[1]石彬,刘德若,郭永庆,等.经纤维支气管镜冷冻治疗中、晚期中心型肺癌致气道梗阻的疗效[J].中国微创外科杂志,2008,08(11):964-966.
　Shi Bin,Liu Deruo,Guo Yongqing,et al.Cryosurgery for Middle and Late Stage Central Lung Cancer with Fiber Optic Bronchoscopy[J].Chinese Journal of Minimally Invasive Surgery,2008,08(11):964-966.
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经纤维支气管镜冷冻治疗中、晚期中心型肺癌致气道梗阻的疗效()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
08
期数:
2008年11期
页码:
964-966
栏目:
出版日期:
2008-11-05

文章信息/Info

Title:
Cryosurgery for Middle and Late Stage Central Lung Cancer with Fiber Optic Bronchoscopy
作者:
石彬; 刘德若; 郭永庆; 田燕雏; 宋之已; 寿延宁; 张海涛; 梁朝阳; 陈京宇; 王在永; 鲍彤
卫生部中日友好医院胸外科，北京100029
Author(s):
Shi Bin;  Liu Deruo;  Guo Yongqing;  et al.
Department of Thoracic Surgery, ChinaJapan Friendship Hospital, Beijing 100029, China
关键词:
肺癌; 纤维支气管镜; 冷冻
Keywords:
Lung cancer; Fiber optic bronchoscope; Cryosurgery
分类号:
R734.2
文献标志码:
A
摘要:
目的探讨经纤维支气管镜冷冻治疗中、晚期中心型肺癌的疗效。方法经纤维支气管镜用液态CO2对31例不适合常规开胸手术的中、晚期中心型肺癌患者进行冷冻治疗,并与治疗前比较,以观察其疗效。操作方法：将冷冻探针经支气管镜活检孔插入,置于肿瘤中心或边缘，冷冻约30～120 s，冷冻温度-50～-70 ℃，在其探针顶端形成的冰球未完全溶解前“撕脱”切除肿瘤，反复多次操作直至管腔再通。结果经1~6次（平均25次）治疗，症状缓解率：咳嗽74%（23/31）、咯血87%（27/31）、呼吸困难87%（27/31），胸痛58%（18/31）。显效61%(19/31)，有效39%(12/31)。肺功能改善：第一秒用力呼气容积（FEV1）从（121±022）L提高到（172±035）L (t=21843,P=0001)，用力肺活量(FVC)从(186±031)L提高到(226±043)L (t=33703,P=0001)。结论经纤维支气管镜冷冻治疗能使管腔得以重新疏通,使阻塞性肺炎得到控制,呼吸困难和咯血得到改善,生活质量明显提高，是一种简便有效的微创治疗方法。
Abstract:
ObjectiveTo evaluate the effectiveness of cryosurgery by using fiber optic bronchoscope for the treatment of middle or late stage central lung cancer.MethodsCryosurgery was performed on 31 patients with middle or late stage central lung cancer, who could not received open surgery, with liquid CO2 by using fiber optic bronchoscope. The effectiveness was monitored. Via the bronchoscope, a cryoprobe was inserted to the center or margin of the tumor. The cryotherapy was persisted for 30 to 120 seconds at －50 to －70 ℃. And then, the tumor was removed before the iceball on the point of the probe thawed. The procedure was repeated for several times till the airway was reopened.ResultsAfter 1 to 6 times therapies (25 times on average), the improve rates of cough, hemoptysis, dyspnea, and chest pain were 74% (23/31), 87% (27/31), 87% (27/31), and 58% (18/31), respectively. The rates of “markedly effective”and “effective” were 61% (19/31) and 39% (12/31) respectively. The pulmonary function of the patients was also improved: the FEV1 rose from (121±022) L to (172±035）L (t=21843, P=0001), and the FVC was increased from (186±031) L to (226±043) L (t=33703, P=0001).ConclusionsCryosurgery by using a fiber optic bronchoscope is an effective and minimally invasive method to reopen the airway, control the obstructive pneumonia, and improve dyspnea and hemoptysis.

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更新日期/Last Update: 2013-10-23