[1]张元生,尹鲜花,李蓉,等.三维适形放疗联合化疗综合治疗肝癌87例近期疗效分析[J].中国微创外科杂志,2005,05(2):116-118.
　Zhang Yuansheng,Yin Xianhua,Li Rong,et al.Three-dimensional conformal radiotherapy with chemotherapy for hepatic carcinoma: Analysis of short-term effects in 87 cases[J].Chinese Journal of Minimally Invasive Surgery,2005,05(2):116-118.
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三维适形放疗联合化疗综合治疗肝癌87例近期疗效分析()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年2期
页码:
116-118
栏目:
出版日期:
2005-02-28

文章信息/Info

Title:
Three-dimensional conformal radiotherapy with chemotherapy for hepatic carcinoma: Analysis of short-term effects in 87 cases
作者:
张元生; 尹鲜花; 李蓉; 焦丽平
山西医科大学第三医院肿瘤治疗中心,太原,030053
Author(s):
Zhang Yuansheng;  Yin Xianhua;  Li Rong;  et al.
Tumor Treatment Center, Affiliated Third Hospital of Shanxi Medical University, Taiyuan 030053, China
关键词:
肝癌;  化疗;  三维适形放疗;  肝动脉介入化疗栓塞术
Keywords:
Hepatic carcinoma; 　Chemotherapy; 　Three-dimensional conformal radiotherapy; 　Transcatheter arterial chemoembolization
分类号:
R735.705.3;R815
文献标志码:
A
摘要:
目的探讨三维适形放疗(three-dimensional conformal radiotherapy, 3D-CRT)联合肝动脉介入化疗栓塞术(transcatheter arterial chemoembolization, TACE)治疗原发性肝癌及3D-CRT联合化疗治疗转移性肝癌的近期疗效. 方法对52例原发性肝癌先采用TACE治疗1次,休息2周后进行3D-CRT, 肿瘤剂量2～3 Gy/次,每天1次或隔日1次,3～5次/周,剂量范围42.2～60.0 Gy,平均52.2 Gy,放疗结束后再进行2次TACE.对35例转移性肝癌先化疗1个周期,然后行3D-CRT,放疗结束后再巩固化疗2个周期,进行疗效评价,有效者继续化疗3个周期,共6个周期. 结果完全缓解(CR)23.0%(20/87),部分缓解(PR)39.1%(34/87),病情稳定(SD)34.5%(30/87),进展(PD)3.4%(3/87).有效(RR)62.1%(54/87). 结论 3D-CRT联合TACE治疗原发性肝癌和3D-CRT联合化疗治疗转移性肝癌能够提高局部控制率,近期疗效好.
Abstract:
Objective　To evaluate the short- term effects of three-dimensional conformal radiotherapy (3D -CRT) associated with transcatheter arterial chemoembolization (TACE) in the treatment of primary hepatic carcinoma and 3D -CRT associated with chemotherapy in the treatment of metastatic hepatic carcinoma.　M ethods　In 52 patients with primary hepatic carcinoma, first of all a single TACE was conducted. Then after an interval of2 weeks, the conformal radiotherapywas given, with a radiation dose of2~3 Gy every fraction, once daily oronce every otherday and 3~5 fractions everyweek. The total radiation dose to the targetwas 42. 2~60. 0 Gy (mean, 52. 2 Gy). Afterwards, 2 additionalTACEswere given after the radiotherapy. In 35 patients withmetastatic hepatic carcinoma, chemotherapywas carried out for 1 treatment course firstly. Then 3D-CRT was employed. After the radiotherapy, another2 courses of consolidating chemotherapywere administrated. The patient continuedwith the chemotherapy for additional3 treatment courses (a total of 6 courses) if efficacy evaluation showed the patient had responded to the chemotherapy.　 Results　The response outcomeswere: complete remission (CR) 23·0% (20/87), partial remission (PR) 39·1% (34/87), stable disease (SD) 34·5% (30/87) and progressive disease (PD) 3·4% (3/87), the response rate (RR) being 62·1% (54/87).　 Conclusions　3D-CRTwith TACE for primary hepatic carcinoma and 3D-CRTwith chemotherapy formetastatic hepatic carcinoma offers high local control rates and good short-term effects.

参考文献/References:

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更新日期/Last Update: 2014-03-11