[1]周小龙①,李龙,吴璇昭②,等.腹腔镜治疗腹股沟斜疝对小儿血CRP、IL6、IL10的影响[J].中国微创外科杂志,2009,09(1):66-68.
　Zhou Xiaolong,Li Long*,Wu Xuanzhao,et al.Effect of Laparoscopic Repair of Inguinal Hernia on the Serum Levels of Cytokine IL6, IL10, and CRP in Children[J].Chinese Journal of Minimally Invasive Surgery,2009,09(1):66-68.
点击复制

腹腔镜治疗腹股沟斜疝对小儿血CRP、IL6、IL10的影响()

《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
09
期数:
2009年1期
页码:
66-68
栏目:
实验研究
出版日期:
2009-08-01

文章信息/Info

Title:
Effect of Laparoscopic Repair of Inguinal Hernia on the Serum Levels of Cytokine IL6, IL10, and CRP in Children
作者:
周小龙①; 李龙; 吴璇昭②; 刘树立; 侯文英
首都儿科研究所小儿外科，北京100020
Author(s):
Zhou Xiaolong;  Li Long*;  Wu Xuanzhao;  et al.
*Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing 100020, China
关键词:
腹腔镜手术; 开腹手术; 白细胞介素6; 白细胞介素10; C反应蛋白
Keywords:
Laparoscopic surgery; Open surgery; IL6; IL10; Creactive protein
分类号:
R726.1；R446.6
文献标志码:
A
摘要:
目的探讨腹腔镜治疗小儿腹股沟斜疝手术前后外周血C反应蛋白（Creactive protein,CRP）、白细胞介素6（IL6）、白细胞介素10（IL10）的变化。方法将50例腹股沟斜疝的患儿按抽签方式分为腹腔镜组和开放组各25例。腹腔镜组行腹腔内环口疝囊结扎术；开放组行腹股沟部切开疝囊高位结扎。于手术前1天早晨空腹、术后即刻、术后第2天早晨空腹采外周静脉血，用ELISA法测定血中的CRP、IL6、IL10的含量。结果2组术后即刻CRP、IL6、IL10比手术前有显著升高（腹腔镜组q=8508、11307、22111,P＜005；开放组q=7938、16668、21707，P＜0.05）；但开放组上述指标明显高于腹腔镜组（t=-3106，P=0005；t=-4509，P=0000；t=-4745，P=0000）。术后第2天，与术前相比，腹腔镜组CRP、IL6、IL10差异无显著性（q=0086、0482、3853，P＞005）；而开放组仍高于术前（q=3845、10599、11379,P＜005）。2组相比，开放组明显高于腹腔镜组（t=-3130，P=0005；t=-5051，P=0000；t=-3730，P=0001）。结论与开放手术相比，腹腔镜治疗腹股沟斜疝引起CRP、IL6、IL10的改变较小，因而，腹腔镜手术对小儿机体的免疫抑制作用小，持续时间短。
Abstract:
ObjectiveTo explore the changes of CRP, IL6, and IL10 levels after laparoscopic or open repair of inguinal hernia in children.MethodsFifty children with inguinal hernia were randomly assigned to laparoscopic repair or open surgery groups (25 in each). In the laparoscopic group (LS group), the hernia sac was closed by ligating the inner ring, while in the open surgery group (OS group), high ligation was performed. The peripheral blood samples of the two groups were collected one day before, immediately after, and one day after the operations. ELISA was used to detect the levels of CRP, IL6, and IL10.ResultsIn both the groups, the levels of CRP, IL6, and IL10 were significantly increased immediately after the surgeries (LS Group: q=8508, 11307, and 22111, P<005; OS Group: q=7938, 16668, and 21707, P<005). On the second day postoperation, the levels of CRP, IL6, and IL10 in the LS group were similar to those before the surgery (q=0086, 0482, and 3853, P>005), while in the OS group, the levels remained significantly higher (q=3845, 10599, and 11379, P<005). Compared to the LS group, the postoperative levels of CRP, IL6, and IL10 in the OS group were significantly higher (t=-3106, P=0005; t=-4509, P=0000; and t=-4745, P=0000 for immediately postoperation, and t=-3130, P=0005; t= -5051, P=0000; and t=-3730, P=0001 for one day after the operation).ConclusionSince the changes of CRP, IL6, and IL10 levels are smaller after laparoscopic surgery than those after open surgery, we consider that laparoscopic surgery leads to lower and shorter immunosuppressive effects.

参考文献/References:

[1]田文，李荣，陈凛.结直肠癌腹腔镜切除术对机体应激反应影响的临床研究.中国普外基础与临床杂志，2004，11（3）：204-206.
[2]曹铭辉,陈亚进,张红卫,等，腹腔镜肝切除术患者细胞免疫功能的变化.中华麻醉学杂志,2004,24(10):751-753.
[3]Rahr HB,Bendix J,Ahlburg P,et al.Coagulation, inflammatory, and stress responses in a randomized comparison of open and laparoscopic repair of recurrent inguinal hernia.Surg Endosc,2006,20:468-472.
[4]Akhtar K,Kamalkyasl ID,Lamb WR,et al.Metabolic and inflammatory responses after laparoscopic and open inguinal hernia.Ann R Coll Sur Eng,1998,80:125-130.
[5]Schwab R,Eissele S,Brückner UB,et al.Systemic inflammatory response after endoscopic (TEP) vs Shouldice groin hernia repair.Hernia，2004，8:226-232.
[6]Sherry RM，Cue JI,Goddard JR，et al.Interleukin10 is associated with the development of sepsis in trauma patients.Trauma,1996,40(4):613-617.
[7]赵倩,边爱平,封全灵,等.腹腔镜筋膜内子宫切除术对机体免疫功能影响的随机对照研究.中国微创外科杂志,2005,5(10):813-816.
[8]Decker D,Schondorf M，Bidlingmaier F,et al.Surgical stress induces a shift in the type1/type2 Thelper cell balance,suggesting downregulation of cellmediated and upregulation of antibodymediated immunity commensurate to the trauma.Surgery,1996，119(3):316-325.

备注/Memo

备注/Memo:
李龙通讯作者,①现工作单位：江西省赣南医学院,赣州341000②(贵阳医学院附属医院小儿外科,贵阳550004)
更新日期/Last Update: 2014-01-08