[1]耿力,宋雪玲,郭艳利.宫颈环形电切术在宫颈上皮内瘤样病变Ⅱ级处理中的应用[J].中国微创外科杂志,2005,05(12):1040-1041.
　GengLi,SongXueling,Guo Yanli..Management of cervical intraepithelial neoplasia grade Ⅱ by loop electrosurgical excision procedure[J].Chinese Journal of Minimally Invasive Surgery,2005,05(12):1040-1041.
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宫颈环形电切术在宫颈上皮内瘤样病变Ⅱ级处理中的应用()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年12期
页码:
1040-1041
栏目:
出版日期:
2005-12-30

文章信息/Info

Title:
Management of cervical intraepithelial neoplasia grade Ⅱ by loop electrosurgical excision procedure
作者:
耿力; 宋雪玲; 郭艳利
北京大学第三医院妇产科,北京,100083
Author(s):
GengLi;  SongXueling;  Guo Yanli.
Department ofObstetrics& Gynecology, Peking UniversityThirdHospital, Bejing100083, China
关键词:
环形电切术; 宫颈上皮内瘤样病变
Keywords:
Loop electrosurgical excision procedure; 　Cervical intraepithelial neoplasia
分类号:
R737.33
文献标志码:
A
摘要:
目的探讨环形电切术(loop electrosurgical excision procedure,LEEP)治疗宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)Ⅱ级的效果.方法28例阴道镜下宫颈活检病理学诊断为CINⅡ级,其中高危型人乳头瘤病毒(human papillomavirus,HPV)DNA阳性率96.4%(27/28).表面麻醉后环形电极切割宫颈组织,再用方形或小环形电极切除中央部分组织,包括部分颈管,术后随访.结果术中出血0～20 ml,手术时间5～10 min,术后3例阴道出血相当于月经量,无其他合并症.手术标本无明显炭化,15例(53.6%)CIN病灶消失,病变级别降低为CIN Ⅰ级5例,级别不变5例,级别增加至CINⅢ级3例.28例随访6～24个月,平均16个月.28例治愈,未发现CIN病变残留和复发,高危型HPV DNA转阴23例.结论LEEP是治疗CINⅡ级安全有效的方法,其优点是微创,手术操作简便,诊断与治疗能同时进行,无须住院.
Abstract:
Objective　To evaluate the effectiveness of loop electrosurgical excision procedure (LEEP) for themanagementof cervical intraepithelial neoplasia (CIN) gradeⅡ.　M ethods　A total of 28 patients were pathologically diagnosed as having CIN gradeⅡby colposcopic cervical biopsy. High-risk human papillomavirus (HPV) DNA testing showed positive results in 96. 4% of the patients (27/28). The procedurewas conducted under surface anesthesia. A loop electrode was used to cut through the cervical tissues, and then a square-shaped electrode or a small-sized loop electrode was utilized to complete the resection of lesions, including parts of the cervical cana.l All the patientswere followed postoperatively.　Results　The intraoperative blood losswas 0~ 20 m,l and the operation timewas5~10min. Outof the 28 patients, postoperative abnormalvaginalbleedingwas found in 3 patients. No other complications occurred. The resected tissues showed no obvious charring changes. The lesions ofCIN completely disappeared in 15 patients (53. 6% ), subsided to gradeⅠin 5 patients, remained in gradeⅡin 5 patients, and progressed to gradeⅢin 3 patients. Follow-up examinations in the 28 patients for6~24 months (mean, 16 months) found no residual lesions or recurrence. The high-riskHPV DNA findings turned negative in 23 patients.　Conclusions　LEEP is a safe and effective procedure for the treatment ofCIN gradeⅡ, with advantages of little invasion, simplicity of performance, and no need ofhospitalization.

参考文献/References:

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更新日期/Last Update: 2014-04-29