[1]褚剑,韩冰,尹东涛,等.机器人胸腺扩大切除术在老年重症肌无力患者中的应用[J].中国微创外科杂志,2013,13(1):9-28.
 Chu Jian,Han Bing,Ying Dongtao,et al.Roboticassisted Extended Thymectomy for Myasthenia Gravis in Elderly Patients[J].Chinese Journal of Minimally Invasive Surgery,2013,13(1):9-28.
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机器人胸腺扩大切除术在老年重症肌无力患者中的应用()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
13
期数:
2013年1期
页码:
9-28
栏目:
新技术新方法
出版日期:
2013-01-20

文章信息/Info

Title:
Roboticassisted Extended Thymectomy for Myasthenia Gravis in Elderly Patients
作者:
褚剑韩冰尹东涛陈秀崔琦马孟琦刘娜隋波①
第二炮兵总医院心胸外科,北京100088
Author(s):
Chu Jian Han Bing Ying Dongtao et al.
Department of Thoracic and Cardiovascular Surgery, Second General Hospital of PLA Artillery, Beijing 100088, China
关键词:
达芬奇S机器人胸腺切除术老年患者重症肌无力
Keywords:
Da vinci robotic surgeryThymectomyAged patientsMyasthenia gravis
分类号:
R655;R746.1
文献标志码:
B
摘要:
目的评价达芬奇S(da Vinci S)机器人胸腺扩大切除术在老年重症肌无力患者中的应用价值。方法2009年5月~2011年12月,使用da Vinci S机器人手术系统完成9例老年重症肌无力胸腺及胸腺瘤切除并进行胸腺周围脂肪组织清扫术。全身麻醉下双腔气管插管,仰卧位,一侧胸部垫高30°,术侧胸壁腋前线第5肋间皮肤切开1.5 cm,置入trocar作为观察孔,左右侧各约10 cm的距离(在腋前线第3肋间和锁骨中线第6肋间)置入左右机械手臂trocar,在腋中线第7肋间置入trocar作为辅助操作孔,连接机械手臂。人工气胸压力6~12 mm Hg。胸腺及周围脂肪组织置入一次性取物袋,经辅助操作孔取出。结果9例均手术成功,无中转开胸。麻醉时间平均180 min(60~210 min),机器人手术时间平均60 min(30~110 min),术中出血量平均100 ml(30~200 ml)。无手术输血,住ICU时间平均1 d(1~3 d)。9例随访5~32个月,平均12个月,DeFilippi分级1级2例,2级2例,3例5例,有效率100%。结论选择合适的老年患者,使用da Vinci S机器人手术系统行胸腺扩大切除术安全可行,效果确切。
Abstract:
ObjectiveTo evaluate the efficacy of roboticassisted extended thymectomy for myasthenia gravis in elderly patients. MethodsFrom May 2009 to December 2011, 9 elderly patients with myasthenia gravis, including 4 cases of thymoma, received extended thymectomy by using Da Vinci S surgical system with a doublelumen endobronchial intubation under general anesthesia. All the patients were set at a supine position with one side of the chest rising up by 30°. An 1.5cm incision was made on the anterior axillary line, at the fifth intercostal space so that to insert a trocar as a observation hole. And then on the anterior axillary line, at the third intercostal space, and on the midclavicular line, at the sixth intercostal space, two incisions were made (both were 10 cm away from the observation hole) to introduce the left and fight mechanical arm. Finally, a fourth trocar was placed through an incision on the midaxillary line at the seventh intercostal space, as an assistant operation hole. Artificial pneumothorax was established with a pressure set at 6-12 mm Hg. The thymus and surrounding fat tissues were all removed via the assistant operation hole. ResultsThe procedure was completed successfully without conversion to open surgery. The mean anesthesia time was 180 min (ranged from 60 to 210 min), and the mean time for roboticassisted procedure was 60 min (ranged from 30 to 110 min). The mean intraoperative blood loss was 100 ml (ranged from 30 to 200 ml),and no patient received blood transfusion. The mean ICU stay of the cases ranged from 1 to 3 days (mean, 1 day).Nine patients were followed up for 5 to 32 months with a mean of 12 months.According to DeFilippi standards,two patients got grade one,two grade two,three grade three,and the effective rate was 100%. ConclusionRoboticassited extended thymectomy is effective and safe for selected elderly patients.

参考文献/References:

[1]王伟,张临友,冀成山,等.胸腔镜胸腺扩大切除术治疗重症肌无力114例.哈尔滨医科大学学报,2011,45:188-189.
[2]Tomulescu V, Sgarbura O, Stanescu C, et al. Tenyear results of thoracoscopic unilateral extended thymectomy performed in nonthymomatous myasthenia gravis. Ann Surg,2011,254:761-765.
[3]Rückert JC, Swierzy M, Ismail M. Comparison of robotic and nonrobotic thoracoscopic thymectomy: a cohort study. J Thorac Cardiovasc Surg,2011,141:673-677.
[4]赵桂彬,崔键,郭庆凤,等.电视胸腔镜手术治疗非胸腺瘤重症肌无力的中期疗效和生活质量.中国微创外科杂志,2010,10:1088-1090.
[5]Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol,2010,17:893-902.
[6]Kumar N, Verma AK, Mishra A, et al. Factors predicting surgical outcome of thymectomy in myasthenia gravis: A 16year experience. Ann Indian Acad Neurol,2011, 14:267-271.
[7]Kim JY, Park KD, Richman DP. Treatment of myasthenia gravis based on its immunopathogenesis. J Clin Neurol,2011,7:173-183.
[8]崔永生,王晓军,张彬,等.老年重症肌无力的临床特点及外科治疗.中国老年学杂志,2007,27:175-176.
[9]魏蜀亮,邓志刚,赖应龙,等.老年重症肌无力手术75例治疗体会.湖南中医药大学学报,2010,30:51-53.
[10]Lucchi M, Van Schil P, Schmid R, et al. Thymectomy for thymoma and myasthenia gravis. A survey of current surgical practice in thymic disease amongst EACTS members. Interact Cardiovasc Thorac Surg,2012,14:765-770.
[11]Weksler B, Tavares J, Newhook TE, et al. Robotassisted thymectomy is superior to transsternal thymectomy. Surg Endosc,2012,26:261-266.
[12]Yu L, Zhang XJ, Ma S, et al. Thoracoscopic thymectomy for myasthenia gravis with and without thymoma: a singlecenter experience. Ann Thorac Surg,2012,93:240-244.
[13]Keating CP, Kong YX, Tay V, et al. VATS thymectomy for nonthymomatous myasthenia gravis: standardized outcome assessment using the myasthenia gravis foundation of America clinical classification. Innovations (Phila),2011,6:104-109.
[14]Zahid I, Sharif S, Routledge T, et al. Videoassisted thoracoscopic surgery or transsternal thymectomy in the treatment of myasthenia gravis? Interact Cardiovasc Thorac Surg,2011,12:40-46.
[15]Freeman RK, Ascioti AJ, Van Woerkom JM, et al. Longterm followup after robotic thymectomy for nonthymomatous myasthenia gravis. Ann Thorac Surg,2011, 92:1018-1023.
[16]Melfi F, Fanucchi O, Davini F, et al. Tenyear experience of mediastinal robotic surgery in a single referral centre. Eur J Cardiothorac Surg,2012,41:847-851.
[17]Goldstein SD, Yang SC. Assessment of robotic thymectomy using the Myasthenia Gravis Foundation of America Guidelines. Ann Thorac Surg,2010,89:1080-1086.
[18]Healey JS, Merchant R, Simpson C, et al. Canadian Cardiovascular Society/Canadian Anesthesiologists’ Society/Canadian Heart Rhythm Society joint position statement on the perioperative management of patients with implanted pacemakers, defibrillators, and neurostimulating devices. Can J Cardiol, 2012, 28:141-151.
[19]Strate T, Bloechle C, Broering D, et al. Hemostasis with the ultrasonically activated scalpel. Effective substitute for electrocautery in surgical patients with pacemakers. Surg Endosc,1999,13:727.
[20]谢琰臣,张华,赵媛,等.中国北方地区老年重症肌无力患者的临床特点.中国神经免疫学和神经病学杂志,2009,16:363-369.
[21]王维,隋波,李冠华,等.达芬奇机器人胸腺瘤切除术的麻醉管理.中国微创外科杂志,2011,11:706-708.
[22]陈秀,韩冰,郭巍,等.机器人胸腺扩大切除术治疗重症肌无力.实用医学杂志,2010,26:1997-1999.
[23]陈秀,李耀奇,韩冰,等.食管癌术中用达芬奇机器人游离胃的临床经验.腹腔镜外科杂志,2010,15:515-517.
[24]陈秀,韩冰,郭巍,等.胸外科应用达芬奇手术机器人的体会.临床外科杂志,2011,19:331-333.

备注/Memo

备注/Memo:
①麻醉科
更新日期/Last Update: 2014-01-08