[1]石丽萍,许学岚,王春平,等.腹腔镜手术联合GnRH激动剂治疗重度子宫内膜异位症120例临床分析[J].中国微创外科杂志,2010,10(7):629-631.
　Shi Liping,Xu Xuelan,Wang Chunping,et al.Laparoscopic Surgery Combined with GnRH Agonist for Severe Endometriosis: Analysis on 120 Cases[J].Chinese Journal of Minimally Invasive Surgery,2010,10(7):629-631.
点击复制

腹腔镜手术联合GnRH激动剂治疗重度子宫内膜异位症120例临床分析()
分享到：

《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
10
期数:
2010年7期
页码:
629-631
栏目:
出版日期:
2010-07-01

文章信息/Info

Title:
Laparoscopic Surgery Combined with GnRH Agonist for Severe Endometriosis: Analysis on 120 Cases
作者:
石丽萍; 许学岚; 王春平; 曾秀华
深圳市罗湖区人民医院妇产科，深圳518000
Author(s):
Shi Liping;  Xu Xuelan;  Wang Chunping;  et al.
Department of Gynecology, Luohu People’s Hospital, Shenzhen 518000, China
关键词:
子宫内膜异位症; 腹腔镜手术; GnRH激动剂
Keywords:
Endometriosis; Laparoscopic surgery; GnRH agonist
分类号:
R711.71
文献标志码:
A
摘要:
目的观察腹腔镜手术联合GnRH激动剂治疗重度子宫内膜异位症的疗效。 方法2004年7月～2008年7月我院对120例重度子宫内膜异位症采用腹腔镜手术治疗宫内膜异位病灶，术后给予达菲林或诺雷德治疗6个月。结果120例均行腹腔镜卵巢囊肿剥除术+盆腔粘连松解术+盆腔子宫内膜异位病灶电灼术，其中3例行宫骶韧带切断术，6例行双侧圆韧带悬吊术。120例随访6～60个月，平均26个月，复发率8.3%（10/120），73例合并不孕治疗后1年自然妊娠率425%（31/73）。结论腹腔镜手术联合GnRH激动剂治疗重度子宫内膜异位症临床效果满意。
Abstract:
ObjectiveTo evaluate the efficacy of laparoscopy combined with GnRH agonist in the treatment of severe endometriosis. MethodsFrom July 2004 to July 2008, we performed laparoscopy on 120 patients with severe endometriosis, after the operation, triptorelin acetate or Zoladex were administered for 6 months. ResultsAll of the cases received laparoscopic oophorocystectomy+ lysis for pelvic adhesion + coagulation of pelvic endometriosis. Three patients underwent uterosacral ligament amputation, and six patients received bilateral round ligament suspension. The 120 patients were followed up for 6 to 60 months with a mean of 26 months, 10 of them (8.3%) showed recurrent lesions during the period. Of the cases, 73 patients received treatments for infertility, 31 of them had natural pregnancy in one year (42.5%). ConclusionLaparoscopy combined with GnRH agonist is an effective method for the treatment of severe endometriosis.

参考文献/References:

[1]Brosens IA，Comillie F，Koninckx P，et al.Evolution of revised American.Fertility Society Classification of endometriosis.Fertil Steril，1985，45：347-350.
[2]曹泽毅，主编.中华妇产科学.北京：人民卫生出版社，1999.2219.
[3]乐杰. 主编.妇产科学. 第7版.北京：人民卫生出版社，2008.249-250.
[4]周应芳.腹腔镜手术在子宫内膜异位症中的应用.中国实用妇科与产科杂志，2007，23（8）：589-591.
[5]周应芳,崔恒,乔杰,等. 应重视子宫内膜异位症诊断与治疗的规范化. 中国妇产科临床杂志,2001,2(2):68-71.
[6]Lebovic DI, Chao VA, Martini JF, et al. ILlbeta induction of RANTES (regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factorkappa B site in the proximal promoter. J Clin Endocrinol Metab,2001, 86(10): 4759-4764.
[7]刘晓瑛,李宝艳,周维,等. 腹腔镜手术加用GnRH-A治疗子宫内膜异位症.中国临床医学,2005,12(5):941.
[8]Tsai YL, Hwang JL, Loo TC, et al. Shortterm postoperative GnRH analogue or danazol treatment after conservative surgery for stage Ⅲ or Ⅳ endometriosis before ovarian stimulation: a prospective, randomized study. J Reprod Med, 2004, 49(12):955-959.
[9]Malinowski A, Nowak M, MaciolekBlewniewska G, et al. The place of laparoscopy in gynecological practice-useful technique for diagnostic and treatment of infertility and endometriosis. Ginekol Pol, 2001, 72(12A):1347-1354.
[10]Kupker W, Felberbaum RE, Krapp M, et al. Use of GnRH antagonists in the treatment of endometriosis. Reprod Biomed Online, 2002, 5(1) :12-16. [11]Rickes D, Nickel I, Kropf S, et al. Increased pregnancy rates after ultra long postoperative therapy with gonadotropinreleasing hormone analogs in patients with endometriosis. Fertil Steril, 2002, 78(4): 757-762.
[12]宋作林.子宫内膜异位症的研究与临床指南.成都：四川科学技术出版社， 2005. 199-200.

更新日期/Last Update: 2013-08-12