[1]肖震宇* 杨藩 童兵 黄志勇.牛磺熊去氧胆酸预防肝胆管结石术后复发的随机对照研究[J].中国微创外科杂志,2015,15(10):891-893.
　Xiao Zhenyu,Yang Fan,Tong Bing,et al.A Randomized Controlled Study on Tauroursodeoxycholic Acid for the Prevention of Postoperative Relapse of Hepatic Calculus[J].Chinese Journal of Minimally Invasive Surgery,2015,15(10):891-893.
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牛磺熊去氧胆酸预防肝胆管结石术后复发的随机对照研究()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
15
期数:
2015年10期
页码:
891-893
栏目:
临床论著
出版日期:
2015-10-20

文章信息/Info

Title:
A Randomized Controlled Study on Tauroursodeoxycholic Acid for the Prevention of Postoperative Relapse of Hepatic Calculus
作者:
肖震宇* 杨藩 童兵 黄志勇
（华中科技大学同济医学院附属同济医院普外科，武汉430030）
Author(s):
Xiao Zhenyu;  Yang Fan;  Tong Bing;  et al.
Department of General Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
关键词:
肝胆管结石; 术后复发; 牛磺熊去氧胆酸
Keywords:
Hepatic calculus; Relapse after surgery; Tauroursodeoxycholic acid
分类号:
R657.4
文献标志码:
A
摘要:
目的探讨肝胆管结石手术后口服牛磺熊去氧胆酸（tauroursodeoxycholic acid ，TUDCA）预防结石复发的有效性及临床价值。方法我院2010年1月~2012年1月90例手术治疗的肝胆管结石患者，术后采用完全随机化分组法分为2组，每组45例。TUDCA组口服TUDCA（500 mg，每天1次，每月连续服用5天后停药25天，治疗期为2年），对照组不服药。2组随访方法相同，比较术后2年肝胆管结石复发率和因结石复发的再手术率。结果术后2年TUDCA组胆管结石复发率为6.7%（3/45），对照组为26.7%（12/45）（χ2=6.480，P=0.011）；TUDCA组再手术率为2.2%（1/45），对照组为20.0%（9/45）（χ2=7.200，P=0.007）。结论肝胆管结石手术后口服牛磺熊去氧胆酸能够有效预防胆管结石的复发。
Abstract:
ObjectiveTo study the efficacy and application value of tauroursodeoxycholic acid(TUDCA) for the prevention of postoperative relapse of hepatic calculus.MethodsA total of 90 hepatic calculus patients surgically treated in our hospital were divided into two groups randomly, with 45 patients in each group. The patients in the therapeutic group were given TUDCA after surgery for two years (500 mg/day for 5 days every month), whereas the patients in the control group received the same nursing and diet therapies without medication. Both groups were followed up for 2 years. The statistics of the relapse rate of hepatic calculus and reoperation rate were conducted, and the comparison between the two groups was performed.ResultsThere was significant difference between the therapeutic group and the control group at two years after surgery in terms of the relapse rate of hepatic calculus ［6.7% (3/45) vs. 26.7% (12/45), χ2=6.480, P=0.011］ and reoperation rate ［2.2% (1/45) vs. 20.0% (9/45), χ2=7200, P=0.007］.ConclusionThe application of TUDCA in patients after hepatic calculus surgery can prevent the relapse of hepatic stones.　

参考文献/References:

[1]何宇，别平.肝胆管结石外科治疗难点与策略.中华普外科手术学杂志，2012,6(4)：351-355.
[2]Qiao X,Ye M,Pan DL,et al.Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry.J Chromatogr A,2011,1218(1):107-117.
[3]段勇，胡芫.肝胆道结石二次手术60例的临床分析.齐齐哈尔医学院学报，2011,10(1)：51.
[4]傅贤波,林三仁,范竹萍,等.牛磺熊去氧胆酸溶解胆囊胆固醇结石有效性和安全性——随机、双盲、安慰剂对照、多中心临床研究.中国微创外科杂志,2007,7(12)：1159-1163.
[5]刘付宝,耿小平.肝内胆管结石的病因学研究.肝胆外科杂志，2014,22(3):227-230.
[6]Tazuma S,Kanno K,Sugiyama A,et al.Nutritional factors (nutritional aspects) in biliary disorders: bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction.J Gastroenterol Hepatol,2013,12(4):103-107.
[7]Vítek L,Carey MC.New pathophysiological concepts underlying pathogenesis of pigment gallstones.Clin Res Hepatol Gastroenterol,2012,36(2):122-129.
[8]Henkel AS,Gooijert KE,Havinga R,et al.Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.Am J Physiol Gastrointest Liver Physiol,2013,304(2):221-226.
[9]Gallo V,De Micheli AG,Chiandussi L.Tauroursodeoxycholic acid vs. ursodeoxycholic acid in the dissolution of biliary calculi.Results of a single blind study.Clin Ter,1993,143(5):421-428.

备注/Memo

备注/Memo:
*通讯作者，E-mail：xiaozhenyu58@163.com
更新日期/Last Update: 2016-02-03