[1]季晓昕,骆成玉,张键,等.乳腺癌新辅助化疗后腋窝淋巴结的变化[J].中国微创外科杂志,2006,06(4):272-274.
　Ji Xiaoxin,Luo Chengyu,Zhang Jian,et al.Changes of axillary lymph node status in breast cancer after neoadjuvant chemotherapy[J].Chinese Journal of Minimally Invasive Surgery,2006,06(4):272-274.
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乳腺癌新辅助化疗后腋窝淋巴结的变化()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
06
期数:
2006年4期
页码:
272-274
栏目:
出版日期:
2006-04-20

文章信息/Info

Title:
Changes of axillary lymph node status in breast cancer after neoadjuvant chemotherapy
作者:
季晓昕; 骆成玉; 张键; 杨齐; 王国庆; 林华
首都医科大学附属复兴医院普外科,北京,100038
Author(s):
Ji Xiaoxin;  Luo Chengyu;  Zhang Jian;  et al.
Department of General Surgery, Affiliated Fuxing Hospital of Capital University of Medical Sciences, Beijing 10038, China
关键词:
新辅助化疗; 乳腺癌; 腋窝淋巴结
Keywords:
Neoadjuvant chemotherapy; 　Breast cancer; 　Axillary lymph node
分类号:
R737.9
文献标志码:
A
摘要:
目的评价新辅助化疗对乳腺癌腋窝淋巴结的影响.方法45例Ⅱ、Ⅲ期乳腺癌接受新辅助化疗后手术(新辅助化疗联合手术组),根据体检、B超及钼靶像计数腋窝淋巴结总数和阳性、阴性淋巴结数,与未行新辅助化疗直接手术治疗的79例乳腺癌(直接手术组)比较,观察腋窝淋巴结的变化.结果新辅助化疗联合手术组检出腋窝总淋巴结和阳性淋巴结为(16.9±5.9)枚和(2.5±2.2)枚,显著低于直接手术组的(20.8±8.0)枚和(3.9±3.0)枚(t=-2.856,P=0.005;t=2.790,P=0.006),2组阴性淋巴结分别为(14.4±5.4)枚和(16.7±7.0)枚,无统计学差异(t=-1.904,P=0.055).新辅助化疗联合手术组40例随访6～19个月,平均10个月;直接手术组67例随访7～21个月,平均12个月,2组各有4例复发.结论乳腺癌经新辅助化疗后行腋窝淋巴结清扫所检出的淋巴结总数和阳性淋巴结数减少.
Abstract:
Objective　To evaluate effects ofneoadjuvant chemotherapy on axillary lymph node status in patientswith breast cancer.　M ethods　A total of45 patientswith stageⅡorⅢbreastcancer treatedwith neoadjuvantchemotherapy followed by surgery (CombinationGroup) were comparedwith 79 patientswith breastcancer treatedwith initial surgery only (SurgeryGroup) in respectof axillary lymph node status, including the total number of the lymph nodes and the number of positive and negative lymph nodes, according to findings ofphysical examination, B-ultrasonography, andmolybdenum target radiography.　Results　The totalnumberof the lymph nodes and the numberofpositive lymph nodeswere significantly less in the CombinationGroup (16. 9±5. 9 and 2. 5±2·2) than in the SurgeryGroup (20. 8±8. 0 and 3. 9±3. 0) (t=-2.856, P=0.005; t=2.790, P=0. 006), whereas the number of negative lymph nodes were 14. 4±5. 4 and 16. 7±7. 0 in the Combination Group and the Surgery Group, respectively, without statistical significance (t=-1.904, P=0. 055). Four patients were found loco-regional relapse in each group during follow-up checkups for6~19 months (mean, 10 months) in 40 patients in the CombinationGroup and 7~21 months (mean, 12 months) in 67 patients in the SurgeryGroup.　Conclusions　Total and positive axillary lymph nodes retrieved after axillary lymph node dissection decrease in number after neoadjuvant chemotherapy.

参考文献/References:

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更新日期/Last Update: 2014-01-27