[1]林富禄,岳志健,王来兴,等.质子磁共振波谱在胶质瘤诊断中的应用[J].中国微创外科杂志,2006,06(12):968-970.
　Lin Fulu,Yue Zhijian,Wang Laixing,et al.Use of 1H magnetic resonance spectroscopy in the diagnosis of gliomas[J].Chinese Journal of Minimally Invasive Surgery,2006,06(12):968-970.
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质子磁共振波谱在胶质瘤诊断中的应用()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
06
期数:
2006年12期
页码:
968-970
栏目:
出版日期:
2006-12-30

文章信息/Info

Title:
Use of 1H magnetic resonance spectroscopy in the diagnosis of gliomas
作者:
林富禄; 岳志健; 王来兴; 周晓平
第二军医大学长海医院神经外科,上海,200433
Author(s):
Lin Fulu;  Yue Zhijian;  Wang Laixing;  et al.
Department of Neurosurgery, Second Military Medical University Changhai Hospital, Shanghai 200433, China
关键词:
胶质瘤; 质子磁共振波谱
Keywords:
Glioma; 　1H magnetic resonance spectroscopy
分类号:
R739.41;R445.2
文献标志码:
A
摘要:
目的 探讨质子磁共振波谱(1H magnetic resonance spectroscopy,1H MRS)在胶质瘤诊断及分级中的应用.方法 回顾分析我院2003年3月～2005年9月质子磁共振波谱检查并经病理证实的36例胶质瘤的临床资料,根据胶质瘤恶性程度不同分为A、B 2组,其中A组为低恶性组(包括星形细胞瘤Ⅰ级和Ⅱ级、室管膜瘤、少突胶质细胞瘤等)21例,B组为高恶性组(包括星形细胞瘤Ⅲ级和Ⅳ级、多形性胶质母细胞瘤、间变型室管膜瘤、髓母细胞瘤)15例.观察氮乙酰门冬氨酸(N-acetylaspartate,NAA)、胆碱(choline,Cho)、肌酸(creatine,Cr)、肌醇(Ins)的共振峰及比值.大脑对侧对应正常脑组织的结果作内对照组.结果 2组胶质瘤均表现为异常的1H MRS,与大脑对侧对应正常脑组织相比,A、B 2组表现为NAA/Cr含量显著下降,Cho/Cr含量显著增高(P均＜0.05),Cr总量变化不大,且无规律性(P＞0.05),Ins含量表现为轻度下降(P＞0.05).A组NAA/Cr和NAA/Cho均显著高于B组(t=4.235,P=0.011;t=2.832,P=0.031),A组Cho/Cr显著低于B组(t=-2.323,P=0.042).结论 1H MRS可提高对胶质瘤诊断和分级的准确性.
Abstract:
Objective　To evaluate1H magnetic resonance spectroscopy (1HMRS) in the diagnosis and grading of glioma. M ethods　Clinical data of 36 cases of glioma diagnosed by1H MRS from March 2003 to September 2005 were retrospectively reviewed. According to themalignancy ofglioma, these caseswere divided into two groups: GroupA (21 moderatelymalignant cases, including astrocytoma gradeⅠandⅡ, ependymoma, and oligodendroglioma) and Group B (15 highly malignant cases, including astrocytoma gradeⅢandⅣ, glioblastomamultiforme, anaplastic ependymoma, andmedulloblastoma). Each casewas given a single voxelMRS simultaneously in both the lesion’s region and the contralateral side. The peak values and the ratios ofN-acetylaspartate (NAA), choline (Cho), creatine (Cr), and inositol ( Ins) were recorded.　Results　Compared with the contralateral side,1H MRS exhibited abnormal findings in both groups, including significantly decreased NAA/Cr levels, increased Cho/Cr levels (P< 0·05), invariantand rulelessCr levels (P>0. 05), and slightly decreased Ins (P>0. 05). TheNAA/CrandNAA/Cho in theGroup A were significantly higher than those in theGroup B (t=4.235, P=0.011; t=2.832, P=0. 031), and the Cho/Cr in theGroupA was significantly lower than that in theGroup B (t=-2.323, P=0. 042).　Conclusions　1Hmagnetic resonance spectroscopy can improve the diagnostic accuracy of glioma.

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更新日期/Last Update: 2014-03-03