[1]楚蔚昕 葛伟平 张萍 陈龙* 刘艳生 杨志豪①.腹腔镜子宫腺肌病病灶切除联合GnRH-a治疗的对比研究[J].中国微创外科杂志,2015,15(10):897-900.
　Chu Weixin,Ge Weiping,Zhang Ping,et al.Comparative Study of Laparoscopic Adenomyomectomy Combined with GnRH-a Treatment for Uterine Adenomyosis[J].Chinese Journal of Minimally Invasive Surgery,2015,15(10):897-900.
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腹腔镜子宫腺肌病病灶切除联合GnRH-a治疗的对比研究()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
15
期数:
2015年10期
页码:
897-900
栏目:
临床论著
出版日期:
2015-10-20

文章信息/Info

Title:
Comparative Study of Laparoscopic Adenomyomectomy Combined with GnRH-a Treatment for Uterine Adenomyosis
作者:
楚蔚昕 葛伟平 张萍 陈龙* 刘艳生 杨志豪①
（山东省青岛市市立医院妇科，青岛266011）
Author(s):
Chu Weixin;  Ge Weiping;  Zhang Ping;  et al.
Department of Gynecology, Qingdao Municipal Hospital, Qingdao 266011, China
关键词:
子宫腺肌病; 腹腔镜; 促性腺激素释放激素激动剂
Keywords:
Uterine adenomyosis; Laparoscopy; Gonadotropin-releasing hormone agonist
分类号:
R713.4
文献标志码:
A
摘要:
目的探讨腹腔镜子宫腺肌病病灶切除术联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫腺肌病的疗效。方法回顾性分析2009年1月~2013年5月我院79例行腹腔镜子宫腺肌病病灶切除术患者的临床资料，其中手术联合药物组（A组）42例，术后第3天皮下注射亮丙瑞林6个疗程（28天一次），单纯手术组（B组）37例，比较2组治疗后痛经、月经量、子宫体积的变化。结果2组治疗后痛经分级降低（F=342.967，P=0.000)，月经量评分降低（F=135.743，P=0.000），子宫体积缩小（F=393.341，P=0.000）。与B组相比，A组痛经分级和月经量评分降低明显（F=14.274，P=0000，F=18.222，P=0.000），子宫体积明显缩小（F=30.692，P=0.000）。随访12~64个月，（30.3±10.3）月，A和B组的有效率分别为810%（34/42）、62.2%（21/37）（log-rank χ2=4.915，P=0.027)。结论腹腔镜子宫腺肌病病灶切除联合GnRH-a治疗能更有效地控制患者的临床症状，减少复发。
Abstract:
ObjectiveTo discuss the effect of laparoscopic adenomyomectomy combined with gonadotropin-releasing hormone agonist (GnRH-a) administration in the treatment of uterine adenomyosis. MethodsClinical data of 79 patients with uterine adenomyosis from January 2009 to May 2013 were collected. The patients of group A (42 cases) were given triptorelin for 6 courses after laparoscopic adenomyomectomy, whereas the patients of group B (37 cases) underwent laparoscopic adenomyomectomy alone. The dysmenorrhea, the menstrual amount and the uterine volume were analyzed.ResultsAfter treatment, the dysmenorrhea grade, the menstrual volume score and the uterine volume of the two groups were all significantly decreased (F=342.967, P=0.000; F=135.743, P=0.000; F=393.341, P=0.000). The dysmenorrhea grade and menstrual volume score in the group A were statistically lower than those in the group B (F=14.274, P=0.000; F=18.222, P=0.000). The uterine volume in the group A was smaller than that in the group B (F=30.692, P=0.000). The effect rates of group A and group B during follow-up were 81.0%(34/42) and 62.2%(21/37), respectively (χ2=4.915, P=0.027).ConclusionsLaparoscopic adenomyomectomy can effectively used for uterine adenomyosis. Combined with GnRH-a after adenomyomectomy, the method is more effective in controlling symptoms and reducing disease recurrence.

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备注/Memo

备注/Memo:
*通讯作者，E-mail：chenlong6517@vip.sina.com①（四川大学生命科学院生物科学基地班，成都610065）
更新日期/Last Update: 2016-02-03