[1]孙颖　 傅贤波①　 周勇　 杨展澜　 杨丽敏　 张利　 周孝思①　 徐怡庄　 凌晓峰①　 沈韬①　 翁诗甫　 吴瑾光.傅立叶变换红外光谱(FT-IR)用于血糖无损检测的研究[J].中国微创外科杂志,2001,01(3):159-161.
　Sun Ying,FuXianbo,Zhou Yong,et al.Study A on noniuvasive measurement of blood glucose with FT - IR ATR technique.[J].Chinese Journal of Minimally Invasive Surgery,2001,01(3):159-161.
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傅立叶变换红外光谱(FT-IR)用于血糖无损检测的研究()
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《中国微创外科杂志》[ISSN:1009-6604/CN:11-4526/R]

卷:
01
期数:
2001年3期
页码:
159-161
栏目:
基础研究
出版日期:
2001-03-31

文章信息/Info

Title:
Study A on noniuvasive measurement of blood glucose with FT - IR ATR technique.
作者:
孙颖　 傅贤波①　 周勇　 杨展澜　 杨丽敏　 张利　 周孝思①　 徐怡庄　 凌晓峰①　 沈韬①　 翁诗甫　 吴瑾光
北京大学化学与分子工程学院北京 100871
Author(s):
Sun Ying;  FuXianbo;  Zhou Yong;  et al.
College ofChemistry andMolecular Engineering, Peking University, Beijing100871, China
关键词:
血糖 糖尿病 FT-IR光谱 FT-IR ATR技术
Keywords:
Blood glucose　　Diabetes　　FT-IR sepectroscopy　　FT-IR ATR technique
分类号:
R587
文献标志码:
A
摘要:
目的血糖无损检测的可行性研究.方法傅立叶变换红外光谱测受试者中指的红外光谱,将1123cm-1附近的葡萄糖特征峰的相对强度与快速血糖仪所测血糖值进行比较.结果1123cm-1附近的特征峰相对强度的变化与血糖值的变化基本同步,该峰的相对强度与血糖值明显相关(R=0.83485,SD=0.13566,P＜0.0001),峰的相对强度可以反映人体血糖值的变化,的确能作为人血糖值的一个数量指标.结论FT-IRATR法进行人体血糖的无创性测定和监测是可行的.
Abstract:
Objective　To study a noninvasive determination of blood glucose concentration in human body. 　Methods　UsingFT-IRAIRtechnique, the relative intensity of~1123cm-1bandswas comparedwiththe determi- nating results of blood glucose with a instant blood glucose instrument.　Results　The relative intensity change of ~ 1123cm-1bands in mid-infrared spectra of middle finger, was in accordance with the variation of blood glucose con- centration in human body, and its relative intensity was significantly related to the blood glucose concentration in hu- man body.(R=0.83485. SD=0.13566.P<0.0001)　Conclusions　This method provides a way to develop a noninvasive and convenient measurement of blood glucose for clinical diagnoses.

参考文献/References:

［1］G uilbault G G, Palleschi G. Non - invasive biosensors in clinical analysis. Biosensors & Bioelectronics, 1995, 10:379- 392.
［2］Heise H M, Marbach R, Koschinsky Th, et al. Multi - component assay for blood subatrates in human plasma by mid - infrared spectroscopy and its evaluation for clinical analysis. Appl Spectrosc, 1994, 18:439 -447.
［3］Svedman P, Svedman C. Skin mini - erosion sampling technique: feasi- bility study with regard to serial glucose measurement. Pharmaceutical Research, 1998, 15:883-888.
［4］Gough DA, Armour JC. Development of the implantable glucoseaensor. What are the prospects and why ia it taking so long? Diabetes, 1995, 44:1005- 1009.
［5］Beard R B, Hung B N, Schmukler R. Biocompatibility considerations at stimulating electrode interfaces. Ann Biomed eng, 1992:20:395 -410.
［6］Boulnoia J L. Lasers Med Science, 1986, 1:47 - 63.
［7］Heinemann L and Schmeleisen- Redeker G. On behalf of the Non - in-vasive task force (NTTF). Non invaaive continuoua gluc~e monitoring in Type I diabetic patients with opttcal glucose aensors. Diabetologia, 1998,41:848 - 854.
［8］Heise H M. Non - invasive monitoring of metabolites using near infrared spectroscopy: state of the art. Horm Metab Res 1996, 28:527 - 534.
［9］Burmeister J J, Arnold M A. Evaluation of measurement sites for noninvasive blood glucose sensing with near- infrared transmission spectroaco py. Clinical Chemistry, 1999, 45:1621 - 1627.
［10］Hazen K H, Arnold M A, Small G W. Measurement of glucose and other analytes in undiluted human serum with near- infrared transmission spectroscopy. Analytica Chimica Acta, 1998, 371:255- 267.
［11］HeiseHM, Marbach R, KoschinskyTh. Non-invasiveblood glucosese sensors based on near-infrared spectroscopy. Artificial Organs, 1994, 18:439-447.
［12］Heise H M. Medical applications of infrared spectroscopy. MikrochimActa. 1997, [Suppl.]14:67-77
［13］沈韬,彭卿,翁诗甫等.傅立叶变换中红外光谱法用于非损伤性血糖测定的研究.光谱学与光谱分析,1996,16;39-42.
［14］T. Shen, Xiaosi Zhou, .Jinguang Wu, et al. Non- invasive measurement of blood glucose using mid - IR fiber Optic spectroscopy. The Pittsburgh Conference97, Atalanta, Georgia. 1997, Abstract 1009.［1］G uilbault G G, Palleschi G. Non - invasive biosensors in clinical analysis. Biosensors & Bioelectronics, 1995, 10:379- 392. ［2］Heise H M, Marbach R, Koschinsky Th, et al. Multi - component assay for blood subatrates in human plasma by mid - infrared spectroscopy and its evaluation for clinical analysis. Appl Spectrosc, 1994, 18:439 -447. ［3］Svedman P, Svedman C. Skin mini - erosion sampling technique: feasi- bility study with regard to serial glucose measurement. Pharmaceutical Research, 1998, 15:883-888. ［4］Gough DA, Armour JC. Development of the implantable glucoseaensor. What are the prospects and why ia it taking so long? Diabetes, 1995, 44:1005- 1009. ［5］Beard R B, Hung B N, Schmukler R. Biocompatibility considerations at stimulating electrode interfaces. Ann Biomed eng, 1992:20:395 -410. ［6］Boulnoia J L. Lasers Med Science, 1986, 1:47 - 63. ［7］Heinemann L and Schmeleisen- Redeker G. On behalf of the Non - in-vasive task force (NTTF). Non invaaive continuoua gluc~e monitoring in Type I diabetic patients with opttcal glucose aensors. Diabetologia, 1998,41:848 - 854. ［8］Heise H M. Non - invasive monitoring of metabolites using near infrared spectroscopy: state of the art. Horm Metab Res 1996, 28:527 - 534. ［9］Burmeister J J, Arnold M A. Evaluation of measurement sites for noninvasive blood glucose sensing with near- infrared transmission spectroaco py. Clinical Chemistry, 1999, 45:1621 - 1627. ［10］Hazen K H, Arnold M A, Small G W. Measurement of glucose and other analytes in undiluted human serum with near- infrared transmission spectroscopy. Analytica Chimica Acta, 1998, 371:255- 267. ［11］HeiseHM, Marbach R, KoschinskyTh. Non-invasiveblood glucosese sensors based on near-infrared spectroscopy. Artificial Organs, 1994, 18:439-447. ［12］Heise H M. Medical applications of infrared spectroscopy. MikrochimActa. 1997, [Suppl.]14:67-77 ［13］沈韬,彭卿,翁诗甫等.傅立叶变换中红外光谱法用于非损伤性血糖测定的研究.光谱学与光谱分析,1996,16;39-42. ［14］T. Shen, Xiaosi Zhou, .Jinguang Wu, et al. Non- invasive measurement of blood glucose using mid - IR fiber Optic spectroscopy. The Pittsburgh Conference97, Atalanta, Georgia. 1997, Abstract 1009.

备注/Memo

备注/Memo:
基金项目：本课题由国家自然科学基金(39730160)及国家重点基础研究发展规划项目(G1998061311)共同资助.①（北京大学第三医院北京 100083）
更新日期/Last Update: 2014-08-22