[1]唐慧敏 赵艳**① 吴琼② 刘维**③.靶控输注临床常用浓度舒芬太尼的效能：前瞻性随机对照研究[J].中国微创外科杂志,2021,01(8):705-709.
　Tang Huimin*,Zhao Yan,Wu Qiong,et al.Performance of Targetcontrolled Infusion of Sufentanil at Commonly Used Concentration:a Prospective Randomized Controlled Trial[J].Chinese Journal of Minimally Invasive Surgery,2021,01(8):705-709.
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靶控输注临床常用浓度舒芬太尼的效能：前瞻性随机对照研究()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
01
期数:
2021年8期
页码:
705-709
栏目:
临床研究
出版日期:
2021-08-25

文章信息/Info

Title:
Performance of Targetcontrolled Infusion of Sufentanil at Commonly Used Concentration:a Prospective Randomized Controlled Trial
作者:
唐慧敏 赵艳**① 吴琼② 刘维**③
（北京大学第三医院麻醉科，北京100191）
Author(s):
Tang Huimin*;  Zhao Yan;  Wu Qiong;  et al.
*Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China
关键词:
靶控输注; 舒芬太尼; 全身麻醉
Keywords:
Targetcontrolled infusion; Sufentanil; General anesthesia
文献标志码:
A
摘要:
目的探讨靶控输注（targetcontrolled infusion，TCI）临床常用浓度（0.2 ~1.0 ng/ml）舒芬太尼的效能。方法择期全麻腔镜手术30例，ASAⅠ或Ⅱ级，年龄（43.8±12.5）岁。采用随机数序列法随机分为3组（n=10）：0.2 ng/ml组（Ⅰ组）、0.3 ng/ml组（Ⅱ组）和04 ng/ml组（Ⅲ组）。麻醉诱导和维持采用TCI舒芬太尼，复合吸入七氟烷维持麻醉。经桡动脉取血，液相色谱-质谱联用法测定舒芬太尼浓度。计算偏离度（median performance error，MDPE）、精确度（median absolute performance error，MDAPE）、摆动度和离散度。结果Ⅰ、Ⅱ、Ⅲ组MDPE分别是3.5%、8.1%和6.1%，MDAPE分别为254%、20.0%和25.7%，摆动度分别为23.1%、23.0%和24.5%，离散度分别为-0.309%/h、-0.007%/h和-0.586%/h。总体MDPE、MDAPE、摆动度和离散度分别为5.4%、22.5%、23.3%和-0.271%/h。结论临床常用浓度舒芬太尼TCI效能在临床可接受范围内，随时间延长TCI系统稳定性良好。舒芬太尼实测血药浓度较靶浓度高约5%，舒芬太尼浓度0.3 ng/ml更适合TCI。
Abstract:
ObjectiveTo investigate the performance of targetcontrolled infusion (TCI) of sufentanil at commonly used concentration (0.2-1.0 ng/ml) in general anesthesia. MethodsThirty patients with ASA Ⅰ or Ⅱ, aged (43.8±12.5) years old and scheduled for selective surgery under general anesthesia, were included in this study. The patients were divided into 3 groups with 10 cases in each group by using the computergenerated sequence of random numbers: 0.2 ng/ml group (groupⅠ), 0.3 ng/ml group (group Ⅱ) and 0.4 ng/ml group (group Ⅲ). Anesthesia was induced and maintained with sufentanil TCI, and the patients also inhaled sevoflurane during the maintenance of anesthesia. Arterial blood samples were collected, the concentration of sufentanil was determined by liquid chromatographymass spectrometry. The median performance error (MDPE), median absolute performance error (MDAPE), wobble, and divergence were calculated. ResultsIn the group Ⅰ, Ⅱ and Ⅲ, the MDPE of sufentanil TCI was 35%, 8.1% and 6.1%, the MDAPE was 25.4%, 20.0% and 25.7%, the wobble was 23.1%, 23.0% and 24.5%, and the divergence was -0.309%/h, -0.007%/h and -0.586%/h, respectively. The pooled MDPE, MDAPE, wobble and divergence were 5.4%, 22.5%, 23.3% and -0.271%/h, respectively.ConclusionsThe performance of sufentanil TCI at commonly used concentration in general anesthesia is within the clinically acceptable range, and the system of sufentanil TCI shows good stability along with time. The measured blood concentration of sufentanil is about 5% higher than the target concentration, so that a sufentanil concentration of 0.3 ng/ml is more suitable for TCI.

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备注/Memo

备注/Memo:
基金项目：北京大学第三医院中青年骨干基金项目（65476-01）**通讯作者，Email：zhaoyan2004@263.net（赵艳）；andthen0023@163.com（刘维）①（同济大学附属上海市第四人民医院麻醉与围术期医学科，上海200434）②（深圳市人民医院疼痛科，深圳518020）③（北京大学第三医院药剂科，北京100191）
更新日期/Last Update: 2021-11-04