[1]王晔 张宏娜 张静 刘鑫丁 士刚**.胃肠道原发与继发非霍奇金淋巴瘤临床及内镜特点的差异[J].中国微创外科杂志,2019,01(1):6-10.
　Wang Ye,Zhang Hongna,Zhang Jing,et al.Differences in Clinical and Endoscopic Characteristics Between Primary and Secondary Gastrointestinal NonHodgkin Lymphoma[J].Chinese Journal of Minimally Invasive Surgery,2019,01(1):6-10.
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胃肠道原发与继发非霍奇金淋巴瘤临床及内镜特点的差异()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
01
期数:
2019年1期
页码:
6-10
栏目:
临床论著
出版日期:
2019-01-25

文章信息/Info

Title:
Differences in Clinical and Endoscopic Characteristics Between Primary and Secondary Gastrointestinal NonHodgkin Lymphoma
作者:
王晔 张宏娜 张静 刘鑫丁 士刚**
（北京大学第三医院消化科，北京100191）
Author(s):
Wang Ye;  Zhang Hongna;  Zhang Jing;  et al.
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
关键词:
非霍奇金淋巴瘤; 临床特征; 内镜特点
Keywords:
NonHodgkin lymphoma; Clinical feature; Endoscopic feature
文献标志码:
A
摘要:
目的比较胃肠道原发与继发非霍奇金淋巴瘤（nonHodgkin’s lymphomas，NHLs）临床与内镜特点的差异。方法检索2010年5月~2017年5月我院住院患者病历资料。纳入标准：内镜及病理诊断确诊为胃肠道非霍奇金淋巴瘤。排除标准：临床、内镜资料不完整，没有进行系统的临床评估，无法确定是否为原发或继发胃肠道非霍奇金淋巴瘤。共纳入130例，其中原发组65例（男36例），（58.3±13.8）岁，继发组65例（男37例），（60.4±15.9）岁。比较人口统计学资料、受累部位、临床及内镜表现、病理类型、幽门螺杆菌（Helicobacter pylori）感染情况等指标。 结果临床表现上，原发组27例（41.5%）存在B组症状，继发组为39例（60.0%）（χ2=4.432,P=0.035）。病理类型上，2组最常见的均为弥漫大B细胞淋巴瘤，但黏膜相关淋巴组织（mucosa associated lymphoid tissue,MALT）淋巴瘤在原发组（20例，30.8%）明显高于继发组（2例，3.1%）（χ2=17.727,P=0000）。受累部位上，继发组结直肠受累（14例，21.5%）明显多于原发组（4例，6.2%）（χ2=6.448，P=0.011）。内镜下表现，2组胃部受累最常见表现均为溃疡型病变，而肠道受累最常见表现均为肿块型病变，2组无显著差异。原发组幽门螺杆菌阳性率为51.2%（21/41），继发组为30.4%（7/23），2组间无显著差异（χ2=2.587，P=0.108）。但在弥漫大B细胞淋巴瘤中，原发组幽门螺杆菌阳性率（59.1%，13/22）明显高于继发组（27.3%，6/22）（χ2=4.539,P=0.033）。结论与胃肠道原发非霍奇金淋巴瘤相比，继发非霍奇金淋巴瘤B组症状更常见，结直肠受累更常见，MALT淋巴瘤少见，幽门螺杆菌感染率低。
Abstract:
ObjectiveTo compare clinical and endoscopic characteristics of primary and secondary gastrointestinal nonHodgkin’s lymphomas (NHLs).MethodsMedical records of hospitalized patients in our hospital from May 2010 to May 2017 were collected. Inclusion criteria: patients diagnosed with gastrointestinal NHLs through endoscopic and pathological diagnosis. Exclusion criteria: incomplete clinical and endoscopic data, no systematic clinical evaluation and patients which primary or secondary gastrointestinal NHLs could not be determined. A total of 130 patients with gastrointestinal NHLs were enrolled, including 65 patients (36 males) in the primary group with an average age of (58.3±13.8) years old, and 65 patients (37 males) in the secondary group with an average age of (60.4±15.9) years old. Demographic data, involvement location, clinical and endoscopic manifestations, pathological types, Helicobacter pylori (H.Pylori) infection and other indicators were compared.ResultsClinically, 27 patients (41.5%) in the primary group had group B symptoms and 39 patients (60.0%) in the secondary group had group B symptoms (χ2=4.432, P=0.035). Pathologically, diffuse large Bcell lymphoma was the most common in both groups, but mucosa associated lymphoid tissue (MALT) lymphoma was significantly higher in the primary group (20 cases, 30.8%) than in the secondary group (2 cases, 3.1%) (χ2=17727, P=0.000). As for involvement location, colorectal involvement in the secondary group (14 cases, 215%) was significantly more than the primary group (4 cases, 6.2%）(χ2=6.448, P=0.011). The most common endoscopic manifestations of gastric involvement in both groups were ulcerative lesions, while the most common endoscopic manifestations of intestinal involvement were elevated lesions, with no significant difference between the two groups. The positive rate of H.pylori was 512% (21/41) in the primary group and 30.4% (7/23) in the secondary group, but there was no significant difference between the two groups (χ2=2.587, P=0.108). However, in diffuse large Bcell lymphoma, the H.pylori infection rate in the primary group (59.1%, 13/22) was significantly higher than that in the secondary group (27.3%, 6/22) (χ2=4.539, P=0.033).Conclusions Compared with primary gastrointestinal NHLs, secondary gastrointestinal NHLs is more common having group B symptoms and colorectal involvement. MALT lymphoma is rare and H.pylori infection rate is lower than that of primary gastrointestinal lymphoma.

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备注/Memo

备注/Memo:
基金项目：科技部国家重点研发计划（2017YFC0109503）**通讯作者，Email：dingshigang222@163.com
更新日期/Last Update: 2019-04-09