[1]傅卫,袁炯,王亮,等.腹腔镜直肠癌前切除对患者机体免疫功能的影响[J].中国微创外科杂志,2005,05(12):1058-1060.
　FuWei,Yuan Jiong,Wang Liang,et al.Effects of laparoscopic anterior resection of rectal carcinoma on immune functions[J].Chinese Journal of Minimally Invasive Surgery,2005,05(12):1058-1060.
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腹腔镜直肠癌前切除对患者机体免疫功能的影响()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年12期
页码:
1058-1060
栏目:
实验研究
出版日期:
2005-12-30

文章信息/Info

Title:
Effects of laparoscopic anterior resection of rectal carcinoma on immune functions
作者:
傅卫; 袁炯; 王亮; 李振荣①; 张同琳
北京大学第三医院普通外科,北京,100083
Author(s):
FuWei;  Yuan Jiong;  Wang Liang;  et al.
Department ofGeneralSurgery, Peking UniversityThirdHospital, Beijing100083, China
关键词:
腹腔镜; 直肠癌; 免疫功能
Keywords:
Laparocopy; 　Rectal carcinoma; 　Immune function
分类号:
R735.3+7
文献标志码:
A
摘要:
目的探讨腹腔镜和开腹直肠癌前切除对患者机体免疫功能的影响.方法2004年4月-2005年6月,我科行开腹和腹腔镜直肠癌前切除38例,腹腔镜组18例,开腹组20例.采用流式细胞仪测定外周血中CD3、CD4、CD8、NK细胞的百分比,采用免疫速率散射比浊法测定免疫球蛋白(IgA、M、G)以及补体C3、C4,以评定患者的免疫功能.结果患者术后24 h、96 h,开腹组和腹腔镜组CD3、CD4、CD8、血清免疫球蛋白及补体C3、C4同术前相比差异均无显著性.NK细胞,腹腔镜组术后24 h、96 h同术前相比差异无显著性,而开腹组明显低于术前.结论与开腹手术相比,腹腔镜下直肠癌前切除对患者NK细胞的影响少.
Abstract:
Objective　To compare effects of laparoscopic versus open anterior resection of rectal carcinoma on immune functions.　M ethods　A total of38 patientswere given either laparoscopic (18 patients) or open (20 patients) anterior resection of rectal carcinoma from April 2004 to June 2005 in this department. The percentages ofT-lymphocytes (CD3, CD4, and CD8) and natural killer cellswere calculated by using the flowcytometry. The levels of immunoglobins ( IgG, IgA, and IgM) and complements (C3and C4) were detected by using the immunonephelometry.　Results　In levels of T-lymphocytes, immunoglobins, and complements, therewere no statistically significantdifferences between open and laparoscopic groups 24 and 96 hours after operation. In levels ofnatural killer cells, no differenceswere observed in laparoscopic group before and after operation (24 and 96 postoperative hours) while a significant decrease were found in open group after operation.　Conclusions　As compared with open surgery, laparoscopic anterior resection of rectal carcinoma has less influence on natural killer cells.

参考文献/References:

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[2]Sallya P, Kirman I, Whelan RL. Immunological advantages of advanced laparoscopy. Surg Clin N Am,2005,85( 1 ) :1 - 18.
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[6]胡建昆,周总光,陈志新,等.腹腔镜和开腹直肠癌全系膜切除对免疫功能的影响.中华普通外科杂志,2004,19(2):88-90.
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备注/Memo

备注/Memo:
①检验科
更新日期/Last Update: 2014-04-29