[1]李楠＊ 王贺玲 梁晓平 杨明.SEPTIN 9在胃癌组织中的表达及临床意义[J].中国微创外科杂志,2014,14(12):1125-1127.
　Li Nan,Wang Heling,Liang Xiaoping,et al.Expression of SEPTIN 9 in Gastric Cancer Tissues and Its Clinical Significance[J].Chinese Journal of Minimally Invasive Surgery,2014,14(12):1125-1127.
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SEPTIN 9在胃癌组织中的表达及临床意义()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
14
期数:
2014年12期
页码:
1125-1127
栏目:
基础研究
出版日期:
2014-12-20

文章信息/Info

Title:
Expression of SEPTIN 9 in Gastric Cancer Tissues and Its Clinical Significance
作者:
李楠＊ 王贺玲 梁晓平 杨明
沈阳市第一人民医院消化内科，沈阳110041
Author(s):
Li Nan;  Wang Heling;  Liang Xiaoping;  et al.
Department of Digestive Medicine, First People’s Hospital, Shenyang 110041, China
关键词:
SEPTIN 9; 胃癌; 免疫组织化学
Keywords:
SEPTIN 9; Gastric cancer; Immunohistochemistry
分类号:
R735.204
文献标志码:
A
摘要:
目的探讨SEPTIN 9在胃癌组织中的表达及临床意义。方法从我院内镜室收集102例胃癌组织及其癌旁组织标本，通过组织微阵列和免疫组织化学染色方法检测胃癌及其癌旁组织中SEPTIN 9蛋白表达水平，并结合相应的病理资料，分析SEPTIN 9与胃癌组织分化程度的关系。 结果在102例胃癌组织中，84例（82.4%）SEPTIN 9表达阳性；在102例癌旁组织中，35例（34.3%）表达阳性,胃癌组织中SEPTIN 9的阳性表达率显著高于癌旁组织（χ2=48.424，P=0.000）。在58例高中分化胃癌组织中，23例（39.6%）SEPTIN 9高表达，在44例低分化胃癌组织中，40例（90.9%）SEPTIN 9高表达，二者高表达率有显著性差异（χ2=27.931，P=0.000）。结论SEPTIN 9在胃癌组织中高达，且与胃癌的分化程度有关。
Abstract:
ObjectiveTo explore the clinical significance of SEPTIN 9 expression in gastric cancer (GC) tissues.MethodsA total of 102 GC tissues and 102 paracancer tissues from surgical resected specimen were included in this study. Tissue microarray and immunohistochemistry (IHC) were used to detect SEPTIN 9 protein expression in the tissues. The clinical pathological data were collected for reviewing the relation between SEPTIN 9 expression and tissue differentiation.ResultsThe SEPTIN 9 protein was mainly expressed in the cytoplasm. The expression rate in GC tissues was significantly higher than that in paracancer normal tissues (82.4% vs. 34.3%, χ2=48.424, P=0.000). The SEPTIN 9 protein overexpression rate in lowly differentiated GC tissues was significantly higher than that in highly and moderately differentiated GC tissues (90.9% vs. 39.6%, χ2=27.931, P=0.000).ConclusionsThe level of SEPTIN 9 protein is higher in GC tissues than that in paracancer normal tissues. The expression of SEPTIN 9 protein is associated with the degree of cancer differentiation.

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备注/Memo

备注/Memo:
＊通讯作者，Email:baichunxin413@163.com
更新日期/Last Update: 2014-12-20