[1]冯彩霞① 郭红燕﹡ 孔东丽 贺豪杰 张坤 韩劲松 熊光武 闫霞② 孔为民②.宫颈绒毛管状腺癌9例临床分析[J].中国微创外科杂志,2016,16(09):807-811.
　Feng Caixia,Guo Hongyan*,Kong Dongli*,et al.Clinical Study of 9 Cases of Villoglandular Adenocarcinoma of Uterine Cervix[J].Chinese Journal of Minimally Invasive Surgery,2016,16(09):807-811.
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宫颈绒毛管状腺癌9例临床分析()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
16
期数:
2016年09期
页码:
807-811
栏目:
临床研究
出版日期:
2016-09-09

文章信息/Info

Title:
Clinical Study of 9 Cases of Villoglandular Adenocarcinoma of Uterine Cervix
作者:
冯彩霞① 郭红燕﹡ 孔东丽 贺豪杰 张坤 韩劲松 熊光武 闫霞② 孔为民②
（北京大学第三医院妇产科，北京100083）
Author(s):
Feng Caixia;  Guo Hongyan*;  Kong Dongli*;  et al.
*Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, China
关键词:
宫颈肿瘤; 宫颈绒毛管状腺癌; 肿瘤转移; 肿瘤复发
Keywords:
Uterine cervical neoplasms; Villoglandular adenocarcinoma; Neoplasm metastasis; Neoplasm recurrenceYoung
文献标志码:
A
摘要:
目的探讨宫颈绒毛管状腺癌(villoglandular adenocarcinoma，VGA)的临床及病理特征、处理方法及预后。方法回顾性分析2009年11月~2015年11月北京大学第三医院7例及北京妇产医院2例VGA患者的临床特征、病理结果、治疗方案以及随诊结局。年龄33～58岁，中位数43岁。主要症状为阴道排液(4例)或阴道不规则出血(3例)。国际妇产科联盟(FIGO)分期ⅠA2期1例，ⅠB1期5例，ⅡA2期1例，ⅡB期2例。1例ⅠA2期患者锥切后观察；5例ⅠB1期患者均无生育要求，行腹腔镜广泛性全子宫切除+双附件切除+盆腔淋巴结清扫±腹主动脉旁淋巴结清扫术，其中3例术后辅助放化疗；1例ⅡA2期行宫颈癌根治术；2例ⅡB期中1例新辅助同步放化疗后行双侧输尿管支架置入+腹腔镜次广泛子宫双附件切除术，另1例行腹腔镜双附件切除+盆腔及腹主动脉旁淋巴结清扫术，术后放化疗。结果7例行淋巴结清扫者中ⅡB期1例盆腔淋巴结浸润。8例卵巢切除中1例ⅡB期术中卵巢表面未见异常，术后病理双侧卵巢中分化腺癌。随访3~75个月，中位数27个月，无术后复发及死亡。结论与常见病理类型的宫颈癌相比，VGA发病相对年轻，肿瘤多外生型生长，淋巴结及卵巢转移率低，预后良好。但由于病例数相对少，且为回顾性分析，难以得出十分有说服力的结论。
Abstract:
ObjectiveTo explore the clinicopathologic features, management and prognosis of villoglandular adenocarcinoma (VGA) of uterine cervix. MethodsFrom November 2009 to November 2015, a total of 9 cases of VGA were reviewed retrospectively. Their median age was 43 (33-58) years old. The major symptoms were vaginal drainage (4 cases) and abnormal vaginal hemorrhage (3 cases). And the International Federation of Gynecology and Obstetrics (FIGO) stages were 1 case of ⅠA2, 5 cases of ⅡB1, 1 case of ⅡA2, and 2 cases of ⅡB. One patient at stage ⅠA2 was given observation after conization. Five patients at stage ⅠB1 underwent laparoscopic radical hysterectomy and bilateral salpingooophorectomy (BSO) plus pelvic lymphadenectomy, with three patients of postoperative chemotherapy. One patient at stage ⅡA2 underwent radical hysterectomy plus pelvic lymphadenectomy. One patient at stage ⅡB underwent radical hysterectomy with concurrent radiotherapy and chemotherapy, while another patient at stage ⅡB underwent radiotherapy and concurrent chemotherapy after BSO and pelvic lymphadenectomy. ResultsOut of the 7 patients receiving lymphadenectomy, one stage ⅡB patient had positive pelvic lymph nodes. Out of the 8 patients receiving BSO, one stage ⅡB patient had moderately differentiated adenocarcinoma in ovarian. The median followup period was 27 months (range, 3-75 months). All the patients survived without recurrence. ConclusionsVGA mainly affects younger women and the prognosis is generally fair with a lower rate of ovarian metastasis and lymphatic metastasis as compared to common forms of cervical cancer. Due to a limited sample size and retrospective clinical data study, multicenter prospective studies are warranted for a better understanding of this disease.

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备注/Memo

备注/Memo:
﹡通讯作者,Email：bysyghy@163.com①（陕西省榆林市第一医院妇产科一病区，榆林719000）②（首都医科大学附属北京妇产医院肿瘤科，北京100026）
更新日期/Last Update: 2016-12-09