[1]孙志刚,陆涛,卢榜裕**,等.腔镜与传统甲状腺手术对机体免疫功能的影响[J].中国微创外科杂志,2009,09(1):62-65.
　Sun Zhiguang,Lu Tao,Lu Bangyu,et al.Influence of Endoscopic and Open Thyroidectomies on Immune Function[J].Chinese Journal of Minimally Invasive Surgery,2009,09(1):62-65.
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腔镜与传统甲状腺手术对机体免疫功能的影响()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
09
期数:
2009年1期
页码:
62-65
栏目:
实验研究
出版日期:
2009-08-01

文章信息/Info

Title:
Influence of Endoscopic and Open Thyroidectomies on Immune Function
作者:
孙志刚; 陆涛; 卢榜裕**; 陆文奇
广西医科大学第一附属医院微创外科中心，南宁530021
Author(s):
Sun Zhiguang;  Lu Tao;  Lu Bangyu;  et al.
Center of Minimally Invasive Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
关键词:
甲状腺切除术; 腔镜; 免疫功能
Keywords:
Thyroidectomy; Endoscopic; Immunity
分类号:
R653；R392
文献标志码:
A
摘要:
目的比较乳晕入路腔镜和传统开放甲状腺部分切除术对患者免疫功能的影响。方法将50例适合甲状腺部分切除术患者分为腔镜组（n=25）和开放组（n=25）。于术前1天，术后第1天、第2天和第3天分别采集外周静脉血，流式细胞仪检测外周血淋巴细胞亚群(CD3、CD4+和CD8+ T淋巴细胞比例)，免疫散射比浊法测定免疫球蛋白（IgA、IgG和IgM），C反应蛋白（CRP）及补体C3、C4含量。结果在腔镜和开放组，CD3、CD8+ T淋巴细胞和补体C4在术后1天较术前均明显下降（P＜005）,IgG和补体C3在术后1天和2天较术前均明显下降（P＜001）,CRP在术后1天和2天较术前均明显上升（P＜005）；但2组间，各免疫指标的变化差异无显著性（P＞005）。结论乳晕入路腔镜甲状腺手术和传统开放手术对机体免疫功能均有一定程度的抑制作用，但差异无显著性。
Abstract:
ObjectiveTo compare the influence of endoscopic thyroidectomy via breast areola approach and traditional thyroidectomy on the immune function.MethodsFifty cases undergoing partial thyroidectomy were divided into endoscopy and open thyroidectomy groups (25 cases in each). Blood samples were obtained at 1 day before the surgery and 1, 2, and 3 days postoperation to count the CD3, CD+4 and CD+8 T lymphocytes using flow cytometry, and determine the concentration of immunoglobulins (IgG, IgA, and IgM), CRP, and complements (C3 and C4) with immunonephelometry.ResultsIn both the groups, the concentrations of CD3, CD+8 T lymphocytes, and complement C4 decreased significantly at 24 hours after the surgery (P＜0.05), and the levels of IgG and C3 decreased significantly at both 24 and 48 hours postoperation (P＜0.01); while the concentration of CRP increased significantly at 24 and 48 hours after the operaiton (P＜0.05). No significantly difference in the immune parameters was detected between the two groups（P＞005）.ConclusionsBoth endoscopic and traditional thyroidectomy could depress the immune function, however no significant difference exists between the two methods in the level of depression.

参考文献/References:

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备注/Memo

备注/Memo:
广西壮族自治区卫生厅自筹经费课题（桂Z2006035）**通讯作者
更新日期/Last Update: 2014-01-08