyclin D1 in ESCC and esophagitis tissues was 60.7% (17/28) and 33.3% (11/33) respectively (χ2=4.573, P=0.032), while the mean Ki67 label index (Ki67 LI) was （49.21±25.15）% and （11.62±9.87）% respectively (t=7.908, P=0.000). The positive expression rate of cyclin D1 in TNM stage I tissues was 14.3% (1/7), which was significantly lower than that in stages Ⅲ and Ⅳ tissues［85.7% (6/7) and 100% (5/5), P=0.029 and 0.015, respectively］. In cases with lymph node metastasis, the positive rate of cyclin D1 expression was 90.9% (10/11) that was significantly higher than that in those without lymph node metastasis (P=0.016). The 28 patients with ESCC were followed up for 6 to 34 months ［mean, (25.0±4.2) months］, during which 19 patients survived, 4 patients died of deterioration of the primary diseases (3 cases) or cerebrovascular affair (1 case), and the other 5 patients was lost to followup.ConclusionsThe expression of cyclin D1 is correlated with advanced tumor and lymph node metastasis. The Ki67 is highly expressed in ESCC tissues; no relationship exists between the level of the expression and the pathological differentiation type and TNM stage of ESCC.

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备注/Memo

备注/Memo:
丁士刚通讯作者
更新日期/Last Update: 2014-01-08