[1]柯明耀,陈玲玲,吴雪梅,等.经皮微波热凝固联合125I放射性粒子植入治疗晚期肺癌[J].中国微创外科杂志,2009,09(5):432-434.
　Ke Mingyao,Chen Lingling,Wu Xuemei,et al.Percutaneous Microwave Coagulation Therapy Combined with 125I Seeds Implantation for Advanced Lung Cancer[J].Chinese Journal of Minimally Invasive Surgery,2009,09(5):432-434.
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经皮微波热凝固联合125I放射性粒子植入治疗晚期肺癌()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
09
期数:
2009年5期
页码:
432-434
栏目:
出版日期:
2009-08-01

文章信息/Info

Title:
Percutaneous Microwave Coagulation Therapy Combined with 125I Seeds Implantation for Advanced Lung Cancer
作者:
柯明耀; 陈玲玲; 吴雪梅; 林玉妹; 雍雅智; 罗炳清
厦门市第二医院厦门市呼吸中心，厦门361021
Author(s):
Ke Mingyao;  Chen Lingling;  Wu Xuemei;  et al.
Respiration Center, Xiamen Second Hospital, Xiamen 361021, China
关键词:
肺癌; 经皮微波热凝固; 碘放射性同位素; 近距离放射疗法
Keywords:
Lung cancer; Percutaneous microwave coagulation; Iodine radioisotopes; Brachytherapy
分类号:
R734.2;R730.55
文献标志码:
A
摘要:
目的探讨经皮微波凝固治疗(percutaneous microwave coagulation therapy, PMCT)联合125I放射性粒子植入治疗晚期肺癌的临床疗效及可行性。方法22例晚期肺癌（鳞癌15例，腺癌7例），瘤体最大径5～12 cm，在CT引导下行PMCT联合125I放射性粒子植入治疗。病灶位于胸壁上或大血管、大气道周围的部分划为粒子治疗区域，其他病灶的大部分区域为PMCT区域。结果22例PMCT均为1次手术、多点治疗，共植入125I粒子712颗，平均每例植入32.4颗粒子。术后2个月并发症包括少量咯血(7例)、气胸（4例）、PMCT术后发热（17例）、肺部炎症（11例）、少量胸腔积液（6例）及粒子移位（2例）。PR 15例，SD 5例，PD 2例，有效率68.2％（15/22）。15例术前疼痛者治疗后疼痛完全消失（11例）或明显减轻（4例）。22例随访4～18个月，平均7个月，PR、SD的病灶均未见增大。结论PMCT联合125I粒子植入治疗病灶≥5 cm的晚期肺癌疗效肯定、微创、安全。
Abstract:
ObjectiveTo evaluate the efficacy and feasibility of percutaneous microwave coagulation therapy (PMCT) combined with 125I seeds implantation for the treatment of advanced lung cancer.Methods CTguided PMCT and implantation of 125I seeds were applied to 22 cases of NSCLC, including 15 cases of squamous carcinoma and 7 cases of adenocarcinoma. The maximum diameter of the lesions ranged from 5-12 cm. The part of focuses situated at thoracic wall or surrounding the large vessels and airways was treated with 125I seed implantation, and the other parts were treated with PMCT. ResultsIn all the patients, PMCT was done in one session with multipoint ablation, and an average of 32.4 particles of 125I seeds were implanted for each of the focuses (712 particles in total). The main postoperative complications included slight hemoptysis (7 cases), pneumothorax (4 cases), fever (17) and lung inflammation (11) after PMCT, chest fluid (6), and dislocation of the particles (2).15 cases achieved PR, 5 cases were SD, and 2 cases were PD in 2 months after the operation shown by CT. The effective rate (CR + PR) was 68.2% (15/22). The chest pain was relieved in 15 patients, and improved in 4. 22 of the cases were followed up for 4 to 18 months (mean 7 months). No enlargement of the chest lesion was detected during the period. ConclusionsFor the advanced NSCLC sized ≥ 5 cm in diameter, PMCT combined with 125I seeds implantation is safe, minimally invasive, and effective.

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更新日期/Last Update: 2013-08-19