[1]陈敏山,张耀军,李锦清,等.射频消融或联合经皮瘤内无水乙醇注射治疗小肝癌181例疗效分析[J].中国微创外科杂志,2005,05(2):105-107.
　Chen Minshan,Zhang Yaojun,Li Jinqing,et al.Radiofrequency ablation with or without percutaneous ethanol injection in the treatment of 181 cases of small hepatocellular carcinoma[J].Chinese Journal of Minimally Invasive Surgery,2005,05(2):105-107.
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射频消融或联合经皮瘤内无水乙醇注射治疗小肝癌181例疗效分析()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
05
期数:
2005年2期
页码:
105-107
栏目:
出版日期:
2005-02-28

文章信息/Info

Title:
Radiofrequency ablation with or without percutaneous ethanol injection in the treatment of 181 cases of small hepatocellular carcinoma
作者:
陈敏山; 张耀军; 李锦清; 梁惠宏; 张亚奇; 郑云
中山大学肿瘤防治中心肝胆科,广州,510060
Author(s):
Chen Minshan;  Zhang Yaojun;  Li Jinqing;  et al.
Department of Hepatobiliary Diseases, Prevention & Treatment Centerfor Tumors of Sun Yat-sen University, Guangzhou 510060, China
关键词:
肝肿瘤;  射频消融;  无水乙醇注射;  疗效
Keywords:
Hepatocellular carcinoma; 　Radiofrequency ablation; 　Ethanol injection; 　Effectiveness
分类号:
R735.705.4
文献标志码:
A
摘要:
目的总结经皮射频消融(radiofrequency ablation, RFA)治疗小肝癌的疗效. 方法应用RFA治疗小肝癌(≤5 cm)181例,其中RFA治疗128例,经皮瘤内无水乙醇注射(percutaneous ethanol injection, PEI)-RFA治疗53例. 结果全部病例随访1～46月(中位时间17月).1,2,3年生存率分别为89.47%,74.42%,49.88%.单发病灶直径＜3.0 cm组,1,2,3年生存率分别为94.63%,83.69%,70.47%;单发直径3.0～5.0 cm组为89.01%,69.39%,50.11%;多发病灶直径之和≤5.0 cm 组为78.28%,62.82%,0(P=0.041 9).RFA,PEI-RFA组1,2,3年生存率分别为88.23%,73.58%,45.97%和92.73%,76.83%,76.83%(P=0.316 8). 结论 RFA是一种安全有效的治疗手段,其结果受病灶大小和肿瘤数目的影响,与PEI联合应用或许可以提高疗效.
Abstract:
Objective　To summarize the effectiveness of radiofrequency ablation (RFA) with orwithoutpercutaneous ethanol injection (PEI) in the treatment of small hepatocellular carcinoma.　M ethods　A series of 181 patients with small hepatocellular carcinoma (≤5 cm) were treated by eitherRFA alone (128 patients) orRFA-PEI (53 patients).　Results　All the patientswere followed up for1~46months (median, 17months). The 1-, 2- and 3-year survival rateswere 89·47%, 74. 42% and 49·88%, respectively. When the patientswere separated into 3 groups according to the size of tumors, the 1-, 2- and 3-year survival rates in patientswith solitary tumor <3·0 cm in diameterwere 94·63%, 83·69% and 70·47%, in patientswith solitary tumor3·0~5·0 cm in diameterwere 89·01%, 69·39% and 50·11%, and in patients with multiple lesions≤5·0 cm in the sum of diameters, 78·28%, 62·82% and 0, respectively (P=0·041 9). The 1-, 2- and 3-year survival rates in RFA patients and RFA-PEI patientswere 88·23%, 73·58% and 45·97%, and 92·73%, 76·83% and 76·83%, respectively (P=0·316 8).　Conclusions　 RFA is an effective and safe therapeutic option but its effectiveness is influenced by the size and number of tumors. Combined use of RFA and PEImay ormay not enhance the effectiveness.

参考文献/References:

[1]Buscarini L,Rossi S.Technology for radiofrequency thermal ablation of liver tumors. Semin Laparosc Surg, 1997, 4:96-101.
[2]Rossi S, Fornari F, Pathies C, et al. Thermal lesions induced by 480 kHz localized current field in guinea pig and pig liver. Tumori, 1990,76(1): 54-57.
[3]Buscarini L, Buscarini E, Di-Stasi M, et al. Percutaneous radiofrequency ablation of small hepatocellular carcinoma: long-term results. Eur Radiol, 2001, 11(6): 914-921.
[4]Xin-Da Zhou, Zhao-You Tang, Bing-Hui Yang, et al. Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma. Cancer, 2001, 91(8):1479-1486.
[5]Livraghi T, Lazzaroni S, Meloni F. Radiofrequency ablation of hepatocellular carcinoma. Eur J Ultrasund, 2001, 13:159-166.
[6]Buscarini L,Buscarini E,Di Stasi M,et al.Percutaneous radiofrequency thermal ablation combine with transcatheter arterial embolization in the treatment of large hepatocellular carcinoma. Ultraschall Med, 1999, 20(2):47-53.
[7]Giorgio A, Tarantino L, de-Stefano G, et al. Percutaneous sonographically guided saline-enhanced radiofrequency ablation of hepatocellular carcinoma. AJR Am J Roentgenol, 2003, 181(2): 479-484.
[8]陈敏山,郑云,张亚奇,等.经皮射频联合瘤内无水乙醇注射治疗肝癌.癌症,2001,20(7):759-761.
[9]Kurokohchi K, Watanabe S, Masaki T,et al. Combined use of percutaneous ethanol injection and radiofrequency ablation for the effective treatment of hepatocelluar carcinoma. Int J Oncol, 2002, 21(4): 841-846.
[10]Watanabe S, Kurokohchi K, Masaki T, et al. Enlargement of thermal ablation zone by combined of ethanol injection and radiofrequency ablation in excised bovine liver. Int J Oncol, 2004, 24(1): 279-284.

备注/Memo

备注/Memo:
基金项目：广东省科委社会攻关基金(编号:2002 C31107);广东省医学科研基金(编号:A2002225);广州市科委科技攻关基金(编号:2002 Z3-J20182)
更新日期/Last Update: 2014-03-11