[1]梅方雄①,李荣,叶永红,等.集束电极射频毁损术治疗不能切除的大肝癌[J].中国微创外科杂志,2005,05(2):111-112.
　Mei Fangxiong,LiRong*,Ye Yonghong*,et al.Treatment of unresectable large liver cancer by radiofrequency ablation with clustered electrodes[J].Chinese Journal of Minimally Invasive Surgery,2005,05(2):111-112.
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集束电极射频毁损术治疗不能切除的大肝癌()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年2期
页码:
111-112
栏目:
出版日期:
2005-02-28

文章信息/Info

Title:
Treatment of unresectable large liver cancer by radiofrequency ablation with clustered electrodes
作者:
梅方雄①; 李荣; 叶永红; 高焱明
广东医学院附属湛江中心医院肝胆外科,湛江,524037
Author(s):
Mei Fangxiong;  LiRong*; Ye Yonghong*;  et al.
*Department ofHepatobiliary Surgery, Zhanjiang CentralHospital ofGuangdongMedical College, Zhanjiang 524037, China
关键词:
肝癌;  射频治疗
Keywords:
Liver cancer; 　Radiofrequency ablation
分类号:
R735.705.4
文献标志码:
A
摘要:
目的探讨集束电极射频毁损术治疗不能切除的原发性大肝癌的临床价值.方法 B超引导经皮穿刺38例,术中穿刺5例.治疗后复查发现肿瘤残存或复发者可重复治疗. 结果 43例(肿瘤直径平均7.3 cm),行射频毁损术治疗62次,平均每次6点.术前AFP>400 μg/L者56.3%(18/32)治疗后降至正常.术后CT检查76.7%(33/43)肿瘤完全毁损.常见的并发症有发热、疼痛、肝功能受损,无严重并发症或与操作相关的死亡.1年存活79.3%(23/29). 结论集束电极射频毁损术治疗不能切除的大肝癌,可使大范围的肿瘤发生热坏死,是一种安全有效的治疗方法,为无法切除的大肝癌开辟了一条新的治疗途径.
Abstract:
Objective　To evaluate the clinical significance of radiofrequency ablation (RFA) with clustered electrodes in the treatment of unresectable large primary liver cancer.　M ethods　Under the guidance of ultrasonography, Percutaneous and intraoperative RFA was performed in 38 patients and 5 patients, respectively. Additional ablation could be conducted if residual tumor or recurrencewas found after the primary treatment.　Results　A total of 62 times ofRFA, with a mean of 6 foci every treatment, were completed in the 43 patients, in whom the mean diameter of tumorwas 7·3 cm. AFP levels had decreased to normal in 18/32 patients (56·3% ) whose preoperativeAFP levelswere above 400μg/L. Postoperative CT examinations indicated that the tumorwas completely ablated in 33/43 patients (76·7% ). Frequent complications included fever, local pain, and liver impairment. No severe complications or treatment-related deathswere seen. The 1-year survival rate was 79·3% (23/29).　Conclusions　RFA with clustered electrodes in the treatmentofunresectable large liver cancer can produce extensive coagulation necrosis of tumor, being a safe and effective therapeuticmethod. It is breaking fresh ground in themanagement ofunresectable large liver cancer.

参考文献/References:

[1]谢晓燕,吕明德,殷晓煜,等. 超声引导经皮射频消融治疗肝癌的研究. 中华外科杂志,2003,41:23-26.
[2]Curley SA, Izzo F, Delrio P, et al. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients.Ann Surg,1999,230:1-8.
[3]Poon RT, Ng KK, Lam CM, et al. Effectiveness of radiofrequency ablation for hepatocellular carcinomas larger than 3 cm in diameter. Arch Surg,2004,139:281-287.
[4]马庆久,王青,鲁建国,等. 集束电极射频消融治疗肝癌术后并发症的原因分析及其防治.中华外科杂志,2003,41:805-808.

备注/Memo

备注/Memo:
①（佛山市三水妇儿医院外科,佛山,528100）
更新日期/Last Update: 2014-03-11