[1]阚雄文,张松柏,谢雄伟,等.腹腔镜治疗小儿穿孔性阑尾炎对血清C反应蛋白和降钙素原的影响[J].中国微创外科杂志,2013,13(6):496-499.
　Kan Xiongwen,Zhang Songbai,Xie Xiongwei,et al.Effect of Laparoscopic Surgery of Perforative Appendicitis on the Serum Level of CRP and PCT of Children[J].Chinese Journal of Minimally Invasive Surgery,2013,13(6):496-499.
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腹腔镜治疗小儿穿孔性阑尾炎对血清C反应蛋白和降钙素原的影响()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
13
期数:
2013年6期
页码:
496-499
栏目:
出版日期:
2013-06-20

文章信息/Info

Title:
Effect of Laparoscopic Surgery of Perforative Appendicitis on the Serum Level of CRP and PCT of Children
作者:
阚雄文; 张松柏; 谢雄伟; 何方; 汤绍涛＊＊
湖北省荆门市第一人民医院普外科，荆门448000
Author(s):
Kan Xiongwen;  Zhang Songbai;  Xie Xiongwei; et al.
Department of General Surgery，The First People’s Hospital of Jingmen，Jingmen 448000，China
关键词:
穿孔性阑尾炎; 开腹阑尾切除术; 腹腔镜阑尾切除术; C反应蛋白; 降钙素原
Keywords:
Perforative appendicitis; Open appendectomy; Laparoscopic appendectomy; Creactive protein; Procalcitonin
分类号:
R726.1
文献标志码:
A
摘要:
目的比较腹腔镜与开腹手术治疗小儿穿孔性阑尾炎手术前后血清C反应蛋白(Creactive protein,CRP)和降钙素原(procalcitonin,PCT)的变化。方法采用前瞻性对照研究方法，将2010年6月~2012年10月临床诊断为穿孔性阑尾炎的78例患儿按家属意愿分为开放组（38例）和腹腔镜组（40例）。分别于术前0.5 h、术后24 h及48 h采外周静脉血，分别用ELISA法和胶体免疫结合法测定血清CRP和PCT。结果2组血清CRP和PCT术前差异无显著性（P>0.05）;术后24 h较术前均明显升高（P＜0.05），开放组CRP升高更明显（P=0.000）;术后48 h腹腔镜组PCT已恢复至术前水平（P>005），腹腔镜组CRP和开放组CRP、PCT仍高于术前（P＜0.05），且开放组明显高于腹腔镜组（P=0.000）。结论与开放手术相比，腹腔镜治疗小儿穿孔性阑尾炎引起CRP、PCT的变化较小。
Abstract:
ObjectiveTo explore the changes of CRP and PTC levels after laparoscopic or open appendectomy in children who had perforative appendicitis. MethodsA prospective casecontrol study was performed. Seventyeight children who were diagnosed as perforative appendicitis between June 2010 and October 2012 were assigned into the open appendectomy group (OA group) and laparoscopic appendectomy group (LA group) respectively at patients’ or their parents’ will. OA group and LA group included 38 and 40 cases respectively. The blood samples of all cases were collected half an hour before, 24 h and 48 h after the operation respectively. ELISA and immunochromatography assays were used to detect the levels of CRP and PCT respectively.ResultsThere was no significant difference between LA group and OA group in the preoperative levels of CRP and PCT（P>0.05）. Compared to preoperative levles, the levels of CRP and PCT were significantly increased 24 h after surgery in both groups （P＜0.05）with the levels of CRP in OA group being significantly higher than those in LA group（P=0.000）. The levels of PCT in LA group 48 h after operation returned to preoperative levels（P＞0.05）while the levels of CRP in LA group and the levels of CRP, PCT in OA group remained significantly higher than preoperative levels（P＜0.05）. Moreover, the levels of CRP and PCT in OA group 48 h after operation were significantly higher than those in LA group（P=0.000）.ConclusionCompared with open surgery, the changes of CRP and PCT after laparoscopic surgery were minor.

参考文献/References:

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备注/Memo

备注/Memo:
＊基金项目：湖北省卫生厅科研基金指导性项目（JX4C36）,＊＊通讯作者
更新日期/Last Update: 2014-01-08