参考文献/References:
[1]Bedford PD.Adverse cerebral effects of anaesthesia on old people.Lancet,1955,269(6884):259-263.
[2]Moller JT,Cluitmans P,Rasmussen LS,et al.Longterm postoperative cognitive dysfunction in the elderly ISPOCD1 study.ISPOCD investigators.International Study of PostOperative Cognitive Dysfunction.Lancet,1998,351(9106):857-861.
[3]Krenk L,Rasmussen LS,Kehlet H.New insights into the pathophysiology of postoperative cognitive dysfunction.Acta Anaesthesiol Scand,2010,54(8):951-956.
[4]Monk TG,Price CC.Postoperative cognitive disorders.Curr Opin Crit Care,2011,17(4):376-381.
[5]Silbert BS,Evered LA,Scott DA.Incidence of postoperative cognitive dysfunction after general or spinal anaesthesia for extracorporeal shock wave lithotripsy.Br J Anaesth,2014,113(5):784-791.
[6]van Harten AE,Scheeren TW,Absalom AR.A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia.Anaesthesia,2012,67(3):280-293.
[7]HolroydLeduc JM,Khandwala F,Sink KM.How can delirium best be prevented and managed in older patients in hospital?CMAJ,2010,182(5):465-470.
[8]Rundshagen I.Postoperative cognitive dysfunction.Dtsch Arztebl Int,2014,111(8):119-125.
[9]Scott DA,Evered LA,Silbert BS.Cardiac surgery, the brain, and inflammation.J Extra Corpor Technol,2014,46(1):15-22.
[10]Mason SE, NoelStorr A,Ritchie CW.The impact of general and regional anesthesia on the incidence of postoperative cognitive dysfunction and postoperative delirium: a systematic review with metaanalysis.J Alzheimers Dis,2010,22 Suppl 3:67-79.
[11]Kumar NT,Liestol K,Loberg EM,et al.Apolipoprotein E allelotype is associated with neuropathological findings in Alzheimer’s disease.Virchows Arch,2015,Apr 22.[Epub ahead of print]
[12]Harwood DG,Barker WW,Ownby RL,et al.Apolipoprotein E polymorphism and age of onset for Alzheimer’s disease in a biethnic sample.Int Psychogeriatr,2004,16(3):317-326.
[13]Cai Y,Hu H,Liu P,et al.Association between the apolipoprotein E4 and postoperative cognitive dysfunction in elderly patients undergoing intravenous anesthesia and inhalation anesthesia.Anesthesiology,2012,116(1):84-93.
[14]Cao L,Wang K,Gu T,et al.Association between APOE epsilon 4 allele and postoperative cognitive dysfunction:a metaanalysis.Int J Neurosci,2014,124(7):478-485.
[15]Kutlu MG,Gould TJ.Nicotinic receptors,memory,and hippocampus.Curr Top Behav Neurosci,2015,23:137-163.
[16]Hahn B.Nicotinic receptors and attention.Curr Top Behav Neurosci,2015,23:103-135.
[17]Jensen MM,Arvaniti M,Mikkelsen JD,et al.Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer’s disease.Neurobiol Aging,2015,36(4):1629-1638.
[18]Kar S,Slowikowski SP,Westaway D,et al.Interactions between betaamyloid and central cholinergic neurons: implications for Alzheimer’s disease.J Psychiatry Neurosci,2004,29(6):427-441.
[19]Xie Z,Dong Y,Maeda U,et al.The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels.Anesthesiology,2006,104(5):988-994.
[20]Xie Z,Culley DJ,Dong Y,et al.The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid betaprotein level in vivo.Ann Neurol,2008,64(6):618-627.
[21]Shoair OA,Grasso IM,Lahaye LA,et al.Incidence and risk factors for postoperative cognitive dysfunction in older adults undergoing major noncardiac surgery:a prospective study.J Anaesthesiol Clin Pharmacol,2015,31(1):30-36.
[22]Ruxton K,Woodman RJ,Mangoni AA.Drugs with anticholinergic effects and cognitive impairment,falls and allcause mortality in older adults:a systematic review and metaanalysis.Br J Clin Pharmacol,2015,Mar 2.[Epub ahead of print]
[23]田小生,周婷,崔德华,等.术后认知功能障碍.神经疾病与精神卫生,2012,12(1):1-5.
[24]Rasmussen LS,Moller JT.Central nervous system dysfunction after anesthesia in the geriatric patient.Anesthesiol Clin North America,2000,18(1):59-70.
[25]Riedel G,Platt B,Micheau J.Glutamate receptor function in learning and memory.Behav Brain Res,2003,140(1-2):1-47.
[26]Rezvani AH.Involvement of the NMDA System in Learning and Memory.Animal Models of Cognitive Impairment.Boca Raton: CRC Press,2006.Chapter 4.
[27]Wang H,Peng R,Zhao L,et al.The relationship between NMDA receptors and microwaveinduced learning and memory impairment:a longterm observation on Wistar rats.Int J Radiat Biol,2015,91(3):262-269.
[28]Guidi M,Kumar A,Foster TC.Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.J Neurosci,2015,35(9):3966-3977.
[29]Liu DS,Pan XD,Zhang J,et al.APOE4 enhances agedependent decline in cognitive function by downregulating an NMDA receptor pathway in EFADTg mice.Mol Neurodegener,2015,10(1):7.
[30]Abdulrahman H,Fletcher PC,Bullmore E,et al.Dopamine and memory dedifferentiation in aging.Neuroimage,2015,Mar 21.[Epub ahead of print]
[31]Reeves S,Mehta M,Howard R,et al.The dopaminergic basis of cognitive and motor performance in Alzheimer’s disease.Neurobiol Dis,2010,37(2):477-482.
[32]Liu X,Ye K,Weinshenker D.Norepinephrine protects against amyloidbeta toxicity via TrkB.J Alzheimers Dis,2015,44(1):251-260.
[33]Mei Y,Jiang C,Wan Y,et al.Agingassociated formaldehydeinduced norepinephrine deficiency contributes to agerelated memory decline.Aging Cell,2015,Apr 11.[Epub ahead of print]
[34]Sudheimer KD,O’Hara R,Spiegel D,et al.Cortisol,cytokines,and hippocampal volume interactions in the elderly.Front Aging Neurosci,2014,6:153.
[35]Terrando N,Eriksson LI,Ryu JK,et al.Resolving postoperative neuroinflammation and cognitive decline.Ann Neurol,2011,70(6):986-995.
[36]Fung A,Vizcaychipi M,Lloyd D,et al.Central nervous system inflammation in disease related conditions: mechanistic prospects.Brain Res,2012,1446:144-155.
[37]Cumiskey D,Curran BP,Herron CE,et al.A role for inflammatory mediators in the IL18 mediated attenuation of LTP in the rat dentate gyrus.Neuropharmacology,2007,52(8):1616-1623.
[38]Butler MP,O’Connor JJ,Moynagh PN.Dissection of tumornecrosis factoralpha inhibition of longterm potentiation (LTP) reveals a p38 mitogenactivated protein kinasedependent mechanism which maps to earlybut not latephase LTP.Neuroscience,2004,124(2):319-326.
[39]Belarbi K,Jopson T,Tweedie D,et al.TNFalpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation.J Neuroinflammation,2012,9:23.
[40]Cibelli M,Fidalgo AR,Terrando N,et al.Role of interleukin1beta in postoperative cognitive dysfunction.Ann Neurol,2010,68(3):360-368.
[41]Wan Y,Xu J,Ma D,et al.Postoperative impairment of cognitive function in rats: a possible role for cytokinemediated inflammation in the hippocampus.Anesthesiology,2007,106(3):436-443.
[42]Mishra A,Kim HJ,Shin AH,et al.Synapse loss induced by interleukin1beta requires pre and postsynaptic mechanisms.J Neuroimmune Pharmacol,2012,7(3):571-578.
[43]Parolari A,Camera M,Alamanni F,et al.Systemic inflammation after onpump and offpump coronary bypass surgery: a onemonth followup.Ann Thorac Surg,2007,84(3):823-828.
[44]Ramlawi B,Rudolph JL,Mieno S,et al.CReactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery.Surgery,2006,140(2):221-226.
[45]Li YC,Xi CH,An YF,et al.Perioperative inflammatory response and protein S100beta concentrationsrelationship with postoperative cognitive dysfunction in elderly patients.Acta Anaesthesiol Scand,2012,56(5):595-600.
[46]Cao XZ, Ma H,Wang JK, et al.Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats.Prog Neuropsychopharmacol Biol Psychiatry,2010,34(8):1426-1432.
[47]Wu X,Lu Y,Dong Y,et al.The inhalation anesthetic isoflurane increases levels of proinflammatory TNFalpha, IL6, and IL1beta.Neurobiol Aging,2010,33(7):1364-1378.
[48]Arfi A,Richard M,Gandolphe C,et al.Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of longterm aspirin treatment.Mol Genet Metab,2011,103(1):18-25.
[49]Wu Y,Zhai H,Wang Y,et al.Aspirintriggered lipoxin A(4) attenuates lipopolysaccharideinduced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase.Neurochem Res,2012,37(8):1690-1696.
[50]Jaturapatporn D,Isaac MG,Mccleery J,et al.Aspirin,steroidal and nonsteroidal antiinflammatory drugs for the treatment of Alzheimer’s disease.Cochrane Database Syst Rev,2012,2:D6378.
[51]Lee M,Sparatore A,Del SP,et al.Hydrogen sulfidereleasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation.Glia,2010,58(1):103-113.
[52]Vizcaychipi MP,Watts HR,O’Dea KP,et al.The therapeutic potential of atorvastatin in a mouse model of postoperative cognitive decline.Ann Surg,2014,259(6):1235-1244.
[53]Katznelson R,Djaiani GN,Borger MA,et al.Preoperative use of statins is associated with reduced early delirium rates after cardiac surgery.Anesthesiology,2009,110(1):67-73