[1]王成锋,田艳涛,张建伟.不明原发灶肿瘤1273例报告[J].中国微创外科杂志,2007,07(11):1072-1074.
　Wang Chengfeng,Tian Yantao,Zhang Jianwei,et al.Unknown Primary Tumors: Report of 1273 Cases[J].Chinese Journal of Minimally Invasive Surgery,2007,07(11):1072-1074.
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不明原发灶肿瘤1273例报告()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
07
期数:
2007年11期
页码:
1072-1074
栏目:
出版日期:
2007-11-20

文章信息/Info

Title:
Unknown Primary Tumors: Report of 1273 Cases
作者:
王成锋; 田艳涛; 张建伟
中国医学科学院肿瘤医院中国协和医科大学肿瘤学院腹部肿瘤外科，北京100021
Author(s):
Wang Chengfeng;  Tian Yantao;  Zhang Jianwei;  et al.
Department of Abdominal Tumor Surgery,Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
关键词:
不明原发灶肿瘤; 流行病学; 诊断
Keywords:
Unknown primary tumor; Epidemiology; Diagnosis
分类号:
R730.4
文献标志码:
A
摘要:
目的探讨不明原发灶肿瘤(unknown primary tumor，UPT)的临床特点、诊断标准及治疗。方法回顾性分析我院1959年1月～2004年12月45年1273例UPT的临床资料，包括好发部位、肿瘤的组织类型、治疗方式等。结果UPT好发部位为淋巴结（67.0%，尤其是颈部淋巴结）；病理类型以腺癌为主（71.8%）；所有病例均无相关肿瘤病史，组织学检查获得恶性证据，肿瘤标志物无特异性升高，B超、CT、MRI、PETCT等检查后未发现原发肿瘤。477例（35.7%）行手术治疗，其中完整切除387例（81.8%）；791例（62.1%）进行放化疗；4例进行生物治疗；1例未治疗。随诊率26.5％（337/1273）,获随访病例诊断后生存时间1~145月，中位生存时间4.8月。结论UPT是恶性肿瘤患者中常见的临床综合征，诊断标准为：组织学证实为恶性肿瘤；首发部位周围未发现原发病灶；经详尽的病史采集、体格检查、肿瘤标志物和多种影像学检查均未发现或提示原发肿瘤者。虽然尚无统一的治疗模式，治疗应是以手术为主的综合治疗，但UPT的总体预后差。
Abstract:
ObjectiveTo investigate the clinical features, diagnostic criteria, and treatment of unknown primary tumor (UPT).MethodsThe clinical data, including susceptible locations, histological types, and therapies of 1273 patients with UPT, who was admitted to our hospital from January 1959 to December 2004, were analyzed retrospectively.ResultsThe susceptible locations of UPT were lymph nodes (67.0%), especially the cervical lymph nodes. Most of the tumors were adenocarcinomas (718%). No tumor history, histological evidence, and specifically increased tumor markers were detected in the cases. No primary tumor was found by Bultrasonography, CT, MRI, and PETCT. A total of 477 cases (35.7%) underwent operations, 387 of them (81.8%) had a radical resection. 791 cases（621%） received comprehensive therapy, 4 underwent biotherapy, and 1 received no treatment. Followup ratio was 26.5% (337/1273). The median survival time was 4.8 months (range, 1-14.5). ConclusionsUPT is a common clinical syndrome in patients with malignant tumor. The diagnostic criteria of the disease are as following: Histologically confirmed malignance; no primary focus around the primary location; primary focus cannot be found by collecting detailed information of past medical history, physical examination, tumor markers test, image examinations, etc. Surgery combined with comprehensive therapy is recommended for the disease. The prognosis of UPT is poor.

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更新日期/Last Update: 2013-12-09