[1]郭振东,颜丽,王晓文,等.热籽磁感应加温在离体组织中的升温情况[J].中国微创外科杂志,2009,09(6):495-497.
　Guo Zhendong,Yan Li,Wang Xiaowen,et al.Heating of Isolated Tissues by SelfRegulating Thermoseeds[J].Chinese Journal of Minimally Invasive Surgery,2009,09(6):495-497.
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热籽磁感应加温在离体组织中的升温情况()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
09
期数:
2009年6期
页码:
495-497
栏目:
实验研究
出版日期:
2009-08-01

文章信息/Info

Title:
Heating of Isolated Tissues by SelfRegulating Thermoseeds
作者:
郭振东; 颜丽; 王晓文; 唐劲天**
清华大学工程物理系医学物理与工程研究所,北京100084
Author(s):
Guo Zhendong;  Yan Li;  Wang Xiaowen;  et al.
Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, Beijing 100084, China
关键词:
热籽加热体系; 磁感应加热; 离体猪肝; 加热温度
Keywords:
Thermoseeds; Inductive heating; Isolated hepatic tissues; Temperature
分类号:
R-332
文献标志码:
A
摘要:
目的通过离体猪肝实验初步探索磁感应热疗的升温情况。方法将新鲜的离体猪肝均匀复温至37 ℃，与此同时将热籽和热电偶的测温端固定在木制的支架上，待复温完成将支架置入肝组织中，保证热籽与磁力线平行，在开启磁场加热的同时开始采集数据。磁场强度范围120～123 Gs，磁场频率范围113～116 kHz，加热30 min，保存采集到的温度-时间图线，进行分析。结果各测温点的升温幅度不尽相同，最高可达14 ℃，加热区域呈现白-黄-棕红的梯度颜色变化，且质地变硬。当热籽颗数相同时，温度与距离呈现良好的负相关关系（r=-0.96017~-0.99767，P=0.0023~0.0398）；当测温距离相同时，除中心测温组（r=0.93936，P=0.0606）外，其余各组温度与热籽颗数呈现正相关关系(r=0.93775~0.99270，P=0.0007~0.0185）。结论热籽加热体系在离体猪肝中可获得较好的加热效果，在一定程度上，热籽的数量越多、距离加热体系越近，所能达到的温度越高，温度的提升幅度也越大。
Abstract:
ObjectiveTo examine the heating capability of thermoseeds in isolated hepatic tissues.MethodsIsolated hepatic tissues were heated uniformly to 37 ℃, meanwhile the thermoseeds and thermocouples were planted using a template paralleling with the magnetic line. Afterwards, the tissues were treated in an extracorporeal magnetic field of 120-123 gauss at a frequency of 113-116 kHz for 30 minutes. At the meantime, the temperature was recorded by a computer through thermocouples. ResultsThe temperature of the tissues raised markedly with a largest change of 14 ℃. The heating area became hard and showed a gradual change of color (white-yellow-brown). The final temperature was negatively correlated with distance when using same number of the thermoseeds (r=-0.96017 to -0.99767, P=0.0023 to 0.0398), and positively correlated with the number of thermoseeds when measuring at a same point (r=0.93775 to 0.99270, P=0.0007 to 0.0185）except for the center group (r=0.93936, P=0.0606).ConclusionsThermoseeds inductive heating technology can achieve an appropriate temperature in isolated hepatic tissues. In certain extent, the temperature increase the number of thermoseeds and heating distance.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（10775085）；国家自然科学基金（30571779）；北京市科委（Z07000200540704）；清华大学裕元基金**通讯作者
更新日期/Last Update: 2014-01-08