[1]陈智毅,梁伟翔,梁琨①.不同卵泡抽吸治疗模式对氯米芬抵抗多囊卵巢综合征的疗效[J].中国微创外科杂志,2009,09(3):196-198.
　*Chen Zhiyi,*Liang Weixiang,Liang Kun..Therapeutic Effects of Different Approaches for Transvaginal UltrasoundGuided Follicular Aspiration in Infertile Patients with Clomiphene CitrateResistant Polycystic Ovary Syndrome[J].Chinese Journal of Minimally Invasive Surgery,2009,09(3):196-198.
点击复制

不同卵泡抽吸治疗模式对氯米芬抵抗多囊卵巢综合征的疗效()
分享到：

《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
09
期数:
2009年3期
页码:
196-198
栏目:
出版日期:
2009-08-01

文章信息/Info

Title:
Therapeutic Effects of Different Approaches for Transvaginal UltrasoundGuided Follicular Aspiration in Infertile Patients with Clomiphene CitrateResistant Polycystic Ovary Syndrome
作者:
陈智毅; 梁伟翔; 梁琨①
广州医学院第三附属医院医学超声科，广州510150
Author(s):
*Chen Zhiyi;  *Liang Weixiang;  Liang Kun.
*Department of Medical Ultrasound, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China
关键词:
多囊卵巢综合征; 不孕; 超声; 卵泡; 抽吸
Keywords:
Polycystic ovary syndrome; Infertility; Ultrasound; Follicle; Aspiration
分类号:
R711.75
文献标志码:
A
摘要:
目的比较2种不同模式的卵泡抽吸术（follicular aspiration，FA）对氯米芬（clomifene citrate，CC）抵抗型多囊卵巢综合征（polycystic ovary syndrome，PCOS）不孕的治疗效果。方法2005年12月~2007年12月，将85例CC抵抗PCOS不孕症分为2组，均在经阴道超声（transvaginal ultrasound，TVU）介导下手术。组Ⅰ为彻底手术组30例，即抽吸所有卵泡；组Ⅱ为常规组38例，仅抽吸较大的卵泡。通过TVU和激素水平的检测，分析两种治疗模式对患者内分泌、排卵率和妊娠率的影响。结果组Ⅰ累积排卵率和妊娠率均优于组Ⅱ［833％(25/30) vs 421％(16/38)， χ2＝11903，P=0001；433％(13/30) vs 132％(5/38)， χ2＝7843，P=0005］，组Ⅰ术后黄体生成素和睾酮水平较术前明显下降［（1768±311） vs (1158±184),t＝9220，P=0000；(341±214) vs (147±129),t＝3937，P=0000］，而组Ⅱ无明显改善［（1776±451）vs (1611±353),t＝0229，P=0062；(388±154) vs (372±127),t＝0995，P=0326］。结论彻底穿刺抽吸所有小卵泡能明显改善CC抵抗型PCOS不孕患者的内分泌状况，有效提高排卵率和妊娠率。
Abstract:
ObjectiveTo compare the effectiveness of two different modes of follicular aspiration (FA) guided by transvaginal ultrasound (TVU) in infertile patients with clomiphene citrate (CC)resistant polycystic ovary syndrome (PCOS).MethodsFrom December 2005 to December 2007,85 patients with CCresistant PCOS were randomly divided into two groups. Group Ⅰ (thorough treatment) had the every possible small follicles being punctured and aspirated, while group Ⅱ (routine operation) only had the larger follicles being operated. These patients were monitored with TVU and testing the steroid hormone levels. The effect of the two methods on the hormone levels and rates of ovulation and pregnancy were analyzed. ResultsAfter the treatments, the cumulative rates of ovulation and pregnancy in the group Ⅰ were higher than those in the group Ⅱ ［833％(25/30) vs 421％(16/38), χ2＝11903, P＝0001; 433％(13/30) vs 132％(5/38), χ2＝7843, P＝0005］. Moreover, the levels of luteinizing hormone (LH) and testosterone (T) were decreased significantly after the treatment in group Ⅰ ［(1768±311) vs (1158±184), t＝9220, P=0000; (341±214) vs (147±129), t＝3937, P=0000］, whereas those in group Ⅱ were not improved markedly ［(1776±451) vs (1611±353), t＝0229, P=0062; (388±154) vs (372±127), t＝0995, P=0326］.ConclusionsThorough treatment that has the every possible small follicle being punctured and aspirated can significantly improve the endocrinological abnormalities, and increase the rates of ovulation and pregnancy in patients with CCresistant PCOS.

参考文献/References:

[1]Lidor AL,Goldenberg M,Cohen SB,et al.Management of women with polycystic ovary syndrome who experienced premature luteinization during clomiphene citrate treatment.Fertil Steril，2000,74(4):749-752.
[2]Branigan EF,Fstes MA.A randomized clinical trial of treatment of clomiphene citrateresistant anovulation with the use of oral contraceptive suppression and repeat clomiphene citrate treatment.Am J Obstet Gynecol,2003,188(6):1424-1429.
[3]Heijnen EM,Eijkemans MJ,Hughes EG,et al.A metaanalysis of outcomes of conventional IVF in women with polycystic ovary syndrome.Hum Reprod Update,2006,12(1):13-21.
[4]梁伟翔,陈智毅,陈 霞,等.阴道超声引导下选择性卵泡减少术对PCOS不孕症患者的疗效观察.广东医学,2008,29(1):240-242.
[5]The Rotterdam ESHRE/ASRMsponsored PCOS consensus workshop group.Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS).Hum Reprod,2004,19(1):41-47.
[6]Lunde1 O,Djseland O,Grttum P.Polycystic ovarian syndrome:a followup study on fertility and menstrual pattern in 149 patients 15-25 years after ovarian wedge resection.Hum Reprod,2001,16(7):1479-1485.
[7]Parsanezhad ME,Alborzi S,Zolghadri J,et al.Hyperprolactinemia after laparoscopic ovarian drilling:An unknown phenomenon.Reprod Biol Endocrinol,2005,3:31.

备注/Memo

备注/Memo:
基金项目：广东省科技厅科技计划项目（2006B35930001）①妇产科
更新日期/Last Update: 2013-08-19