[1]邵建国 侯飓* 宋飞 赵谦 郭环宇 黄伟 韩增箎.上尿路胱氨酸结石诊治22例报告[J].中国微创外科杂志,2015,15(7):622-627.
 Shao Jianguo,Hou Ju,Song Fei,et al.Diagnosis and Treatment of Upper Urinary Cystine Calculi: a Report of 22 Cases[J].Chinese Journal of Minimally Invasive Surgery,2015,15(7):622-627.
点击复制

上尿路胱氨酸结石诊治22例报告()
分享到:

《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
15
期数:
2015年7期
页码:
622-627
栏目:
临床研究
出版日期:
2015-07-20

文章信息/Info

Title:
Diagnosis and Treatment of Upper Urinary Cystine Calculi: a Report of 22 Cases
作者:
邵建国 侯飓* 宋飞 赵谦 郭环宇 黄伟 韩增箎
(山东中医药大学第二附属医院泌尿外科,济南250001)
Author(s):
Shao Jianguo Hou Ju Song Fei et al.
Department of Urology, Second Affiliated Hospital of Shandong University of Chinese Medicine, Jinan 250001,China
关键词:
胱氨酸结石经皮肾镜碎石清石术体外冲击波碎石溶石
Keywords:
Cystine calculiPercutaneous nephrolithotomy lithotripsy(PCNL)Extracorporeal shock wave lithotripsyLitholytic therapy
分类号:
R692.4
文献标志码:
A
摘要:
目的探讨上尿路胱氨酸结石的诊治方法。方法2005年3月~2013年3月治疗22例上尿路胱氨酸结石,其中肾脏铸型结石10例,肾多发结石9例,肾多发结石合并输尿管结石3例,8例仅行经皮肾镜碎石清石术(percutaneous nephrolithotomy lithotripsy,PCNL),3例行PCNL+输尿管镜碎石术(ureteroscopic lithotripsy,URL),9例行PCNL+体外冲击波碎石(extracorporeal shock wave lithotripsy,ESWL)+经肾造瘘管肾盂内灌注氨基丁三醇E(THAME)溶石,2例仅行ESWL。结果17例结石完全清除,5例结石残留,清石清除率77.2%(17/22),无严重并发症发生。22例随访6~36个月,平均24个月,3例结石复发,5例结石残留中4例结石体积增大。结论PCNL联合ESWL及药物溶石治疗上尿路复杂胱氨酸结石,结石清除效果满意。
Abstract:
ObjectiveTo evaluate diagnosis and treatment of upper urinary cystine calculi.MethodsWe retrospectively analyzed clinical data of 22 patients with upper urinary cystine calculi from March 2005 to March 2013. There were 10 cases of staghorm calculi, 9 cases of multiple calculi, and 3 cases of upper ureteral calculi combined with multiple renal calculi. Eight patients underwent PCNL only, 3 patients underwent PCNL+URL, 9 patients underwent PCNL+ESWL+litholytic therapy with THAME perfusing into renal pelvis through nephrostomy tubes, and 2 patients underwent ESWL only.ResultsThe calculi completely disappeared in 17 cases (77.2%), while residual stones occurred in 5 cases, the clearance rate being 77.2% (17/22). No major complications were noted. All the 22 patients were followed up for 6-36 months, with an average of 24 months. Recurrence of calculi was found in 3 cases, and calculi enlarged with different degree in 4 out of 5 cases of residual stones.ConclusionCombination of PCNL, ESWL, and litholytic therapy has good effects in the treatment of complicated renal cystine calculi.

参考文献/References:

[1]陈志强,曾令启,叶章群,等.氨基丁三醇E液局部灌注治疗输尿管尿酸结石(附14例报告).中华泌尿外科杂志,2004,25(6):401-403.
[2]Sayer JA. The genetics of nephrolitiasis. Nephron Exp Nephrol,2008,111(2):37-43.
[3]Stoller ML,Bruce JE, Bruce CA, et al. Linkage of type Ⅱ and type Ⅲ cystinuria to 19q131: codominant inheritance of two cystinuric alleles at 19q13.1 produces an extreme stoneforming phenotype. Am J Med Genet,1999,86(2):134-139.
[4]张学斌,李汉忠,孙昊,等.双源CT在体内预测尿路结石成分的临床应用价值.临床泌尿外科杂志,2014,29(2):93-96.
[5]Thomas C,Heuschmid M, Schilling L, et al. Urinary calculi composed of uric acid, cystine, and mineral salts: differentiation with dualenergy CT at a radiation dose comparable to that of intravenous pyelography. Radiology,2010,257(2):402-409.
[6]Ahmed K, Khan MS, Thomas K, et al. Management of cystinuric patients: an observational, retrospective, singlecentre analysis. Urol Int,2008,80(2):141-144.
[7]俞蔚文,张大宏,何翔,等.联合不同口径多通道经皮肾镜取石术治疗复杂性肾结石.中国微创外科杂志,2013,13(9):820-823.
[8]Heimbach D, Jacobs D, Muller SC, et al. Improving cystine stone therapy: an in vitro study of dissolution. Urology,2000,55(1):17-21.
[9]Onal B,Dogan C,Citgez S,et al. Percutaneous nephrolithotomy in children with cystine stone: longterm outcomes from a single institution. Urology,2013,190(1):234-237.

备注/Memo

备注/Memo:
*通讯作者,Email:houdg2005@aliyun.com
更新日期/Last Update: 2016-01-04