[1]陈焕伟,甄作均,崔伟珍①,等.经皮射频消融或联合肝动脉、门静脉栓塞化疗治疗原发性及复发性小肝癌[J].中国微创外科杂志,2005,05(2):108-110.
　Chen Huanwei*,Zhen Zuojun*,Cui Weizhen,et al.Treatment of primary and recurrent small hepatocellular carcinoma with percutaneous radiofrequency ablation with or without hepatic artery and portal vein chemoembolization[J].Chinese Journal of Minimally Invasive Surgery,2005,05(2):108-110.
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经皮射频消融或联合肝动脉、门静脉栓塞化疗治疗原发性及复发性小肝癌()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年2期
页码:
108-110
栏目:
出版日期:
2005-02-28

文章信息/Info

Title:
Treatment of primary and recurrent small hepatocellular carcinoma with percutaneous radiofrequency ablation with or without hepatic artery and portal vein chemoembolization
作者:
陈焕伟; 甄作均; 崔伟珍①; 王军华; 苏树英; 许卓明; 廖珊②
佛山市第一人民医院肝胆外科,佛山,528000
Author(s):
Chen Huanwei*;  Zhen Zuojun*;  Cui Weizhen;  et al.*
*Department of Hepatobiliary Surgery, Foshan First People’s Hospital, Foshan 528000, China
关键词:
肝肿瘤;  治疗;  射频;  微创
Keywords:
Liver neoplasm; 　Treatment; 　Radiofrequency; 　Minimal invasion
分类号:
R735.7
文献标志码:
A
摘要:
目的探讨经皮射频消融或联合肝动脉、门静脉栓塞化疗治疗原发性及复发性小肝癌的价值. 方法 2001年9月～2004年9月,采用经皮射频消融(percutaneous radiofrequency ablation,PRFA)方法治疗原发性小肝癌(肿瘤直径≤5 cm)11例和复发性小肝癌(肿瘤直径≤3 cm)13例,其中4例原发性肝癌和8例复发性肝癌结合肝动脉及门静脉栓塞化疗.结果在11例原发性小肝癌中,6例肿瘤直径≤3 cm者,MRI或CT提示瘤灶完全凝固性坏死;5例肿瘤直径3～5 cm者,MRI或CT提示4例肿瘤完全凝固性坏死.1、1.5、2年累积生存率分别为100%、85.71%、68.57%.在13例复发性小肝癌中,单发组(7例)MRI或CT提示瘤灶完全凝固性坏死;多发组(6例)共15个瘤灶,MRI或CT提示12个瘤灶完全凝固性坏死.1、1.5、2年累积生存率分别为88.89%、77.78%、64.81%. 结论 PRFA为原发性及复发性小肝癌的治疗提供了一种新的手段,对肿瘤直径超过3 cm以及复发性肝癌结合肝动脉、门静脉栓塞化疗有助于提高肿瘤坏死率,减少复发率,有效提高生存率.
Abstract:
Objective　To explore the value of percutaneous radiofrequency ablation (PRFA) with orwithout transcatheter hepatic artery and portal vein chemoembolization in the treatment ofprimary and recurrent smallhepatocellular carcinoma.　M ethods 　Ultrasound-guided percutaneous radiofrequency ablation was adopted in the treatment of 11 cases of primary small hepatocellular carcinoma (≤5 cm) and 13 cases of recurrent small hepatocellular carcinoma (≤3 cm) from September 2001 to September 2004. Among them, a combined use of transcatheter hepatic artery and portal vein chemoembolization was conducted in 4 cases of primary hepatocellular carcinoma and 8 cases of recurrent hepatocellular carcinoma.　Results　Out of the 11 cases of primary small hepatocellular carcinoma, CT orMRI results showed a complete coagulation necrosis of lesion in all6 cases in which tumorswere not more than 3 cm in diameter and in 4 out of5 cases in which tumorswere between 3 cm and 5 cm in diameter, the 1-, 1. 5- and 2-year cumulative survival rates being 100%, 85·71% and 68·57%, respectively. Out of the 13 cases of recurrent small hepatocellular carcinoma, CT orMRI results showed a complete coagulation necrosis in all7 lesions in cases of solitary tumor and in 12 out of15 lesions in 6 cases ofmultiple tumors, the 1-, 1. 5- and 2-year cumulative survival rates being 88. 89%, 77·78% and 64·81%, respectively.　Conclusions　Percutaneous radiofrequency ablation provides a new alternative for the treatment of primary and recurrent small hepatocellular carcinoma. For patients with tumormore than 3 cm in diameter or with recurrent hepatocellular carcinoma, a combined use of transcatheterhepatic artery and portal vein chemoembolization conduces to a high tumornecrosis rate, a decrease of recurrence and an elevation of survival rate.

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备注/Memo

备注/Memo:
基金项目：本课题为广东省医学科研基金项目(A2002696);广东省科技发展项目(2004-64)，①超声科，② 统计室
更新日期/Last Update: 2014-03-11