[1]栾景源,董国祥,刘鹏①,等.电凝及激光治疗下肢静脉曲张的病理研究[J].中国微创外科杂志,2007,07(3):289-292.
　Luan Jingyuan*,Dong Guoxiang*,Liu Peng,et al.A pathological study on electrocoagulation and laser treatment for varicose veins of the lower extremity[J].Chinese Journal of Minimally Invasive Surgery,2007,07(3):289-292.
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电凝及激光治疗下肢静脉曲张的病理研究()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
07
期数:
2007年3期
页码:
289-292
栏目:
实验研究
出版日期:
2007-03-20

文章信息/Info

Title:
A pathological study on electrocoagulation and laser treatment for varicose veins of the lower extremity
作者:
栾景源; 董国祥; 刘鹏①; 赵军; 李天润
北京大学第三医院介入血管外科，北京100083
Author(s):
Luan Jingyuan*;  Dong Guoxiang*;  Liu Peng;  et al.
*Department of Vascular Surgery, Peking University Third Hospital, Beijing 100083, China
关键词:
静脉曲张; 微创治疗; 电凝; 激光; 病理
Keywords:
Varicose veins; Minimally invasive treatment; Electrocoagulation; Laser; Pathology
分类号:
R654.3;R454.2
文献标志码:
A
摘要:
目的观察电凝和激光对静脉的破坏程度，比较两种方法对曲张下肢静脉闭塞的差异。方法20例静脉曲张患者，分别接受电凝（n=10）和激光（n=10）治疗后取材静脉比较病理变化。8只犬随机分为2组，分别用常规电凝、激光法处理后肢内侧隐静脉，术后即刻、7天、14天取材，观察静脉病理变化。结果电凝和激光治疗后均可见静脉壁内皮细胞脱落、平滑肌细胞结构不清、弹力纤维和胶原纤维断裂、腔内血栓形成、管腔闭塞；7天时血栓部分机化并与管壁粘连，两组均出现缝隙样微小再通；14天时胶原纤维、平滑肌细胞、弹力纤维增生，血栓完全机化，再通情况变化不明显。 结论电凝和激光均可导致静脉闭塞，是治疗下肢静脉曲张的有效方法。
Abstract:
ObjectiveTo observe pathological changes of varicose veins after electrocoagulation and endovenous laser treatment (EVLT) and to compare the efficacy between electrocoagulation and EVLT for the treatment of varicose veins of the lower extremity.MethodsTwenty patients with varicose veins of the lower extremity were treated with either electrocoagulation (n=10) or EVLT (n=10). Histopathological changes of varicose veins were observed. Eight dogs were randomly divided into 2 groups and treated with electrocoagulation or EVLT. The treated veins were taken out at 0, 7, and 14 days after operation, for histopathological examinations.ResultsAfter electrocoagulation or EVLT, the endothelial cells of varicose veins were absent, the structure of smooth muscle cells was indistinct, broken collagenous fibers and elastic fibers were observed, and thrombosis leading to occlusion was observed in the lumen. Incomplete thrombus organization and conglutination with the walls were observed 7 days after operation. Mild recanalization was found in both groups. On the 14th postoperative day, the hyperplasia of smooth muscle cells, collagenous fibers, and elastic fibers was detected. Complete thrombus organization was seen, and recanalization presented no obvious changes.ConclusionsBoth electrocoagulation and EVLT can lead to the occlusion of varicose veins, being effective therapeutic alternatives for varicose veins of the lower extremity.

参考文献/References:

[1]高君军，薛志高，黄俊华.腔内微波凝固治疗下肢静脉曲张28例.中华普通外科杂志，2005，20(2):132.
[2]董国祥.电凝法治疗下肢静脉曲张.现代外科（现名中国微创外科杂志）,1999,5(4):6-7.
[3]刘鹏，王非，林凡，等.激光联合透光直视旋切术治疗下肢静脉曲张.中国微创外科杂志，2005，5(3):229-231.
[4]王风安，闫庆辉，廖海鹰，等.大隐静脉曲张扫描电镜观察.河北医科大学学报，1997，8(5)：267-269.
[5]韩丽娜，王春喜，顾瑛.激光光凝后曲张大隐静脉的组织病理学变化.中国激光医学杂志，2005,14(3):173-176.
[6]Min RJ,Zimmet SE,Isaacs MN,et al.Endovenous laser treatment of the incompetent greater saphenous vein.J Vasc Interv Radiol,2001,12(10):1167-1171.
[7]Min RJ,Khilnani N,Zimmet SE.Endovenous laser treatment of saphenous vein reflux:longterm results.J Vasc Interv Radiol,2003,14:991-996.

备注/Memo

备注/Memo:
①刘鹏(中日友好医院心脏血管外科，北京100029)
更新日期/Last Update: 2013-11-15