[1]王丽,周丽雅,李渊,等.胃泌素在胃炎与胃癌中表达的差异及意义[J].中国微创外科杂志,2011,11(5):435-438.
　Wang Li,Zhou Liya,Li Yuan,et al.Difference between Benign and Malignant Gastric Diseases in the Level of Gastrin[J].Chinese Journal of Minimally Invasive Surgery,2011,11(5):435-438.
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胃泌素在胃炎与胃癌中表达的差异及意义()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
11
期数:
2011年5期
页码:
435-438
栏目:
实验研究
出版日期:
2011-05-20

文章信息/Info

Title:
Difference between Benign and Malignant Gastric Diseases in the Level of Gastrin
作者:
王丽; 周丽雅; 李渊; 金珠; 韩亚京
北京大学第三医院消化科，北京100191
Author(s):
Wang Li;  Zhou Liya;  Li Yuan; et al.
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
关键词:
胃泌素; 胃癌; 发生机制
Keywords:
Gastrin; Gastric cancer; Carcinogenesis
分类号:
R735.204
文献标志码:
A
摘要:
目的探讨胃炎与胃癌中，胃体、胃窦组织内胃泌素表达的水平的差异与意义。方法收集我院2009~2010年胃癌手术患者21例，选取同期行胃镜检查的慢性浅表性胃炎患者20例作为对照，免疫组化法检测组织内胃泌素的表达，IPP软件测定胃泌素累积光密度。结果不同性别及不同年龄胃泌素累积光密度的对数差异无显著性（P值分别为0.151和0.482）。胃炎组胃泌素累积光密度对数的中位数在胃体为2.58（1.60~4.24），胃窦为4.55（3.27~5.23）（Z=4.166，P=0.000）；癌组织与癌旁组织比较，胃体处癌为1.46（0.00~4.61），癌旁为3.51（0.00~5.30）（Z=3.089，P=0.002），胃窦处癌为0.00（0.00~4.23），癌旁为4.89（4.26~5.55）（Z=4.916，P=0.000）；癌旁组织与胃炎组相应部位比较，胃体处癌旁为351（0.00~5.30），胃炎组为2.58（1.60~4.24）（Z=2.397，P=0.017），胃窦处癌旁为4.89（4.26~5.55），胃炎组为4.55（327~5.23）（Z=2.193，P=0.028）；癌与胃炎组比较，胃体处癌为1.46（0.00~4.61），胃炎组为2.58（1.60~4.24）（Z=2578，P=0.010），胃窦处癌为0.00（0.00~4.23），胃炎组为4.55（3.27~5.23）（Z=4.828，P=0.000）。结论不同性别及不同年龄胃泌素表达差异无显著性。胃泌素在胃窦处表达高于胃体。无论胃体胃窦，癌旁、胃炎、癌组织中胃泌素表达呈递减趋势。胃泌素表达水平的变化可能为胃癌发生前的一种状态。
Abstract:
ObjectiveTo explore the relationship between gastrin and the development of gastric cancer by comparing gastrin level between benign and malignant gastric diseases at different locations. MethodsDuring 2009-2010, 21 patients with gastric cancer and 20 patients with gastritis who received operation or endoscopic examination in our hospital were enrolled in this study. The gastrin level in the lesions was determined by measuring cumulated IOD using IPP software after immunohistological staining.ResultsNo significant difference was detected in the logarithm of cumulated IOD of gastrin between different genders and among different ages. (P=0.151 and 0.482, respectively). In the gastritis group, the median level of gastrin in the gastric body was significantly lower than that in the antrum (2.58, 1.60-4.24 vs. 4.55, 3.27-5.23, Z=4.166, P=0.000). Such difference was also observed between carcinoma and paracarcinoma tissues, paracarcinoma and gastritis tissues, carcinoma and gastritis tissues, in both the gastric body and antrum ［carcinoma vs. paracarcinoma: 1.46 (0.00-4.61) vs. 3.51 (0.00-5.30) at the gastric body, Z=3.089, P=0.002; and 0.00 (0.00-4.23) vs. 4.89 (4.26-5.55) at the gastric antrum, Z=4.916, P=0.000. Paracarcinoma vs. gastritis: 3.51 (0.00-5.30) vs. 2.58 (1.60-4.24), Z=2.397, P=0.017 at the gastric body, and 4.89 (4.26-5.55) vs. 4.55 (3.27-523), Z=2.193, P=0.028) at the gastric antrum. Carcinoma vs. gastritis: 1.46 (0.00-461) vs. 2.58 (1.60-4.24), Z=2.578, P=0.010 at the gastric body, and 0.00 (0.00-4.23) vs. 4.55 (3.27-5.23), Z=4.828, P=0.000 at the gastric antrum］.ConclusionsThere exists no significant difference in the level of gastrin between different genders and among different ages. In both the gastric body and at the gastric sinus antrum, the level of gastrin is highest in paracarcinoma tissues, followed by gastritis and then carcinoma tissues. The fluctuation of gastrin level might be a precancerous status.

参考文献/References:

[1]Martinsen TC,Kawase S,Hakanson R,et al.Spontaneous ECL cell carcinomas in cotton rats: natural course and prevention by a gastrin receptor antagonist.Carcinogenesis,2003,24(12):1887-1896.
[2]Viste A,Ovrebo K,MaartmannMoe H,et al.Lanzoprazole promotes gastric carcinogenesis in rats with duodenogastric reflux.Gastric Cancer,2004,7(1):31-35.
[3]Norsett KG,Laegreid A,Kusnierczyk W,et al.Changes in gene expression of gastric mucosa during therapeutic acid inhibition.Eur J Gastroenterol Hepatol,2008,20(7):613-623.
[4]Jensen RT,Metz DC,Koviack PD,et al.Prospective study of the longterm efficacy and safety of lansoprazole in patients with the ZollingerEllison syndrome.Aliment Pharmacol Ther,1993,7 Suppl 1:41-50.
[5]Wang CJ,Zhou ZG,Holmqvist A,et al.Survivin expression quantified by Image ProPlus compared with visual assessment.Appl Immunohistochem Mol Morphol,2009,17(6):530-535.
[6]Edkins JS.The chemical mechanism of gastric secretion.J Physiol,1906,34(1-2):133-144.
[7]Watson SA,Grabowska AM,ElZaatari M,et al.Gastrinactive participant or bystander in gastric carcinogenesis?Nat Rev Cancer,2006,6(12):936-946.
[8]Cui G,Qvigstad G,Falkmer S,et al.Spontaneous ECLomas in cotton rats (Sigmodon hispidus):tumours occurring in hypoacidic/hypergastrinaemic animals with normal parietal cells.Carcinogenesis,2000,21(1):23-27.
[9]Ito M,Tanaka S,Maeda M,et al.Role of the gastringastrin receptor system in the expansive growth of human gastric neoplasms.Digestion,2008,78(2-3):163-170.
[10]Mishra P,Senthivinayagam S,Rangasamy V,et al.Mixed lineage kinase3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation.Mol Endocrinol,2010,24(3):598-607.
[11]Mishra P,Senthivinayagam S,Rrana A,et al.Glycogen synthase kinase3beta regulates snail and betacatenin during gastrininduced migration of gastric cancer cells.J Mol Biol,2010,5:9.
[12]Wang TC,Dangler CA,Chen D,et al.Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer.Gastroenterology,2000,118(1):36-47.
[13]Takaishi S,Tu S,Dubeykovskaya ZA,et al.Gastrin is an essential cofactor for helicobacterassociated gastric corpus carcinogenesis in C57BL/6 mice.Am J Pathol,2009,175(1):365-375.
[14]Lee CW,Rickman B,Rogers AB,et al.Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INSGAS mice.Cancer Res,2008,68(9):3540-3548.
[15]Hur K,Kwak MK,Lee HJ,et al.Expression of gastrin and its receptor in human gastric cancer tissues.J Cancer Res Clin Oncol,2006,132(2):85-91.
[16]Negre F,FagotRevurat P,Bouisson M,et al.Autocrine stimulation of AR42J rat pancreatic tumor cell growth by glycineextended gastrin.Int J Cancer,1996,66(5):653-658.
[17]Zhou JJ,Chen ML,Zhang QZ,et al.Coexpression of cholecystokininB/gastrin receptor and gastrin gene in human gastric tissues and gastric cancer cell line.World J Gastroenterol,2004,10(6):791-794.

备注/Memo

备注/Memo:
基金项目：国家自然基金30973415周丽雅通讯作者，Email：liyazhou@medmail.com.cn
更新日期/Last Update: 2013-04-18