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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:

02

期数:

2002年4期

页码:

240-248

栏目:

新技术新方法

出版日期:

2002-08-31

文章信息/Info

Title:

Xenotransloantation of APA microencapsulated neonatal swine islet cells by laparoscopic procedure

作者:

章乐虹　 陈德　 胡以则　 焦群　

广州医学院第二附属医院普外科,广州,510260

Author(s):

ZhangLehong;  ChenDe; Hu Yize; et al.

Department ofSurgery,SecondAffiliatedHospital,GuangzhouMedical College,Guangzhou510260, China

关键词:

腹腔镜 胰岛 异种移植 胰岛素依赖型糖尿病

Keywords:

Laparoscope　Islets of langerhans　Xenotransplantation

分类号:

R617

文献标志码:

A

摘要:

目的探讨腹腔镜技术应用于海藻酸钠-聚赖氨酸-海藻酸钠(APA)微囊包裹猪胰岛小网膜腔内异种移植术的可行性. 方法采用腹腔镜技术对5例6人次Ⅰ型糖尿病患者进行了APA微囊新生猪胰岛小网膜腔内异种移植治疗,观察患者移植前后空腹血糖、C肽和胰岛素用量变化. 结果全部病例均未出现手术并发症.术后受体C肽较术前升高3-23倍,胰岛素用量减少,基中1例完全停用胰岛素,成为胰岛素不依赖者达31个月. 结论腹腔镜技术用于临床微囊化新生猪胰岛小网膜腔移植术治疗Ⅰ型糖尿病安全可行.

Abstract:

Objective　To investigate the feasibility and security of omentumminus cavity xenotransloantation of al- ginic-polylysine-alginic(APA) microencapsulated neonatal swine islet cells by laparoscopic procedure.　Methods　5 patients with IDDM received the xenotransloantation of APAmicroencapsulated neonatal pig islets in omentum minus cavity by laparoscopic procedure.The patients’general conditions,the change in fast blood glucose level,serum C-peptide and the dose of insulin used were observed before and after the xenotransplantation.　Results　No complications occurred dur- ing operation and after operation.The levels of serum C-peptide increased by 3 to 23 times respectively and the post-op- erative dose of insulin needed decreased obviously.Insulin independencywas achieved in one recipient for up to 31 months. 　Conclusions　Omentum minus cavity xenotransplantation of APA microencapsulated neonatal pig islets for the treatment of IDDM patients by laparoscopic technique is safe and practicable.

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更新日期/Last Update: 2014-07-31