[1]王俊杰,冉维强,姜玉良,等.超声引导放射性125I粒子植入治疗头颈部复发或转移癌[J].中国微创外科杂志,2007,07(2):120-122.
 Wang Junjie,Ran Weiqiang,Jiang Yuliang,et al.Ultrasound guided 125I seed interstitial brachytherapy for recurrent or metastatic head and neck cancer[J].Chinese Journal of Minimally Invasive Surgery,2007,07(2):120-122.
点击复制

超声引导放射性125I粒子植入治疗头颈部复发或转移癌()
分享到:

《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
07
期数:
2007年2期
页码:
120-122
栏目:
出版日期:
2007-02-20

文章信息/Info

Title:
Ultrasound guided 125I seed interstitial brachytherapy for recurrent or metastatic head and neck cancer
作者:
王俊杰冉维强姜玉良刘江平李金娜姜伟娟江萍
北京大学第三医院肿瘤治疗中心放射治疗科,北京100083
Author(s):
Wang Junjie Ran Weiqiang Jiang Yuliang et al.
The Cancer Center, Peking University Third Hospital, Beijing 10083, China
关键词:
125I粒子 植入术 头颈部癌 超声
Keywords:
125I seedImplantationHead and neck cancerUltrasound
分类号:
R739.41;R817.8
文献标志码:
A
摘要:
目的探讨超声引导下放射性125I粒子组织间植入治疗头颈部肿瘤的技术可行性和近期疗效。方法选择30例头颈部癌术后或放疗后复发或转移患者。局部浸润麻醉,超声引导下125I粒子植入术。粒子针平行排列,间距1~1.5 cm,原发肿瘤边缘外放1 cm,转移瘤为影像学边界。利用Mick枪后退式植入粒子,粒子间距1 cm。肿瘤周边匹配剂量(matched peripheral dose,MPD)90~160 Gy,每颗粒子活度0.40~0.70 mCi,每个病灶植入3~84颗粒子,中位粒子数24颗。10例粒子剂量低于130 Gy者,术后1周加外放疗,每次2 Gy,总剂量45~50 Gy。术后24 h拍头颈正侧位和胸部X线片,了解粒子移位或游走。结果随访3~33个月,中位数12个月。全组局部控制率为93.3%(28/30),2例因局部复发死亡。1年和2年生存率分别为51.7%和19.4%,中位生存期12个月。无严重皮肤反应。结论放射性125I粒子植入治疗头颈部癌疗效确切,尤其是对那些手术后或放疗复发患者提供了一种安全和微创的治疗手段。
Abstract:
ObjectiveTo investigate the technological feasibility and shortterm efficacy of 125I seeds implantation in head and neck cancer. MethodsThirty patients with head and neck recurrent cancer were treated with 125I seeds interstitial brachytherapy. The opera

参考文献/References:

[1]孙燕,主编.内科肿瘤学.北京:人民卫生出版社,2001.225-239.
[2]殷蔚伯,谷铣之.肿瘤放射治疗学.北京:中国协和医科大学出版社,2002.1108-1111.
[3]Horwitz EM,Frazier AJ,Martinez AA,et al.Excellent functional outcome in patients with squamous cell carcinoma of the base of tongue treated with external irradiation and interstitial iodine 125 boost.Cancer,1996,78(5):948-957.
[4]王俊杰,修典荣,冉维强,等.放射性125I粒子治疗无法手术切除胰腺癌.消化外科杂志,2003,2:339-342.
[5]王俊杰,黄毅,冉维强,等.125I粒子植入治疗前列腺癌临床应用.中华放射医学与防护杂志,2004,2:148-149.
[6]王俊杰,修典荣,冉维强,主编.放射性粒子组织间近距离治疗肿瘤.第2版.北京:北京医科大学出版社,2004.26-45.
[7]Harrison LB.Application of brachytherapy in head and neck cancer.Semi Surg Oncol,1997,13:177-184.
[8]Slanina J,Wannenmacher M,Kuphal K,et al.Interstitial radiotherapy with 198Au seeds in the primary management of carcinoma of the oral tongue: results in Freiburg/Breisgau from January 1964 to July 1980.Int J Radiat Oncol Biol Phys,1982,8(10):1683-1689.
[9]Goffinet DR,Martinez A,Fee WE Jr.I125 vicry suture implants as a surgical adjuvant in cancer of the head and neck.Int J Radiat Oncol Biol Phys,1985,11:399-402.
[10]Park RL,Liberman FZ,Lee DL,et al.Iodine125 seed implantations as an adjuvant to surgery in advanced recurrent squamous cell cancer of the head and neck.Laryngoscope,1991,101:405-410.
[11]Ashamalla H,Rafla S,Zaki B,et al.Radioactive gold grain implants in recurrent and locally advanced headandneck cancers.Brachytherapy,2002,1(3):161-166.

更新日期/Last Update: 2013-11-15