[1]李高峰**,章硕.介入联合放射治疗与介入治疗原发性大/巨大肝癌的比较[J].中国微创外科杂志,2018,18(1):23-25.
　Li Gaofeng,Zhang Shuo..Comparison Between Interventioral Therapy Combined With Radiotherapy and Interventional Therapy for Primary Huge Liver Cancer[J].Chinese Journal of Minimally Invasive Surgery,2018,18(1):23-25.
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介入联合放射治疗与介入治疗原发性大/巨大肝癌的比较()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
18
期数:
2018年1期
页码:
23-25
栏目:
临床研究
出版日期:
2018-03-21

文章信息/Info

Title:
Comparison Between Interventioral Therapy Combined With Radiotherapy and Interventional Therapy for Primary Huge Liver Cancer
作者:
李高峰**; 章硕
株洲市中心医院肿瘤科，株洲412000
Author(s):
Li Gaofeng;  Zhang Shuo.
Department of Oncology, Zhuzhou Central Hospital, Zhuzhou 412000, China
关键词:
原发性肝癌; 放射治疗; 介入治疗
Keywords:
Primary liver cancer; Radiotherapy; Interventional therapy
文献标志码:
A
摘要:
目的探讨经肝动脉化疗栓塞（transcatheter arterial chemoembolization，TACE）联合放射治疗（放疗）治疗原发性大/巨大肝癌的疗效。方法2013年1月~2014年6月我科对30例原发性大/巨大肝癌行TACE联合三维适形或调强放疗，肿瘤放疗剂量达60 Gy/30次（治疗组），与同期35例原发性大/巨大肝癌行单纯TACE（对照组）进行比较。结果治疗组有效率63.3%（19/30），显著高于对照组37.1%（13/35）（χ2=4.433,P=0.035）。治疗组1、2、3年生存率分别是76.7％、53.3％和23.3％，对照组分别是62.9％、25.7％和11.4％，治疗组累积生存率显著高于对照组（χ2 =3.967,P=0.046）。治疗组二期手术切除率为26.7%(8/30)，显著高于对照组5.7%(2/35)（χ2=3.957,P=0047）。2组毒副作用可耐受。结论TACE联合放疗是原发性大/巨大肝癌的一种有效方法，毒副作用可耐受，可延长生存期。
Abstract:
ObjectiveTo evaluate the treatment efficiency of transcatheter arterial chemoembolization (TACE) combined with radiotherapy for the treatment of huge liver cancer.MethodsFrom January 2013 to June 2014, a total of 30 cases of huge liver cancer were treated with TACE and 3D conformal intensity modulated radiotherapy, with a total dose of over 60 Gy/30 times (treatment group). They were compared with another 35 cases treated with interventional therapy (control group).ResultsThe effective rate (CR+PR) of the treatment group was 63.3%(19/30), which was significantly higher than the control group ［371%（13/35）, χ2=4.433, P=0.035］. The survival rate of 1, 2, and 3 years were 76.7%, 53.3%, and 23.3% in the treatment group and 62.9%, 25.7%, and 11.4% in the control group. The cumulative survival rate was significantly higher in the treatment group than that in the control group (χ2=3.967, P=0.046). The two-stage surgical resection rate was 26.7%(8/30)in the treatment group, which was significantly higher than that in the control group ［5.7%(2/35), χ2=3.957, P=0.047］. The toxic and side effects were tolerable in both groups.ConclusionTACE combined with radiotherapy can significantly raise the effective rate and survival rate,and its toxic and side effects are tolerable.

参考文献/References:

[1]汤钊猷,主编.现代肿瘤学.上海:科技出版社，2000.748.
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备注/Memo

备注/Memo:
基金项目：湖南省株洲市株卫发【2017】18号，株科发【2015】33号**通讯作者，E-mail：ligaofeng1000@sina.com.cn
更新日期/Last Update: 2018-03-21